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MED1 - mediator complex subunit 1 Gene

Also Known as PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5469

About MED1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,404,285-39,451,263 (from NCBI)

This gene has 5 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in lymph node (RPKM 8.1), appendix (RPKM 7.7) and 25 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of Other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent Apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

MED1 Products (1)

mRNA	Protein	Name
NM_004774.4	NP_004765.2	mediator of RNA polymerase II transcription subunit 1

MED1 Protein Structure

Med1

0
300
600
900
1200
1500
1581 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 1	ARC205

MED1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MED1	Q15648	THRA	Homo sapiens	P10827	Anti Tag CoIP	9653119
Intra	MED1	Q15648	THRA	Homo sapiens	P10827	Pull Down	9653119
Intra	MED1	Q15648	VDR	Homo sapiens	P11473	Solution Sedimentation	21478865
Intra	MED1	Q15648	VDR	Homo sapiens	P11473	GMS	21478865
Intra	MED1	Q15648	VDR	Homo sapiens	P11473	Pull Down	12403843
Intra	MED1	Q15648	GATA1	Homo sapiens	P15976	Pull Down	17132730
Intra	MED1	Q15648	GATA1	Homo sapiens	P15976	Y2H	17132730
Intra	MED1	Q15648	MED7	Homo sapiens	O43513	Anti Tag CoIP	24882805
Intra	MED1	Q15648	MED7	Homo sapiens	O43513	Anti Tag CoIP	33961781
Intra	MED1	Q15648	MED21	Homo sapiens	Q13503	Anti Tag CoIP	24882805
Intra	MED1	Q15648	RARA	Homo sapiens	P10276	GMS	21478865
Intra	MED1	Q15648	RARA	Homo sapiens	P10276	SAXS	21478865
Intra	MED1	Q15648	RARA	Homo sapiens	P10276	Solution Sedimentation	21478865
Intra	MED1	Q15648	RARA	Homo sapiens	P10276	Y2H	17641689
Intra	MED1	Q15648	ESR1	Homo sapiens	P03372	Pull Down	9653119
Intra	MED1	Q15648	RXRA	Homo sapiens	P19793	Solution Sedimentation	21478865
Intra	MED1	Q15648	RXRA	Homo sapiens	P19793	GMS	21478865
Intra	MED1	Q15648	RXRA	Homo sapiens	P19793	SAXS	21478865

Cross: Cross-species interaction Intra: Intraspecies interaction

MED1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85872	MED1 Antibody (YA5564)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08184	MBD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08278	MED1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18247	Med1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19616	Mbd4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22462	Cwc15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24727	Med1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MED1	VGNC	VGNC:31346
Mus musculus	MED1	MGD	MGI:1100846
Macaca mulatta	MED1	VGNC	VGNC:74724
Felis catus	MED1	VGNC	VGNC:68975
Rattus norvegicus	MED1	RGD	RGD:1559552
Canis familiaris	MED1	VGNC	VGNC:43117
Others	MED1	NCBI