2387821-46-5
Chemical Structure
HB007
- CAS No.: 2387821-46-5
- Formula:C15H9ClN4OS
- Molecular Weight:328.78
IUPAC Name: 1-(3-chlorophenyl)-3-(6-cyanobenzo[d]thiazol-2-yl)urea
InChIKey: URCZUKFRZQNQSQ-UHFFFAOYSA-N
SMILES: N#CC1=CC2=C(N=C(NC(NC3=CC(Cl)=CC=C3)=O)S2)C=C1
Biological Activity: HB007 is a SUMO1 molecular glue degrader targeting CAPRIN1 and FBXO42. HB007 selectively binds CAPRIN1 to induce CAPRIN1-FBXO42 interaction, recruits SUMO1 to the CAPRIN1-CUL1-FBXO42 E3 ligase complex, and drives SUMO1 ubiquitination and degradation without affecting SUMO2/3. HB007 induces TCF4 deSUMOylation and proteasomal degradation to inhibit StarD7 transcriptional activity, reduces StarD7 mRNA and protein levels, and triggers ER stress and ROS production. HB007 can be used for the research of brain cancer, breast cancer, colon cancer, lung cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HB007 | 99.73% | HB007 is a SUMO1 molecular glue degrader targeting CAPRIN1 and FBXO42. HB007 selectively binds CAPRIN1 to induce CAPRIN1-FBXO42 interaction, recruits SUMO1 to the CAPRIN1-CUL1-FBXO42 E3 ligase complex, and drives SUMO1 ubiquitination and degradation without affecting SUMO2/3. HB007 induces TCF4 deSUMOylation and proteasomal degradation to inhibit StarD7 transcriptional activity, reduces StarD7 mRNA and protein levels, and triggers ER stress and ROS production. HB007 can be used for the research of brain cancer, breast cancer, colon cancer, lung cancer. | ||||||||||||||||||||
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References
- [1]. Zhao YQ, et al. SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer. Molecular carcinogenesis. 2023 Sep;62(9):1249-1262.
- [2]. Dougherty, Carson, et al. HB007 Administration Inhibits LN-229 and Patient-Derived Neurospheroid Glioblastoma Cell Growth With the Degradation of SUMO1 and Cell Cycle Regulator CDK4.
- [3]. Bellail AC, et al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Science translational medicine. 2021 Oct 13;13(615):eabh1486. [Content Brief]
