MED25 - mediator complex subunit 25 Gene

Also Known as P78; ACID1; ARC92; BVSYS; PTOV2; CMT2B2; TCBAP0758

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81857

About MED25

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,818,289-49,840,384 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 6 phenotypes. Broad expression in testis (RPKM 24.2), adrenal (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]

MED25 Products (2)

mRNA	Protein	Name
NM_001378355.1	NP_001365284.1	mediator of RNA polymerase II transcription subunit 25 isoform 2
NM_030973.4	NP_112235.2	mediator of RNA polymerase II transcription subunit 25 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear retinoic acid receptor binding	IPI IPI: Inferred from physical interaction	17641689	GOA
enables nuclear retinoid X receptor binding	IPI IPI: Inferred from physical interaction	17641689	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17641689	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	17641689	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	17641689	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17641689	GOA
involved in positive regulation of chromatin binding	IMP IMP: Inferred from mutant phenotype	17641689	GOA
involved in positive regulation of mediator complex assembly	IMP IMP: Inferred from mutant phenotype	17641689	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17641689	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED25 Protein Structure

Med25_VWA

Med25_SD1

Med25

Med25_NR-box

0
200
400
600
747 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 25	ARC/mediator transcriptional coactivator subunit

MED25 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MED25	Q71SY5	ESRP1	Homo sapiens	Q6NXG1	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	ESRP1	Homo sapiens	Q6NXG1	Y2H Array	32296183
Intra	MED25	Q71SY5	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Array	32296183
Intra	MED25	Q71SY5	NCKIPSD	Homo sapiens	Q9NZQ3-3	Validated Y2H	32296183
Intra	MED25	Q71SY5	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	MED25	Q71SY5	STAT5B	Homo sapiens	P51692	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	STAT5B	Homo sapiens	P51692	Y2H Array	32296183
Intra	MED25	Q71SY5	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	MED25	Q71SY5	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	MED25	Q71SY5	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	MED25	Q71SY5	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	MED25	Q71SY5	FAM168B	Homo sapiens	A1KXE4-2	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	FAM168B	Homo sapiens	A1KXE4-2	Y2H Array	32296183
Intra	MED25	Q71SY5	EYA2	Homo sapiens	O00167-2	Y2H Array	32296183
Intra	MED25	Q71SY5	EYA2	Homo sapiens	O00167-2	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	MED25	Q71SY5	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	OXER1	Homo sapiens	Q8TDS5	Validated Y2H	32296183
Intra	MED25	Q71SY5	RORB	Homo sapiens	Q92753-1	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	RORB	Homo sapiens	Q92753-1	Validated Y2H	32296183
Intra	MED25	Q71SY5	RORB	Homo sapiens	Q92753-1	Y2H Array	32296183
Intra	MED25	Q71SY5	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	MED25	Q71SY5	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	MED23	Homo sapiens	Q9ULK4	Anti Tag CoIP	24882805
Intra	MED25	Q71SY5	MED23	Homo sapiens	Q9ULK4	Anti Tag CoIP	25792360
Intra	MED25	Q71SY5	TFG	Homo sapiens	Q92734	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	MED25	Q71SY5	TFG	Homo sapiens	Q92734	Y2H Array	32296183
Intra	MED25	Q71SY5	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	MED25	Q71SY5	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	MED25	Q71SY5	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	MED25	Q71SY5	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	MED14	Homo sapiens	O60244	Anti Tag CoIP	24882805
Intra	MED25	Q71SY5	MED14	Homo sapiens	O60244	Anti Tag CoIP	25792360
Intra	MED25	Q71SY5	MED15	Homo sapiens	Q96RN5	Anti Tag CoIP	24882805
Intra	MED25	Q71SY5	MED24	Homo sapiens	O75448	Anti Tag CoIP	35271311
Intra	MED25	Q71SY5	MED24	Homo sapiens	O75448	Anti Tag CoIP	25792360
Intra	MED25	Q71SY5	MED16	Homo sapiens	Q9Y2X0	Anti Tag CoIP	25792360
Intra	MED25	Q71SY5	MED16	Homo sapiens	Q9Y2X0	Anti Tag CoIP	35271311
Intra	MED25	Q71SY5	RARA	Homo sapiens	P10276	Y2H	17641689
Intra	MED25	Q71SY5	ODAM	Homo sapiens	A1E959	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	ODAM	Homo sapiens	A1E959	Y2H Array	32296183
Intra	MED25	Q71SY5	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	MED25	Q71SY5	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	MED25	Q71SY5	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	MED25	Q71SY5	PEF1	Homo sapiens	Q9UBV8	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	PEF1	Homo sapiens	Q9UBV8	Y2H Array	32296183
Intra	MED25	Q71SY5	HGS	Homo sapiens	O14964	Y2H Array	32296183
Intra	MED25	Q71SY5	HGS	Homo sapiens	O14964	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	MED25	Q71SY5	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	WWP2	Homo sapiens	O00308	Y2H Array	32296183
Intra	MED25	Q71SY5	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	MED25	Q71SY5	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	MED25	Q71SY5	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	RXRA	Homo sapiens	P19793	Anti Tag CoIP	17641689
Intra	MED25	Q71SY5	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	MED25	Q71SY5	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Cross	MED25	Q71SY5	UL48	Human herpesvirus 1	G8HBG2	Pull Down	21378963
Cross	MED25	Q71SY5	UL48	Human herpesvirus 1	G8HBG2	ITC	21378963
Cross	MED25	Q71SY5	UL48	Human herpesvirus 1	G8HBG2	NMR	21378963
Cross	MED25	Q71SY5	UL48	Human herpesvirus 1	G8HBG2	EMSA	21378965
Cross	MED25	Q71SY5	UL48	Human herpesvirus 1	G8HBG2	NMR	21378965

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Basel-Vanagaite-Smirin-Yosef Syndrome	BVSYS Basel-Vanagait-Smirin-Yosef Syndrome
Charcot-Marie-Tooth Disease, Axonal, Type 2b2	Charcot-Marie-Tooth Disease Type 2b2 CMT2B2 Arcmt2b Charcot-Marie-Tooth Disease, Type 2b2 Ar-Cmt2b2 Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b2 Autosomal Recessive Axonal Cmt4c3 Charcot-Marie-Tooth Disease Neuronal Type 2b2 Charcot-Marie-Tooth Neuropathy Type 2b2 Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b2 Charcot-Marie-Tooth Disease, Neuronal, Type 2b2 Charcot-Marie-Tooth Neuropathy, Type 2b2 Charcot-Marie-Tooth Disease 2b2 Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B2 Charcot-Marie-Tooth Disease Axonal Type 2b2
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Tooth Disease	Tooth Diseases Teeth Disease Tooth Disorders
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Charcot-Marie-Tooth Disease, Axonal, Type 2i	CMT2I Charcot-Marie-Tooth Disease, Type 2i Charcot-Marie-Tooth Disease Type 2i Charcot-Marie-Tooth Neuropathy Type 2i Charcot-Marie-Tooth Neuropathy, Type 2i Autosomal Dominant Charcot-Marie-Tooth Disease Type 2i Charcot-Marie-Tooth Disease 2i Charcot-Marie-Tooth Disease Axonal Type 2i Charcot-Marie-Tooth Disease Neuronal Type 2i
Charcot-Marie-Tooth Disease And Deafness	Charcot-Marie-Tooth Disease Type 1e CMT1E Charcot-Marie-Tooth Disease Type 1 Hereditary Motor And Sensory Neuropathy Type 1 Charcot-Marie-Tooth Disease, Demyelinating, Type 1e Charcot-Marie-Tooth Disease, Type I Charcot-Marie-Tooth Neuropathy And Deafness, Autosomal Dominant Charcot-Marie-Tooth Disease, Type 1e Charcot-Marie-Tooth Disease Demyelinating Type 1e Autosomal Dominant Demyelinating Charcot-Marie-Tooth Disease Cmt1 Charcot-Marie-Tooth Neuropathy Type 1 Autosomal Dominant Charcot-Marie-Tooth Neuropathy And Deafness Charcot-Marie-Tooth Disease-Deafness Charcot-Marie-Tooth Type 1 Hmsn1 Hereditary Motor And Sensory Neuropathy 1 Cmt 1e Charcot Marie Tooth Disease Type 1e Charcot-Marie-Tooth Disease-Deafness Syndrome Charcot-Marie-Tooth Disease-Hearing Loss Syndrome Charcot-Marie-Tooth Disease 1e Charcot-Marie-Tooth Disease And Deafness Autosomal Dominant Charcot-Marie-Tooth Neuropathy Type 1e Charcot-Marie-Tooth Disease, Type Ie Hereditary Motor And Sensory Neuropathy Type I
Male Reproductive Organ Benign Neoplasm
Polymicrogyria	Pmg
Prostatic Adenoma	Prostatic Hyperplasia Adenoma - Prostate Adenoma Of Prostate Benign Adenoma Of Prostate Prostate Adenoma Benign Prostatic Hyperplasia
Polymicrogyria, Bilateral Perisylvian, X-Linked	Bilateral Perisylvian Polymicrogyria Polymicrogyria, Bilateral Perisylvian Pmgx Perisylvian Syndrome, Congenital Bilateral Cbps Congenital Bilateral Perisylvian Syndrome Perisylvian Syndrome BPPX Bpp
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv
Hypertrophic Neuropathy Of Dejerine-Sottas	Dejerine-Sottas Disease Dejerine-Sottas Syndrome Charcot-Marie-Tooth Disease Type 3 DSS Hereditary Motor And Sensory Neuropathy Type Iii Hmsn3 Dejerine-Sottas Neuropathy Hmsn Iii Charcot-Marie-Tooth Disease, Type 3 Cmt3 Dsn Hmsn 3 Hereditary Motor And Sensory Neuropathy Type 3 Hereditary Motor And Sensory Neuropathy 3 Hypertrophic Neuropathy Of Infancy Charcot-Marie-Tooth Disease Demyelinating Type 4f Charcot-Marie-Tooth Disease Type 4f Charcot-Marie-Tooth Neuropathy Type 4f Cmt4f Hereditary Motor And Sensory Neuropathy Iii Charcot-Marie-Tooth Disease, Demyelinating, Type 4f
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158104	LPPM-8	Inhibitor	/	Unkown
HY-RS08296	MED25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08307	MED9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18774	Med9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MED25	MGD	MGI:1922863
Canis familiaris	MED25	VGNC	VGNC:43133
Felis catus	MED25	VGNC	VGNC:63439
Rattus norvegicus	MED25	RGD	RGD:1305137
Bos taurus	MED25	VGNC	VGNC:31362
Macaca mulatta	MED25	VGNC	VGNC:74607
Others	MED25	NCBI