2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 195

Anticancer agent 195 (Compound 10) is an inhibitor for ELF3-MED23 PPI with Ki of 0.68 μM. Anticancer agent 195 induces apoptosis and exhibits antitumor activity.

For research use only. We do not sell to patients.

Anticancer agent 195 Chemical Structure

Anticancer agent 195 Chemical Structure

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Anticancer agent 195 Related Antibodies

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Description

Anticancer agent 195 (Compound 10) is an inhibitor for ELF3-MED23 PPI with Ki of 0.68 μM. Anticancer agent 195 induces apoptosis and exhibits antitumor activity[1].

IC50 & Target

>Ki: 0.68 μM (ELF3-MED23 PPI)
In Vitro

Anticancer agent 195 (10 μM) blocks the ELF3-MED23 interaction, inhibits activity of HER2 promoter and followed phosphorylation of AKT and MAPK[1].
Anticancer agent 195 (10 μM) reveals an anti-proliferative and apoptotic-inducing efficacy in cells NCI-N87, exhibits potency against trastuzumab resistance[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 195 Related Antibodies

Western Blot Analysis[1]

Cell Line: NCI-N87, NCI-N87 TR
Concentration: 0-10 μM
Incubation Time: 16 h
Result: Reduced levels of HER2, phosphorylated AKT and p-MAPK.
Increased cleaved PARP and c-caspase 3.

Apoptosis Analysis[1]

Cell Line: NCI-N87, NCI-N87 TR
Concentration: 0-15 μM
Incubation Time: 24 h
Result: Induced apoptosis in a dose-dependent manner.
In Vivo

Anticancer agent 195 (4 mg/kg, i.v. for 25 days) inhibited tumor growth in NCI-N87 xenograft athymic nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-N87 xenograft athymic nude mice[1]
Dosage: 4 mg/kg
Administration: i.v., every three days for 25 days
Result: Inhibited tumor growth.
Molecular Weight

412.48

Formula

C24H28O6
SMILES

COC1=CC(C(/C=C/C2=CC=C(C(OC/C=C(C)\C)=C2)OC)=O)=CC(OC)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 195 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 195Anticancer agent195Anticancer agent-195Apoptosisgastric cancerHER2NCI-N87trastuzumab resistanceTRNCI-N87 TRathymic nude miceInhibitorinhibitorinhibit

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