MED23 - mediator complex subunit 23 Gene

Also Known as SUR2; CRSP3; MRT18; SUR-2; ARC130; CRSP130; CRSP133; DRIP130

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9439

About MED23

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,573,966-131,628,313 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 9.5), lymph node (RPKM 8.5) and 25 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of Other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]

MED23 Products (12)

mRNA	Protein	Name
NM_001270521.2	NP_001257450.1	mediator of RNA polymerase II transcription subunit 23 isoform c
NM_001270522.2	NP_001257451.1	mediator of RNA polymerase II transcription subunit 23 isoform d
NM_001376517.1	NP_001363446.1	mediator of RNA polymerase II transcription subunit 23 isoform e
NM_001376518.1	NP_001363447.1	mediator of RNA polymerase II transcription subunit 23 isoform f
NM_001376519.1	NP_001363448.1	mediator of RNA polymerase II transcription subunit 23 isoform g
NM_001376520.1	NP_001363449.1	mediator of RNA polymerase II transcription subunit 23 isoform h
NM_001376521.1	NP_001363450.1	mediator of RNA polymerase II transcription subunit 23 isoform i
NM_001376522.1	NP_001363451.1	mediator of RNA polymerase II transcription subunit 23 isoform j
NM_001376523.1	NP_001363452.1	mediator of RNA polymerase II transcription subunit 23 isoform k
NM_001376524.1	NP_001363453.1	mediator of RNA polymerase II transcription subunit 23 isoform l
NM_004830.4	NP_004821.2	mediator of RNA polymerase II transcription subunit 23 isoform a
NM_015979.4	NP_057063.2	mediator of RNA polymerase II transcription subunit 23 isoform b

MED23 Protein Structure

Med23

0
300
600
900
1200
1368 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 23	130 kDa transcriptional co-activator

MED23 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MED23	Q9ULK4	MED13	Homo sapiens	Q9UHV7	Y2H	12421765
Intra	MED23	Q9ULK4	MED13	Homo sapiens	Q9UHV7	Anti Tag CoIP	33961781
Intra	MED23	Q9ULK4	MED13	Homo sapiens	Q9UHV7	BioID	25281560
Intra	MED23	Q9ULK4	MED14	Homo sapiens	O60244	Anti Tag CoIP	24882805
Intra	MED23	Q9ULK4	MED14	Homo sapiens	O60244	BioID	25281560
Intra	MED23	Q9ULK4	MED14	Homo sapiens	O60244	Pull Down	25281560
Intra	MED23	Q9ULK4	MED14	Homo sapiens	O60244	Anti Tag CoIP	33961781
Intra	MED23	Q9ULK4	MED16	Homo sapiens	Q9Y2X0	BioID	25281560
Intra	MED23	Q9ULK4	MED16	Homo sapiens	Q9Y2X0	Pull Down	25281560
Intra	MED23	Q9ULK4	MED16	Homo sapiens	Q9Y2X0	Anti Tag CoIP	33961781
Intra	MED23	Q9ULK4	MED25	Homo sapiens	Q71SY5	Anti Tag CoIP	33961781
Intra	MED23	Q9ULK4	MED25	Homo sapiens	Q71SY5	BioID	25281560
Intra	MED23	Q9ULK4	MED25	Homo sapiens	Q71SY5	Pull Down	25281560

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Recessive 18, With Or Without Epilepsy	Intellectual Developmental Disorder, Autosomal Recessive 18 MRT18 Mental Retardation, Autosomal Recessive 18 Autosomal Recessive Intellectual Developmental Disorder 18 Mental Retardation, Autosomal Recessive, Type 18
Med23	Intellectual Disability, Autosomal Recessive 18 Autosomal Recessive Nonsyndromic Intellectual Disability-18
Argininemia	Hyperargininemia Arginase Deficiency Arg1 Deficiency Arginase-1 Deficiency Deficiency Of Canavanase Arginase Deficiency Disease ARGIN
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid
Homocystinuria-Megaloblastic Anemia, Cblg Complementation Type	Methylcobalamin Deficiency, Cblg Type HMAG Methionine Synthase Deficiency Methylcobalamin Deficiency Type Cblg Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism, Cblg Complementation Type Homocystinuria-Megaloblastic Anemia Cblg Type Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cblg Complementation Type Methylcobalamin Deficiency Cbl G Type Homocystinuria Due To Defect In Methylation Cbl G Cblg Functional Methionine Synthase Deficiency Type Cblg Methylcobalamin Deficiency Cblg Type Arakawa Syndrome 2
Opitz-Kaveggia Syndrome	Fg Syndrome Fgs1 Fgs Keller Syndrome OKS Fg Syndrome 1 Fg Syndrome Type 1 Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158005	Anticancer agent 195	Inducer	/	Unkown
HY-RS08294	MED23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MED23	VGNC	VGNC:43131
Bos taurus	MED23	VGNC	VGNC:31360
Mus musculus	MED23	MGD	MGI:1917458
Rattus norvegicus	MED23	RGD	RGD:1307671
Macaca mulatta	MED23	VGNC	VGNC:74562
Felis catus	MED23	VGNC	VGNC:102459
Others	MED23	NCBI