2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. RX-RA-69

RX-RA-69 is an orally active platelet phosphodiesterase (PDE) inhibitor with a IC50 of 1 nM. RX-RA-69 elevates cAMP levels in platelets, exerts anti-aggregatory effects, and inhibits the formation of coronary platelet thrombi. RX-RA-69 exhibits anti-metastatic activity in a mouse Lewis lung cancer model. RX-RA-69 can be used in research related to coronary platelet thrombi and Lewis lung cancer.

For research use only. We do not sell to patients.

RX-RA-69

RX-RA-69 Chemical Structure

CAS No. : 77749-49-6

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RX-RA-69 Related Antibodies

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Description

RX-RA-69 is an orally active platelet phosphodiesterase (PDE) inhibitor with a IC50 of 1 nM. RX-RA-69 elevates cAMP levels in platelets, exerts anti-aggregatory effects, and inhibits the formation of coronary platelet thrombi. RX-RA-69 exhibits anti-metastatic activity in a mouse Lewis lung cancer model. RX-RA-69 can be used in research related to coronary platelet thrombi and Lewis lung cancer[1][2].

In Vitro

RX-RA 69 inhibits tumor cell-induced platelet aggregation in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RX-RA-69 Related Antibodies
In Vivo

RX-RA 69 (60-120 μg/kg; intravenous injection; single bolus; 1.0-10.0 ng/kg/min; intracoronary; infusion; 30 min) dose-dependently inhibits coronary platelet thrombus formation in anesthetized dogs: intravenous bolus doses of 60 μg/kg and 120 μg/kg eliminate cyclic flow reduction for 8.7 min and 17.9 min, respectively; in contrast, intracoronary infusion exerts antithrombotic effects at lower doses with minimal cardiovascular impacts[1].
RX-RA 69 (1 mg/kg; p.o.) exhibits anti-metastatic activity in a mouse Lewis lung cancer model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mongrel dogs (either sex, weight 19.5-29.0 kg, modified Folts model)[1]
Dosage: 60 μg/kg (i.v. bolus); 120 μg/kg (i.v. bolus); 1.0 ng/kg/min (i.c. infusion); 3.0 ng/kg/min (i.c. infusion); 10.0 ng/kg/min (i.c. infusion)
Administration: i.v. (single bolus); i.c. (infusion, 30 min)
Result: Reduced the resistance of blood vessels throughout the body, resulting in a systemic decrease in blood pressure.
Increased myocardial contractility (increase the maximum ascending rate of left ventricular pressure).
Molecular Weight

423.53

Formula

C21H25N7OS
CAS No.
SMILES

C1(N=CN=C2SCC3=CC=CC=C3)=C2N=C(N4CCNCC4)N=C1N5CCOCC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RX-RA-69 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RX-RA-6977749-49-6Phosphodiesterase (PDE)platelet phosphodiesterasemouse Lewis lung carcinomaanaesthetized dogscyclic AMPplateletstumor cell-induced platelet aggregationcoronary platelet thrombiInhibitorinhibitorinhibit

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