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MED15 - mediator complex subunit 15 Gene

Also Known as TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51586

About MED15

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,507,610-20,587,619 (from NCBI)

This gene has 31 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in spleen (RPKM 10.5), bone marrow (RPKM 9.5) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

MED15 Products (6)

mRNA	Protein	Name
NM_001003891.3	NP_001003891.1	mediator of RNA polymerase II transcription subunit 15 isoform a
NM_001293234.2	NP_001280163.1	mediator of RNA polymerase II transcription subunit 15 isoform c
NM_001293235.2	NP_001280164.1	mediator of RNA polymerase II transcription subunit 15 isoform d
NM_001293236.2	NP_001280165.1	mediator of RNA polymerase II transcription subunit 15 isoform e
NM_001293237.2	NP_001280166.1	mediator of RNA polymerase II transcription subunit 15 isoform d
NM_015889.5	NP_056973.2	mediator of RNA polymerase II transcription subunit 15 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16799563	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED15 Protein Structure

Med15

0
200
400
600
788 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 15	CTG repeat protein 7a

MED15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MED15	Q96RN5	MED14	Homo sapiens	O60244	Anti Tag CoIP	24882805
Intra	MED15	Q96RN5	MED25	Homo sapiens	Q71SY5	Anti Tag CoIP	24882805
Intra	MED15	Q96RN5	SREBF2	Homo sapiens	Q12772	Pull Down	16799563
Intra	MED15	Q96RN5	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	MED15	Q96RN5	TRIM11	Homo sapiens	Q96F44	Imaging	16904669
Intra	MED15	Q96RN5	TRIM11	Homo sapiens	Q96F44	Anti Tag CoIP	16904669
Intra	MED15	Q96RN5	SREBF1	Homo sapiens	P36956-1	Pull Down	18385733
Intra	MED15	Q96RN5	SREBF1	Homo sapiens	P36956-3	Pull Down	16799563

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Digeorge Syndrome	Chromosome 22q11.2 Deletion Syndrome DGS Hypoplasia Of Thymus And Parathyroids Third And Fourth Pharyngeal Pouch Syndrome 22q11.2 Deletion Syndrome Digeorge Sequence Digeorge'S Syndrome Pharyngeal Pouch Syndrome Di-George Syndrome Shprintzen Syndrome
Ureterocele
Velocardiofacial Syndrome	Shprintzen Syndrome VCFS Chromosome 22q11.2 Deletion Syndrome Vcf Syndrome Shprintzen Vcf Syndrome Vcf-Velocardiofacial Syndrome Velo-Cardio-Facial Syndrome Digeorge Syndrome 22q11 Deletion Syndrome Conotruncal Anomaly Face Syndrome
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173353	ATXN1-MED15 PPI-IN-1	Modulator	/	Unkown
HY-RS08286	MED15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MED15	VGNC	VGNC:74511
Rattus norvegicus	MED15	RGD	RGD:1307560
Canis familiaris	MED15	VGNC	VGNC:43125
Mus musculus	MED15	MGD	MGI:2137379
Bos taurus	MED15	VGNC	VGNC:31353
Others	MED15	NCBI