Anticancer agent 195
Anticancer agent 195 (Compound 10) is an inhibitor for ELF3-MED23 PPI with Ki of 0.68 μM. Anticancer agent 195 induces apoptosis and exhibits antitumor activity.
For research use only. We do not sell to patients.
- Formula: C24H28O6
- Molecular Weight:412.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
>Ki: 0.68 μM (ELF3-MED23 PPI)
Anticancer agent 195 (10 μM) blocks the ELF3-MED23 interaction, inhibits activity of HER2 promoter and followed phosphorylation of AKT and MAPK[1].
Anticancer agent 195 (10 μM) reveals an anti-proliferative and apoptotic-inducing efficacy in cells NCI-N87, exhibits potency against trastuzumab resistance[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:NCI-N87, NCI-N87 TR
-
Concentration:0-10 μM
-
Incubation Time:16 h
-
Result:Reduced levels of HER2, phosphorylated AKT and p-MAPK.
Increased cleaved PARP and c-caspase 3.
-
Cell Line:NCI-N87, NCI-N87 TR
-
Concentration:0-15 μM
-
Incubation Time:24 h
-
Result:Induced apoptosis in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:NCI-N87 xenograft athymic nude mice[1]
-
Dosage:4 mg/kg
-
Administration:i.v., every three days for 25 days
-
Result:Inhibited tumor growth.
Chemical Information
-
Molecular Weight 412.48
-
Formula C24H28O6
-
SMILES
COC1=CC(C(/C=C/C2=CC=C(C(OC/C=C(C)\C)=C2)OC)=O)=CC(OC)=C1OC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz