SUMO1 - small ubiquitin like modifier 1 Gene

Homo sapiens

Also known as DAP1; GMP1; PIC1; SMT3; UBL1; OFC10; SENP2; SMT3C; SMT3H3

Gene ID: 7341 | Gene type: protein coding

About SUMO1

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:202,206,171-202,238,597 (from NCBI)

This gene has 10 transcripts (splice variants), 183 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 51.9), adrenal (RPKM 51.8) and 25 other tissues.

Summary

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, Apoptosis, and protein stability. It is not active until the last four Amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

SUMO1 Products(6)

mRNA	Protein	Name
NM_001005781.2	NP_001005781.1	small ubiquitin-related modifier 1 isoform a precursor
NM_001005782.2	NP_001005782.1	small ubiquitin-related modifier 1 isoform b
NM_001371392.1	NP_001358321.1	small ubiquitin-related modifier 1 isoform d
NM_001371393.1	NP_001358322.1	small ubiquitin-related modifier 1 isoform e
NM_001371394.1	NP_001358323.1	small ubiquitin-related modifier 1 isoform c
NM_003352.8	NP_003343.1	small ubiquitin-related modifier 1 isoform a precursor

SUMO1 Protein Structure

Rad60-SLD

0
101 a.a.

Protein Preferred Names

Protein Names

small ubiquitin-related modifier 1

GAP modifying protein 1

Recombinant SUMO1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70997	SUMO1 Protein, Human (His)	AAH66306 (M1-V101)	≥95%

Related Diseases

Diseases

Alias

Orofacial Cleft 10

OFC10	Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 10
Nonsyndromic Cleft Lip With Or Without Cleft Palate 10	Non-Syndromic Orofacial Cleft 10
Non-Syndromic Cleft Lip/Palate 10	Non-Syndromic Cleft Lip With Or Without Cleft Palate 10
Orofacial Cleft, Type 10

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Cleft Lip

Cheiloschisis	Labium Leporinum
Cleft Lip, Unilateral, Complete	Complete Unilateral Cleft Lip
Hare Lip	Congenital Fissure Of Lip
Isolated Cleft Lip	Cleft Lip Without Cleft Palate
Cleft Lip Without Cleft Palate, Unilateral	Isolated Cleft Lip, Unilateral
Cleft Lip Without Cleft Palate, Bilateral	Isolated Cleft Lip, Bilateral

Orofacial Cleft

Cleft, Orofacial

Orofacial Cleft 4

OFC4	Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 4
Nonsyndromic Cleft Lip With Or Without Cleft Palate 4

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Unilateral Focal Polymicrogyria

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108702	ML-792	Inhibitor	99.90%	Unkown
HY-139662	HB007	Inhibitor	99.20%	Unkown
HY-RS14025	SUMO1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SUMO1	VGNC	VGNC:35473
Mus musculus	SUMO1	MGD	MGI:1197010
Rattus norvegicus	SUMO1	RGD	RGD:1306919
Macaca mulatta	SUMO1	VGNC	VGNC:99409
Others	SUMO1	NCBI

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