RXRA - retinoid X receptor alpha Gene

Also Known as NR2B1; RXRalpha; RXR-alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6256

About RXRA

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:134,326,455-134,440,585 (from NCBI)

This gene has 5 transcripts (splice variants), 247 orthologues and 11 paralogues. Ubiquitous expression in skin (RPKM 34.2), fat (RPKM 23.2) and 25 other tissues.

Summary

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and Thyroid Hormone Receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

RXRA Products (3)

mRNA	Protein	Name
NM_001291920.2	NP_001278849.1	retinoic acid receptor RXR-alpha isoform b
NM_001291921.2	NP_001278850.1	retinoic acid receptor RXR-alpha isoform c
NM_002957.6	NP_002948.1	retinoic acid receptor RXR-alpha isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding domain binding	IDA IDA: Inferred from direct assay	19043829	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12037571	GOA
enables LBD domain binding	IDA IDA: Inferred from direct assay	19043829	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12037571	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7831303	GOA
enables double-stranded DNA binding	IMP IMP: Inferred from mutant phenotype	19043829	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	12039952	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	7831303	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	1651173	GOA
enables nuclear vitamin D receptor binding	IPI IPI: Inferred from physical interaction	17426122	GOA
enables peptide binding	IDA IDA: Inferred from direct assay	19043829	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9653119	GOA
enables retinoic acid binding	IDA IDA: Inferred from direct assay	18690216	GOA
enables retinoic acid-responsive element binding	IDA IDA: Inferred from direct assay	19917671	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11915042	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18511497	GOA
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	14701856	GOA
contributes to vitamin D response element binding	IDA IDA: Inferred from direct assay	17426122	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19043829	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	7744246	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1309942	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17426122	GOA
involved in peroxisome proliferator activated receptor signaling pathway	IDA IDA: Inferred from direct assay	10195690	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1651173	GOA
involved in positive regulation of thyroid hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	1310350	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12037571	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1309942	GOA
involved in positive regulation of vitamin D receptor signaling pathway	IDA IDA: Inferred from direct assay	20171278	GOA
involved in response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17538076	GOA
involved in retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	1309942	GOA
involved in retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17538076	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	19167885	GOA
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	1310351	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	10669605	GOA
located in chromatin	IDA IDA: Inferred from direct assay	9267036	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7990953	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	17426122	GOA
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	10698945	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RXRA Protein Structure

Nuc_recep-AF1

zf-C4

Hormone_recep

0
100
200
300
400
462 a.a.

Protein Preferred Names	Protein Names
retinoic acid receptor RXR-alpha	nuclear receptor subfamily 2 group B member 1

RXRA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RXRA	P19793	STAT1	Homo sapiens	P42224	Y2H	21988832
Intra	RXRA	P19793	PPARG	Homo sapiens	P37231-1	Pull Down	21478865
Intra	RXRA	P19793	PPARG	Homo sapiens	P37231-1	GMS	21478865
Intra	RXRA	P19793	PPARG	Homo sapiens	P37231-1	SAXS	21478865
Intra	RXRA	P19793	NR1H2	Homo sapiens	P55055-1	SPR	15722453
Intra	RXRA	P19793	VDR	Homo sapiens	P11473	Y2H	21988832
Intra	RXRA	P19793	VDR	Homo sapiens	P11473	GMS	21478865
Intra	RXRA	P19793	VDR	Homo sapiens	P11473	SAXS	21478865
Intra	RXRA	P19793	VDR	Homo sapiens	P11473	Solution Sedimentation	21478865
Intra	RXRA	P19793	VDR	Homo sapiens	P11473	Pull Down	21478865
Intra	RXRA	P19793	MED1	Homo sapiens	Q15648	Pull Down	9653119
Intra	RXRA	P19793	MED25	Homo sapiens	Q71SY5	Y2H	17641689
Intra	RXRA	P19793	MED25	Homo sapiens	Q71SY5	Pull Down	17641689
Intra	RXRA	P19793	MED25	Homo sapiens	Q71SY5	Anti Bait CoIP	17641689
Intra	RXRA	P19793	FUS	Homo sapiens	P35637	Y2H Pooling	32814053
Intra	RXRA	P19793	FUS	Homo sapiens	P35637	Validated Y2H	32814053
Intra	RXRA	P19793	FUS	Homo sapiens	P35637	Y2H Array	32814053
Intra	RXRA	P19793	RARA	Homo sapiens	P10276	Y2H	21988832
Intra	RXRA	P19793	RARA	Homo sapiens	P10276	PLA	25241761
Intra	RXRA	P19793	RARA	Homo sapiens	P10276	Pull Down	19345331
Intra	RXRA	P19793	RARA	Homo sapiens	P10276	X-Ray Diffraction	10698945
Intra	RXRA	P19793	NCOA1	Homo sapiens	Q15788	SPR	17673910
Intra	RXRA	P19793	NCOA1	Homo sapiens	Q15788	Pull Down	20682316
Intra	RXRA	P19793	NCOA1	Homo sapiens	Q15788	FPS	23602807
Intra	RXRA	P19793	BHLHE40	Homo sapiens	O14503	Crosslink	29234281
Intra	RXRA	P19793	NR1H2	Homo sapiens	P55055	GMS	24561505
Intra	RXRA	P19793	NR1H2	Homo sapiens	P55055	Y2H Array	20211142
Intra	RXRA	P19793	NR1H3	Homo sapiens	Q13133	SPR	15722453
Intra	RXRA	P19793	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	20541701
Intra	RXRA	P19793	PIK3R1	Homo sapiens	P27986	Anti Tag CoIP	20541701
Intra	RXRA	P19793	PIK3R1	Homo sapiens	P27986	Confocal	20541701
Intra	RXRA	P19793	NCOA2	Homo sapiens	Q15596	X-Ray Diffraction	17947383
Intra	RXRA	P19793	NCOA2	Homo sapiens	Q15596	Y2H	17947383
Cross	RXRA	P19793	Ncoa6	Rattus norvegicus	Q9JLI4	Pull Down	10866662

Cross: Cross-species interaction Intra: Intraspecies interaction

RXRA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80309	Retinoid X Receptor alpha Antibody (YA095)	WB, ICC/IF, IHC-P, IP	Human, Rat

Related Diseases

Diseases	Alias
Bladder Urothelial Carcinoma	Bladder Transitional Cell Carcinoma Transitional Cell Carcinoma Of Bladder Transitional Cell Carcinoma Of The Bladder Urinary Bladder Urothelial Carcinoma Urothelial Bladder Carcinoma Carcinoma Transitional Cell Bladder Tcc - [Transitional Cell Carcinoma] Of Bladder
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Cholestasis	Obstruction Of Bile Duct Bile Duct Obstruction Bile Occlusion Extrahepatic Biliary Obstruction Extrahepatic Bile Duct Obstruction Bile Stasis Biliary Stasis Obstructive Hyperbilirubinemia Obstructed Jaundice Bile Duct Obstructed Bile Ductal Obstruction Biliary Duct Obstruction Obstructed Bile Ductal Obstructed Biliary Duct Obstructed Biliary Ductal Jaundice Regurgitation Obstructive Jaundice Cholestatic Jaundice Cholestatic Jaundice Syndrome
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Trichothiodystrophy 7, Nonphotosensitive	TTD7 Nonphotosensitive Trichothiodystrophy 7 Trichothiodystrophy 7, Non-Photosensitive
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12361	RXRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-182415	RX-RA-69	Inhibitor	/	Unkown
HY-160212	JP3000	Agonist	/	Unkown
HY-RS17966	Rxra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24437	Rxra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RXRA	VGNC	VGNC:34230
Felis catus	RXRA	VGNC	VGNC:64834
Rattus norvegicus	RXRA	RGD	RGD:3610
Canis familiaris	RXRA	VGNC	VGNC:45817
Mus musculus	RXRA	MGD	MGI:98214
Macaca mulatta	RXRA	VGNC	VGNC:76951
Others	RXRA	NCBI