1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. HB007

HB007 

Cat. No.: HY-139662
Handling Instructions

HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers.

For research use only. We do not sell to patients.

HB007 Chemical Structure

HB007 Chemical Structure

CAS No. : 2387821-46-5

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Description

HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers[1][2].

IC50 & Target

SUMO1[1]

In Vitro

HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1].
HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

328.78

Formula

C₁₅H₉ClN₄OS

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HB007
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