2. Immunology/Inflammation Apoptosis
  3. Galectin Apoptosis
  4. Gal-1-IN-1

Gal-1-IN-1 is a potent and selective human galectin-1 (hGal-1) inhibitor with a Ki of 0.022 μM. Gal-1-IN-1 blocks hGal-1 binding to tumor cells and suppresses human galectin-1-induced pre-apoptosis state. Gal-1-IN-1 reduces hGal-1-expressing cancer cell viability. Gal-1-IN-1 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

Gal-1-IN-1

Gal-1-IN-1 Chemical Structure

CAS No. : 3059548-99-8

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Gal-1-IN-1 Related Antibodies

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Description

Gal-1-IN-1 is a potent and selective human galectin-1 (hGal-1) inhibitor with a Ki of 0.022 μM. Gal-1-IN-1 blocks hGal-1 binding to tumor cells and suppresses human galectin-1-induced pre-apoptosis state. Gal-1-IN-1 reduces hGal-1-expressing cancer cell viability. Gal-1-IN-1 can be used for the research of breast cancer[1].

IC50 & Target[1]

Galectin-1

0.022 μM (Ki)

Galectin-3

22 μM (Ki)

Galectin-1

0.0005 μM (Kd)

Galectin-3

9 μM (Kd)

In Vitro

Gal-1-IN-1 (Compound 15-PF) potently inhibits human galectin-1 with a Ki of 0.022 μM and shows 950-fold selectivity over human galectin-3-CRD (Ki = 22 μM)[1].
Gal-1-IN-1 binds human galectin-1 with a Kd of 0.0005 ± 0.0002 μM and shows 18,000-fold selectivity over human galectin-3-CRD (KD = 9 μM)[1].
Gal-1-IN-1 inhibits human galectin-1 binding to MDA-MB-231 breast cancer cells with an IC50 of 64 ± 26 pM[1].
Gal-1-IN-1 (15-PF) (10-20 μM; 1 h) fully suppresses human galectin-1-induced preaparesis in Jurkat T cells at both 10 μM and 20 μM[1].
Gal-1-IN-1 (0.05-100 μM; 72 h) reduces viability of hGal-1-expressing MDA-MB-231 breast cancer cells by up to 50% at 25-100 μM, with negligible cytotoxicity against hGal-1-negative HEK-293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gal-1-IN-1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-231 human breast cancer cells, HEK-293 noncancerous human embryonic kidney cells
Concentration: 0.05, 0.2, 1, 2.5, 5, 10, 25, 100 μM
Incubation Time: 72 h
Result: Reduced MDA-MB-231 cell viability.
Had negligible cytotoxicity against HEK-293 cells.
Molecular Weight

1446.03

Formula

C46H59Cl2F12N8O8P2Ru2S
CAS No.
SMILES

[P+5]([F-])([F-])([F-])([F-])([F-])[F-].[Cl-][Ru+2]123456(C=7(C(C)C)[CH]1=[CH]2C3(C)=[CH]4[CH]57)[N]=8C(C=9[N]6=CC=CC9)=CN(N8)[C@@H]%10[C@@H](O)[C@H](S[C@]%11([C@H](O)[C@H]([C@@H](O)[C@@H](CO)O%11)N%12N=[N]%13C(=C%12)C=%14[N]([Ru+2]%13%15%16%17%18%19([Cl-])C=%20(C(C)C)[CH]%15=[CH]%16C%17(C)=[CH]%18[CH]%19%20)=CC=CC%14)[H])O[C@H](CO)[C@@H]%10O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Gal-1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gal-1-IN-13059548-99-8GalectinApoptosisHEK-293 cellshuman galectin-3-CRDhuman galectin-3breast cancerphosphatidylserinehuman galectin-1Jurkat T cellsglycan ligandsMDA-MB-231 tumor cell surfacesInhibitorinhibitorinhibit

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