Thiodigalactoside
Based on 5 publication(s) in Google Scholar
Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 51555-87-4
- Formula: C12H22O10S
- Molecular Weight:358.36
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Thiodigalactoside
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Others
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ELISA
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In Vivo Efficacy Study
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IF
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WB
All Galectin Isoforms
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Biological Activity
Kd: 24 μM (GAL1) and 49 μM (GAL3)[1]
Thiodigalactoside (TDG; 250 and 500 μM) exhibits dose-dependent reduction of fat accumulation based on triglyceride (TG) content and Oil Red O (ORO) staining[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Thiodigalactoside (5 mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Five-week-old Sprague-Dawley (SD) male rats[2]
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Dosage:5 mg/kg
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Administration:IP; once per week for 5 weeks
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Result:Resulted in dramatic inhibition of HFD-induced body weight gain by inhibiting adipogenesis and lipogensis as well as by increasing expression of the proteins associated with thermogenesis and energy expenditure.
Chemical Information
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CAS No. 51555-87-4
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Appearance Solid
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Molecular Weight 358.36
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Formula C12H22O10S
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Color White to off-white
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SMILES
O[C@H]([C@H]1O)[C@@H](O[C@@H]([C@@H]1O)CO)S[C@@H]([C@@H]([C@H]2O)O)O[C@@H]([C@@H]2O)CO
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Synonyms
TDG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Nanotechnol
Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape. [Abstract]2025 Aug 11:10.1038/s41565-025-01974-5. PMID: 40789922
Thiodigalactoside purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2025 Aug 11:10.1038/s41565-025-01974-5. [Abstract]
Thiodigalactoside (TG: 2.5 mg/mL) pre-treatment in RAW macrophages significantly reduces the number of galectin-9 puncta.
Thiodigalactoside purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2025 Aug 11:10.1038/s41565-025-01974-5. [Abstract]
In in vitro RAW 264.7 macrophages, Thiodigalactoside (TG) pre-treatment abrogates the LNP-induced upregulation of the pro-inflammatory cytokines IL-6, TNF-α, IL-1α and the chemokine MCP-1.
Thiodigalactoside purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2025 Aug 11:10.1038/s41565-025-01974-5. [Abstract]
When Thiodigalactoside (TG: 100 μg) and LNP were administered intravenously, TG pretreatment increased mRNA expression in the liver and spleen by approximately 2.7-fold and 2.4-fold, respectively.
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Osteoarthritis Cartilage
Galectin-8 involves in arthritic condylar bone loss via podoplanin/AKT/ERK axis-mediated inflammatory lymphangiogenesis. [Abstract]2023 Jun;31(6):753-765. PMID: 36702375
Thiodigalactoside purchased from MedChemExpress. Usage Cited in: Osteoarthritis Cartilage. 2023 Jun;31(6):753-765. [Abstract]
The co-localization and expression of Gal-8 and PDPN were detected by immunofluorescence staining. LECs were treated with or without TNFα±TDG (Thiodigalactoside) and stained with Gal-8 (green) and PDPN (red) antibodies.
Thiodigalactoside purchased from MedChemExpress. Usage Cited in: Osteoarthritis Cartilage. 2023 Jun;31(6):753-765. [Abstract]
LECs were treated with or without TNFα±TDG (Thiodigalactoside). The relative expression levels of total AKT, phosphorylated AKT, total ERK, phosphorylated ERK, Gal-8, phosphorylated IκBα, RelA, and RelB were determined by Western blotting.
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FEBS J
Gal-1 promotes lung cancer cell survival by enhancing PARP1/H1.2 interaction to promote DNA repair upon DNA damage response. [Abstract]2025 Dec;292(23):6211-6232. PMID: 40365664 -
iScience
Niche-expressed Galectin-1 is involved in pre-B acute lymphoblastic leukemia relapse through pre-B cell receptor activation. [Abstract]2023 Mar 11;26(4):106385. PMID: 37009219 -
bioRxiv
Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects. [Abstract]2024 Apr 18:2024.04.16.589801. PMID: 38659905
Solvent & Solubility
H2O : 100 mg/mL (279.05 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (279.05 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hilde van Hattum, et al. Tuning the Preference of Thiodigalactoside- And Lactosamine-Based Ligands to galectin-3 Over galectin-1. J Med Chem. 2013 Feb 14;56(3):1350-4. [Content Brief]
[2]. Varun V Prabhu, et al. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner. Cancer Res. 2015 Apr 1;75(7):1423-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.7905 mL | 13.9525 mL | 27.9049 mL | 69.7623 mL |
| 5 mM | 0.5581 mL | 2.7905 mL | 5.5810 mL | 13.9525 mL | |
| 10 mM | 0.2790 mL | 1.3952 mL | 2.7905 mL | 6.9762 mL | |
| 15 mM | 0.1860 mL | 0.9302 mL | 1.8603 mL | 4.6508 mL | |
| 20 mM | 0.1395 mL | 0.6976 mL | 1.3952 mL | 3.4881 mL | |
| 25 mM | 0.1116 mL | 0.5581 mL | 1.1162 mL | 2.7905 mL | |
| 30 mM | 0.0930 mL | 0.4651 mL | 0.9302 mL | 2.3254 mL | |
| 40 mM | 0.0698 mL | 0.3488 mL | 0.6976 mL | 1.7441 mL | |
| 50 mM | 0.0558 mL | 0.2790 mL | 0.5581 mL | 1.3952 mL | |
| 60 mM | 0.0465 mL | 0.2325 mL | 0.4651 mL | 1.1627 mL | |
| 80 mM | 0.0349 mL | 0.1744 mL | 0.3488 mL | 0.8720 mL | |
| 100 mM | 0.0279 mL | 0.1395 mL | 0.2790 mL | 0.6976 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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