1. Immunology/Inflammation
  2. Galectin
  3. Thiodigalactoside

Thiodigalactoside (Synonyms: TDG)

Cat. No.: HY-130208 Purity: ≥99.0%
Handling Instructions

Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.

For research use only. We do not sell to patients.

Thiodigalactoside Chemical Structure

Thiodigalactoside Chemical Structure

CAS No. : 51555-87-4

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Solution
10 mM * 1 mL in Water USD 215 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 215 In-stock
Estimated Time of Arrival: December 31
Solid
25 mg USD 195 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively[1]. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[2].

IC50 & Target

Kd: 24 μM (GAL1) and 49 μM (GAL3)[1]

In Vitro

Thiodigalactoside (TDG; 250 and 500 μM) exhibits dose-dependent reduction of fat accumulation based on triglyceride (TG) content and Oil Red O (ORO) staining[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain[2].
Thiodigalactoside (5 mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old Sprague-Dawley (SD) male rats[2]
Dosage: 5 mg/kg
Administration: IP; once per week for 5 weeks
Result: Resulted in dramatic inhibition of HFD-induced body weight gain by inhibiting adipogenesis and lipogensis as well as by increasing expression of the proteins associated with thermogenesis and energy expenditure.
Molecular Weight

358.36

Formula

C12H22O10S

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (279.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7905 mL 13.9525 mL 27.9049 mL
5 mM 0.5581 mL 2.7905 mL 5.5810 mL
10 mM 0.2790 mL 1.3952 mL 2.7905 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥99.0%

References
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Product Name:
Thiodigalactoside
Cat. No.:
HY-130208
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