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TDG - thymine DNA glycosylase Gene

Also Known as hTDG

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6996

About TDG

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:103,965,872-103,988,874 (from NCBI)

This gene has 10 transcripts (splice variants) and 284 orthologues. Ubiquitous expression in lymph node (RPKM 10.7), appendix (RPKM 8.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]

TDG Products (2)

mRNA	Protein	Name
NM_001363612.2	NP_001350541.1	G/T mismatch-specific thymine DNA glycosylase isoform 2
NM_003211.6	NP_003202.3	G/T mismatch-specific thymine DNA glycosylase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11889051	GOA
enables DNA N-glycosylase activity	IDA IDA: Inferred from direct assay	21862836	GOA
enables DNA N-glycosylase activity	IMP IMP: Inferred from mutant phenotype	18512959	GOA
enables G/U mismatch-specific uracil-DNA glycosylase activity	IMP IMP: Inferred from mutant phenotype	18512959	GOA
enables SUMO binding	IPI IPI: Inferred from physical interaction	15959518	GOA
enables chloride ion binding	IDA IDA: Inferred from direct assay	15959518	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	11889051	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	15959518	GOA
enables mismatched DNA binding	IDA IDA: Inferred from direct assay	11889051	GOA
enables nucleic acid binding	EXP EXP: Inferred from Experiment	18512959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15959518	GOA
enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity	IDA IDA: Inferred from direct assay	8662714	GOA
enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity	IMP IMP: Inferred from mutant phenotype	18512959	GOA
enables sodium ion binding	IDA IDA: Inferred from direct assay	15959518	GOA
enables uracil DNA N-glycosylase activity	IDA IDA: Inferred from direct assay	11889051	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in base-excision repair	IDA IDA: Inferred from direct assay	21862836	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	8662714	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TDG Protein Structure

UDG

0
100
200
300
410 a.a.

Protein Preferred Names	Protein Names
G/T mismatch-specific thymine DNA glycosylase

TDG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TDG	Q13569	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	TDG	Q13569	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	TDG	Q13569	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	TDG	Q13569	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	TDG	Q13569	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	TDG	Q13569	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	TDG	Q13569	AICDA	Homo sapiens	Q9GZX7	Anti Tag CoIP	21722948
Intra	TDG	Q13569	AICDA	Homo sapiens	Q9GZX7	Anti Bait CoIP	21722948
Intra	TDG	Q13569	GADD45A	Homo sapiens	P24522	Anti Bait CoIP	21722948
Intra	TDG	Q13569	GADD45A	Homo sapiens	P24522	Anti Tag CoIP	21722948
Intra	TDG	Q13569	NCOA1	Homo sapiens	Q15788	Pull Down	16282588
Intra	TDG	Q13569	NCOA1	Homo sapiens	Q15788	Anti Bait CoIP	16282588
Intra	TDG	Q13569	NCOA1	Homo sapiens	Q15788	CH-IP	16282588
Intra	TDG	Q13569	SUMO2	Homo sapiens	P61956	X-Ray Diffraction	16626738
Intra	TDG	Q13569	SUMO2	Homo sapiens	P61956	Pull Down	16626738
Intra	TDG	Q13569	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	TDG	Q13569	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	TDG	Q13569	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	TDG	Q13569	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	TDG	Q13569	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	TDG	Q13569	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	TDG	Q13569	NCOA1	Homo sapiens	Q15788-2	Pull Down	16282588
Intra	TDG	Q13569	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	TDG	Q13569	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	TDG	Q13569	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	TDG	Q13569	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	TDG	Q13569	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	TDG	Q13569	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	TDG	Q13569	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	TDG	Q13569	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	TDG	Q13569	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	TDG	Q13569	SUMO1	Homo sapiens	P63165	X-Ray Diffraction	15959518
Intra	TDG	Q13569	SUMO1	Homo sapiens	P63165	Pull Down	15959518

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cortical Deafness
Immunodeficiency With Hyper-Igm, Type 2	HIGM2 Hyper-Igm Syndrome Type 2 Hyper-Igm Syndrome 2 Immunodeficiency With Hyper-Igm Type 2 Activation-Induced Cytidine Deaminase Deficiency Aid Deficiency Immunodeficiency With Hyper Igm Type 2 Hyper Igm Syndrome 2 Immunodeficiency With Hyper-Igm 2 Hyper-Igm Immunodeficiency Type 2 Immunodeficiency, With Hyper Igm, Type 2 Hyper-Igm Immunodeficiency Syndrome, Type 2
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130208	Thiodigalactoside	Inhibitor	99.95%	Unkown
HY-126181	5-Formylcytosine		96.4%	Unkown
HY-181440	TDG-IN-1	Inhibitor	/	Unkown
HY-RS14329	TDG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17123	Tdg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23568	Tdg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TDG	VGNC	VGNC:78297
Mus musculus	TDG	MGD	MGI:108247
Felis catus	TDG	VGNC	VGNC:66043
Bos taurus	TDG	VGNC	VGNC:35711
Canis familiaris	TDG	VGNC	VGNC:47216
Rattus norvegicus	TDG	RGD	RGD:620959
Others	TDG	NCBI