NCOA1 - nuclear receptor coactivator 1 Gene

Also Known as SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8648

About NCOA1

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,491,254-24,770,702 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues, 2 paralogues and is associated with 83 phenotypes. Ubiquitous expression in brain (RPKM 17.5), testis (RPKM 14.8) and 25 other tissues.

Summary

The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (Src) family and like Other family members has Histone Acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

NCOA1 Products (7)

mRNA	Protein	Name
NM_001362950.1	NP_001349879.1	nuclear receptor coactivator 1 isoform 2
NM_001362952.1	NP_001349881.1	nuclear receptor coactivator 1 isoform 2
NM_001362954.1	NP_001349883.1	nuclear receptor coactivator 1 isoform 2
NM_001362955.1	NP_001349884.1	nuclear receptor coactivator 1 isoform 2
NM_003743.5	NP_003734.3	nuclear receptor coactivator 1 isoform 1
NM_147223.3	NP_671756.1	nuclear receptor coactivator 1 isoform 2
NM_147233.2	NP_671766.1	nuclear receptor coactivator 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	18563714	GOA
enables nuclear receptor binding	IDA IDA: Inferred from direct assay	10207113	GOA
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	17363140	GOA
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	15919756	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9556555	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	10207113	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in estrogen receptor signaling pathway	IDA IDA: Inferred from direct assay	7481822	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16373399	GOA
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11891224	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15367689	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9223431	GOA
involved in positive regulation of transcription from RNA polymerase II promoter by galactose	IDA IDA: Inferred from direct assay	10207113	GOA
involved in progesterone receptor signaling pathway	IDA IDA: Inferred from direct assay	10757795	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	16373399	GOA
located in chromatin	IDA IDA: Inferred from direct assay	15831516	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15641800	GOA
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	12909012	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCOA1 Protein Structure

PAS

PAS_11

SRC-1

Nuc_rec_co-act

DUF1518

0
300
600
900
1200
1441 a.a.

Protein Preferred Names	Protein Names
nuclear receptor coactivator 1	Hin-2 protein

NCOA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NCOA1	Q15788	PAGR1	Homo sapiens	Q9BTK6	Anti Bait CoIP	19039327
Intra	NCOA1	Q15788	PAGR1	Homo sapiens	Q9BTK6	Anti Tag CoIP	19039327
Intra	NCOA1	Q15788	KANK2	Homo sapiens	Q63ZY3	Pull Down	17476305
Intra	NCOA1	Q15788	VDR	Homo sapiens	P11473	GMS	21478865
Intra	NCOA1	Q15788	VDR	Homo sapiens	P11473	Solution Sedimentation	21478865
Intra	NCOA1	Q15788	TDG	Homo sapiens	Q13569	CH-IP	16282588
Intra	NCOA1	Q15788	TDG	Homo sapiens	Q13569	Pull Down	16282588
Intra	NCOA1	Q15788	NR1I2	Homo sapiens	O75469	X-Ray Diffraction	23602807
Intra	NCOA1	Q15788	NR1I2	Homo sapiens	O75469	FPS	23602807
Intra	NCOA1	Q15788	RARA	Homo sapiens	P10276	Y2H	17641689
Intra	NCOA1	Q15788	RARA	Homo sapiens	P10276	Solution Sedimentation	21478865
Intra	NCOA1	Q15788	RARA	Homo sapiens	P10276	GMS	21478865
Intra	NCOA1	Q15788	PSMB9	Homo sapiens	P28065	Anti Bait CoIP	16957778
Intra	NCOA1	Q15788	PSMB9	Homo sapiens	P28065	Y2H	16957778
Intra	NCOA1	Q15788	PSMB9	Homo sapiens	P28065	Pull Down	16957778
Cross	NCOA1	Q15788	Nfkb1	Mus musculus	P25799	Y2H	9556555
Cross	NCOA1	Q15788	Nfkb1	Mus musculus	P25799	Pull Down	9556555
Intra	NCOA1	Q15788	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	NCOA1	Q15788	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	NCOA1	Q15788	NR1H3	Homo sapiens	Q13133	Y2H	20682316
Intra	NCOA1	Q15788	NR1H3	Homo sapiens	Q13133	Pull Down	20682316
Intra	NCOA1	Q15788	ESR1	Homo sapiens	P03372	Y2H	16606617
Intra	NCOA1	Q15788	ESR1	Homo sapiens	P03372	Pull Down	11682626
Intra	NCOA1	Q15788	ESR1	Homo sapiens	P03372	Y2H	17627277
Intra	NCOA1	Q15788	ESR1	Homo sapiens	P03372	Pull Down	16957778
Intra	NCOA1	Q15788	RXRA	Homo sapiens	P19793	X-Ray Diffraction	23602807
Intra	NCOA1	Q15788	RXRA	Homo sapiens	P19793	GMS	21478865
Intra	NCOA1	Q15788	RXRA	Homo sapiens	P19793	Pull Down	20682316
Intra	NCOA1	Q15788	RXRA	Homo sapiens	P19793	Solution Sedimentation	21478865
Intra	NCOA1	Q15788	RXRA	Homo sapiens	P19793	FPS	23602807
Intra	NCOA1	Q15788	NR1H4	Homo sapiens	Q96RI1-2	SPR	14698205

Cross: Cross-species interaction Intra: Intraspecies interaction

NCOA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80339	KAT13A/SRC1 Antibody (YA060)	WB, IHC-P, IP	Human
HY-P81990	KAT13A/SRC1 Antibody (YA1735)	WB, IHC-P, IP	Human
HY-P81990A	KAT13A/SRC1 Antibody (YA1735)(PBS only)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Rhabdomyosarcoma
Endometrial Hyperplasia
Chondroid Lipoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173033	MI-883		99.57%	Unkown
HY-RS09089	NCOA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-146288	LXR agonist 2	Agonist	/	Unkown
HY-RS22672	Ncoa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NCOA1	VGNC	VGNC:75145
Mus musculus	NCOA1	MGD	MGI:1276523
Canis familiaris	NCOA1	VGNC	VGNC:43659
Rattus norvegicus	NCOA1	RGD	RGD:1309046
Bos taurus	NCOA1	VGNC	VGNC:97291
Felis catus	NCOA1	VGNC	VGNC:68431
Others	NCOA1	NCBI