2. Signaling Pathways
  3. Immunology/Inflammation
  4. Galectin
  5. Galectin-1 Isoform

Galectin-1

Galectin-1 is a β-galactoside-binding protein with intracellular and extracellular activity, and evidence identifies Galectin-1 and its ligands as regulators of T-cell homeostasis, survival, immune disorders, inflammation, allergies, and host-pathogen interactions[1]. Mechanistically, Galectin-1 regulates immune and inflammatory cells through carbohydrate-dependent binding and cross-linking of cell-surface glycoproteins, including CD2, CD3, CD7, CD43, and CD45 on T cells[1]. In disease models, Galectin-1 inhibited microglial activation and ameliorated neurodegeneration in a Parkinson’s disease model through the MAPK/IκB/NFκB axis and its carbohydrate-recognition domain[2]. In collagen-induced arthritis, absence of endogenous Galectin-1 increased susceptibility and disease severity, supporting its inhibitory role in experimental inflammation[3]. Compared with related isoforms, Galectin-1 and Galectin-3 bind distinct T-cell surface glycoprotein receptors, while Galectin-9 and Galectin-1 require different glycan ligands and glycoprotein receptors to trigger T-cell death[4][5]. For experimental oncology applications, Galectin-1 overexpression was detected in hepatocellular carcinoma, and OTX008 combined with sorafenib significantly reduced tumor growth and size in tumor-cell models[6].

Galectin-1 Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-19756
    OTX008
    		Inhibitor 99.94%
    OTX008 is a selective inhibitor of galectin-1.
  • HY-162561
    GB1908
    		Inhibitor 98.94%
    GB1908 is a selective and orally active galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively. GB1908 displays >50-fold selectivity over galectin-3. GB1908 can be used for the study of lung cancer.
  • HY-163082
    GB1490
    		Inhibitor 98.48%
    GB1490 is an orally active galectin inhibitor with Kd values of 0.4 μM and 2.7 μM for galectin-1 and galectin-3, respectively.
  • HY-157821
    Galectin-4-IN-3
    		Inhibitor
    Galectin-4-IN-3 (Compound 11) is a Galectin 4C inhibitor, with a Kd of 160 μM.
  • HY-181648
    Gal-1-IN-1
    		Inhibitor
    Gal-1-IN-1 is a potent and selective human galectin-1 (hGal-1) inhibitor with a Ki of 0.022 μM. Gal-1-IN-1 blocks hGal-1 binding to tumor cells and suppresses human galectin-1-induced pre-apoptosis state. Gal-1-IN-1 reduces hGal-1-expressing cancer cell viability. Gal-1-IN-1 can be used for the research of breast cancer.
  • HY-183582
    GB1841
    		Inhibitor
    GB1841 is an orally active and selective galectin inhibitor with human galectin-1 Kd of 0.027 μM, human galectin-3 Kd of 0.14 μM, mouse galectin-1 Kd of 0.034 μM and mouse galectin-3 Kd of 1.170 μM. GB1841 can be used for the research of lung cancer.
  • HY-147865
    Apoptosis inducer 8
    		Inhibitor
    Apoptosis inducer 8 (Compound 7c) is a galectin-1 (gal-1) mediated apoptosis-inducing agent against global major leading lung cancer burden. Apoptosis inducer 8 significantly reduced the gal-1 protein level. Apoptosis inducer 8 is also a PET imaging agent.
  • HY-163407
    Galectin-3-IN-4
    		Inhibitor
    Galectin-3-IN-4 (compound 5) is a carboxamide analog. Galectin-3-IN-4 is a potent, selective, and orally bioavailable inhibitor of human and mouse galectin-3, with IC50 values of 21 and 167 nM for hGal-3 and mGal-3, respectively. Galectin-3-IN-4 has IC50 values of 1580 and 2750 nM for hGal-1 and hGal-9, respectively.
Cat. No. Product Name / Synonyms Application Reactivity