TDG - thymine DNA glycosylase Gene

Homo sapiens

Also known as hTDG

Gene ID: 6996 | Gene type: protein coding

About TDG

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:103,965,872-103,988,874 (from NCBI)

This gene has 10 transcripts (splice variants) and 284 orthologues. Ubiquitous expression in lymph node (RPKM 10.7), appendix (RPKM 8.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this Enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This Enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]

TDG Products(2)

mRNA	Protein	Name
NM_001363612.2	NP_001350541.1	G/T mismatch-specific thymine DNA glycosylase isoform 2
NM_003211.6	NP_003202.3	G/T mismatch-specific thymine DNA glycosylase isoform 1

TDG Protein Structure

UDG

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

G/T mismatch-specific thymine DNA glycosylase

Related Diseases

Diseases

Alias

Cortical Deafness

Immunodeficiency With Hyper-Igm, Type 2

HIGM2	Hyper-Igm Syndrome Type 2
Hyper-Igm Syndrome 2	Immunodeficiency With Hyper-Igm Type 2
Activation-Induced Cytidine Deaminase Deficiency	Aid Deficiency
Immunodeficiency With Hyper Igm Type 2	Hyper Igm Syndrome 2
Immunodeficiency With Hyper-Igm 2	Hyper-Igm Immunodeficiency Type 2
Immunodeficiency, With Hyper Igm, Type 2	Hyper-Igm Immunodeficiency Syndrome, Type 2

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130208	Thiodigalactoside	Inhibitor	≥99.0%	Unkown
HY-RS14329	TDG Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TDG	VGNC	VGNC:78297
Mus musculus	TDG	MGD	MGI:108247
Felis catus	TDG	VGNC	VGNC:66043
Bos taurus	TDG	VGNC	VGNC:35711
Canis familiaris	TDG	VGNC	VGNC:47216
Rattus norvegicus	TDG	RGD	RGD:620959
Others	TDG	NCBI

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