ODAM - odontogenic, ameloblast associated Gene

Also Known as APIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54959

About ODAM

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,195,725-70,204,576 (from NCBI)

This gene has 6 transcripts (splice variants) and 89 orthologues. Restricted expression toward salivary gland (RPKM 78.4).

Summary

Involved in several processes, including positive regulation of GTPase activity; positive regulation of epithelial cell proliferation involved in wound healing; and positive regulation of macromolecule metabolic process. Located in several cellular components, including extracellular space; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ODAM Products (2)

mRNA	Protein	Name
NM_001385579.1	NP_001372508.1	odontogenic ameloblast-associated protein isoform 2 precursor
NM_017855.4	NP_060325.3	odontogenic ameloblast-associated protein isoform 1 precursor

ODAM Protein Structure

ODAM

0
100
200
279 a.a.

Protein Preferred Names	Protein Names
odontogenic ameloblast-associated protein	odontogenic, ameloblast asssociated

ODAM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ODAM	A1E959	VENTX	Homo sapiens	O95231	Validated Y2H	32296183
Intra	ODAM	A1E959	ADAM15	Homo sapiens	Q13444-2	Validated Y2H	32296183
Intra	ODAM	A1E959	SPATA31A7	Homo sapiens	Q8IWB4	Validated Y2H	32296183
Intra	ODAM	A1E959	MED25	Homo sapiens	Q71SY5	Validated Y2H	32296183
Intra	ODAM	A1E959	FHL2	Homo sapiens	Q14192	Anti Tag CoIP	33961781
Intra	ODAM	A1E959	FHL2	Homo sapiens	Q14192	Anti Tag CoIP	28514442
Intra	ODAM	A1E959	SDCBP	Homo sapiens	O00560	Validated Y2H	32296183
Intra	ODAM	A1E959	HGS	Homo sapiens	O14964	Validated Y2H	32296183
Intra	ODAM	A1E959	SNRPC	Homo sapiens	P09234	Validated Y2H	32296183
Intra	ODAM	A1E959	ARID5A	Homo sapiens	Q03989	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Amelogenesis Imperfecta, Type Iiia	Ai3 Adhcai Amelogenesis Imperfecta Type 3 AI3A Amelogenesis Imperfecta, Type Iii Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant Amelogenesis Imperfecta Type 3a Amelogenesis Imperfecta Hypomineralization Type Amelogenesis Imperfecta Type Iii Hypocalcified Amelogenesis Imperfecta Amelogenesis Imperfecta, Type 3 Amelogenesis Imperfecta, Hypomineralization Type Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3a Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant
Bone Benign Neoplasm
Crisponi/Cold-Induced Sweating Syndrome 1	Crisponi Syndrome Cold-Induced Sweating Syndrome 1 CISS1 Sohar-Crisponi Syndrome Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death Muscle Contractions Tetanoform With Characteristic Face Camptodactyly Hyperthermia And Sudden Death
Dental Fluorosis	Mottled Teeth Intrinsic Enamel Discolouration Of Fluorosis Mottling Of Enamel Fluorosis, Dental Dental Fluorosis, Acquired
Cold-Induced Sweating Syndrome	Crisponi Syndrome Sohar-Crisponi Syndrome Ciss Cntf Receptor-Related Disorders Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death Sweating Syndrome, Cold-Induced
Gingival Fibromatosis	Hereditary Gingival Fibromatosis Hereditary Gingival Hyperplasia Autosomal Dominant Gingival Fibromatosis Autosomal Dominant Gingival Hyperplasia Fibromatosis, Gingival, Hereditary Fibromatosis, Gingival
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09748	ODAM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ODAM	RGD	RGD:1561883
Canis familiaris	ODAM	VGNC	VGNC:44096
Mus musculus	ODAM	MGD	MGI:1916842
Felis catus	ODAM	VGNC	VGNC:63948
Bos taurus	ODAM	VGNC	VGNC:50115
Others	ODAM	NCBI