EIF4E - eukaryotic translation initiation factor 4E Gene

Also Known as CBP; EIF4F; AUTS19; EIF4E1; eIF-4E; EIF4EL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1977

About EIF4E

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:98,879,276-98,929,133 (from NCBI)

This gene has 11 transcripts (splice variants), 329 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 13.1), thyroid (RPKM 12.0) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on Other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

EIF4E Products (4)

mRNA	Protein	Name
NM_001130678.4	NP_001124150.1	eukaryotic translation initiation factor 4E isoform 3
NM_001130679.3	NP_001124151.1	eukaryotic translation initiation factor 4E isoform 2
NM_001331017.2	NP_001317946.1	eukaryotic translation initiation factor 4E isoform 4
NM_001968.5	NP_001959.1	eukaryotic translation initiation factor 4E isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	23814182	GOA
enables RNA 7-methylguanosine cap binding	IDA IDA: Inferred from direct assay	19750007	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	23814182	GOA
enables eukaryotic initiation factor 4G binding	IDA IDA: Inferred from direct assay	18337562	GOA
enables mRNA cap binding	IDA IDA: Inferred from direct assay	16271312	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7651417	GOA
enables translation initiation factor activity	IDA IDA: Inferred from direct assay	22578813	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	14673156	GOA
NOT involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	14673156	GOA
involved in regulation of translation	IDA IDA: Inferred from direct assay	22578813	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	16157702	GOA
part of RISC complex	IDA IDA: Inferred from direct assay	20616046	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	1384058	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	21883093	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19750007	GOA
part of eukaryotic translation initiation factor 4F complex	IDA IDA: Inferred from direct assay	22578813	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	10648556	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1384058	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	23814182	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4E Protein Structure

IF4E

0
100
200
237 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 4E	eIF-4F 25 kDa subunit

EIF4E Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF4E	P06730	LRPPRC	Homo sapiens	P42704	Anti Bait CoIP	19262567
Intra	EIF4E	P06730	LRPPRC	Homo sapiens	P42704	Anti Tag CoIP	19262567
Intra	EIF4E	P06730	EIF4G3	Homo sapiens	O43432-1	Pull Down	21191102
Intra	EIF4E	P06730	EIF4G3	Homo sapiens	O43432-1	NMR	20212144
Cross	EIF4E	P06730	Btg4	Mus musculus	O70552	Anti Tag CoIP	27065194
Intra	EIF4E	P06730	KANK2	Homo sapiens	Q63ZY3	Y2H Array	24722188
Intra	EIF4E	P06730	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	EIF4E	P06730	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	EIF4E	P06730	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	25416956
Intra	EIF4E	P06730	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	EIF4E	P06730	EIF4ENIF1	Homo sapiens	Q9NRA8	TAP	24981860
Intra	EIF4E	P06730	EIF4ENIF1	Homo sapiens	Q9NRA8	Anti Tag CoIP	33961781
Intra	EIF4E	P06730	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Prey Pooling	25416956
Intra	EIF4E	P06730	EIF4ENIF1	Homo sapiens	Q9NRA8	CoIP	10856257
Intra	EIF4E	P06730	EIF4ENIF1	Homo sapiens	Q9NRA8	Imaging	16467844
Intra	EIF4E	P06730	EIF4ENIF1	Homo sapiens	Q9NRA8	Anti Tag CoIP	28514442
Intra	EIF4E	P06730	EMX2	Homo sapiens	Q04743	Pull Down	15247416
Intra	EIF4E	P06730	EMX2	Homo sapiens	Q04743	Affinity Chrom	15247416
Intra	EIF4E	P06730	EMX2	Homo sapiens	Q04743	CoIP	15247416
Intra	EIF4E	P06730	PPP2CA	Homo sapiens	P67775	Anti Bait CoIP	20927323
Intra	EIF4E	P06730	PPP2CA	Homo sapiens	P67775	Phosphatase Assay	20927323
Intra	EIF4E	P06730	TRIM27	Homo sapiens	P14373	Y2H Array	24722188
Intra	EIF4E	P06730	TRIM27	Homo sapiens	P14373	Y2H Array	31515488
Intra	EIF4E	P06730	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	EIF4E	P06730	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	EIF4E	P06730	EIF4G1	Homo sapiens	Q04637	Anti Tag CoIP	33961781
Intra	EIF4E	P06730	EIF4G1	Homo sapiens	Q04637	Pull Down	20212144
Intra	EIF4E	P06730	EIF4G1	Homo sapiens	Q04637	Anti Bait CoIP	18955708
Intra	EIF4E	P06730	EIF4G1	Homo sapiens	Q04637	Anti Bait CoIP	23665581
Intra	EIF4E	P06730	EIF4G1	Homo sapiens	Q04637	Pull Down	15153109
Intra	EIF4E	P06730	EIF4G1	Homo sapiens	Q04637	TAP	24981860
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Far-WB	7651417
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Validated Y2H	32296183
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	TAP	24981860
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Y2H Prey Pooling	32296183
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Y2H Array	32296183
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Anti Tag CoIP	28514442
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Anti Tag CoIP	20224576
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	SPR	10772338
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Anti Tag CoIP	33961781
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Pull Down	21191102
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Y2H Pooling	16189514
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Pull Down	18955708
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Far-WB	15153109
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Y2H Array	24722188
Intra	EIF4E	P06730	EIF4EBP1	Homo sapiens	Q13541	Anti Bait CoIP	19834456
Intra	EIF4E	P06730	TDO2	Homo sapiens	P48775	Y2H Array	25416956
Intra	EIF4E	P06730	TDO2	Homo sapiens	P48775	Y2H Array	24722188
Intra	EIF4E	P06730	UBXN11	Homo sapiens	Q5T124	Y2H Prey Pooling	25416956
Intra	EIF4E	P06730	EIF4EBP3	Homo sapiens	O60516	Y2H Prey Pooling	32296183
Intra	EIF4E	P06730	EIF4EBP3	Homo sapiens	O60516	Y2H Array	32296183
Intra	EIF4E	P06730	EIF4EBP3	Homo sapiens	O60516	CoIP	9593750
Intra	EIF4E	P06730	EIF4EBP3	Homo sapiens	O60516	Y2H Array	24722188
Intra	EIF4E	P06730	SUMO1	Homo sapiens	P63165	Anti Bait CoIP	20224576
Intra	EIF4E	P06730	PABPC1	Homo sapiens	P11940	Anti Bait CoIP	23665581
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	Anti Tag CoIP	33961781
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	Y2H Prey Pooling	32296183
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	Filter Binding	7935836
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	Y2H Array	31515488
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	Y2H Array	24722188
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	Far-WB	15153109
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	Validated Y2H	32296183
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	Y2H Array	25416956
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	TAP	24981860
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	Y2H Array	32296183
Intra	EIF4E	P06730	EIF4EBP2	Homo sapiens	Q13542	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF4E Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70152	EIF4E Protein, Human	AAH12611.1 (M1-V217)	≥ 85%, as determined by reducing SDS-PAGE.

EIF4E Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80118	eIF4E Antibody (YA463)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P80812	Phospho-eIF4E (Ser209) Antibody (YA202)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P80812A	Phospho-eIF4E (Ser209) Antibody (YA202)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P85133	eIF4E Antibody (YA4825)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P86175	eIF4E Antibody (YA5867)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Autism 19	Autism, Susceptibility To, 19 AUTS19 Autism, Susceptibility To, Type 19
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Bronchiolo-Alveolar Adenocarcinoma	Bronchioloalveolar Carcinoma Bronchioalveolar Lung Carcinoma Minimally Invasive Lung Adenocarcinoma Carcinoma Bronchioloalveolar Adenocarcinoma, Bronchiolo-Alveolar Bronchioloalveolar Adenocarcinoma
Kidney Cancer	Renal Cancer Renal Carcinoma Kidney Neoplasm Malignant Neoplasm Of Kidney Except Pelvis Malignant Tumour Of Kidney Kidney Neoplasms Cancer, Kidney Cancer, Renal Malignant Neoplasm Of Kidney Renal Cell Carcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Vallecula Cancer	Malignant Tumor Of Vallecula
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Combined Oxidative Phosphorylation Deficiency 33	COXPD33
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100022	Tomivosertib	Inhibitor	99.92%	Phase 2
HY-16366	Briciclib		99.45%	Phase 1

Pre-clinical Phase

Bioactive Molecules (42)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19831	4EGI-1		98.69%	Unkown
HY-145974A	m7GpppAmpG ammonium solution (100 mM)		99.96%	Unkown
HY-14427	4E1RCat	Inhibitor	99.04%	Unkown
HY-159059	Ganoderma Lucidum/Reishi Extract		41.20%	Unkown
HY-145262	eIF4E-IN-2	Inhibitor	98.91%	Unkown
HY-145969A	β-S-ARCA triammonium		99.48%	Unkown
HY-100733	4E2RCat	Inhibitor	98.0%	Unkown
HY-119271	CMLD010509		99.11%	Unkown
HY-19831A	(Z)-4EGI-1	Inhibitor	98.0%	Unkown
HY-176428	PROTAC MNK1 degrader-1		98.93%	Unkown
HY-146805	EB1		99.91%	Unkown
HY-RS04274	EIF4E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-114267	Cbz-B3A	Inhibitor	98.63%	Unkown
HY-148105	DS12881479		99.63%	Unkown
HY-145309	eIF4E-IN-3	Inhibitor	/	Unkown
HY-145969	β-S-ARCA		/	Unkown
HY-139098A	7-Methyl-diguanosine triphosphate ammonium solution (100 mM)		98.83%	Unkown
HY-178672A	ARCA triammonium solution (100 mM)		/	Unkown
HY-100022A	Tomivosertib hydrochloride	Inhibitor	/	Unkown
HY-145240	eIF4E-IN-1	Inhibitor	/	Unkown
HY-145974AGL	m7GpppAmpG ammonium solution (100 mM) (GMP like)		/	Unkown
HY-148664	eIF4E-IN-4	Inhibitor	/	Unkown
HY-155337	eIF4E-IN-6	Inhibitor	/	Unkown
HY-155676	eIF4E-IN-5	Inhibitor	/	Unkown
HY-163479	MNK1/2-IN-7	Inhibitor	/	Unkown
HY-16366A	Briciclib sodium		/	Unkown
HY-176288	eIF4E/eIF4G PPI-IN-1		/	Unkown
HY-182046	HD202A		/	Unkown
HY-182939	MNK1/2-IN-10	Inhibitor	/	Unkown
HY-182957	MNK/PIM-IN-2		/	Unkown
HY-184004	NUCC-0231068	Inhibitor	/	Unkown
HY-RS04275	EIF4E2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04276	EIF4E3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W846144	ETP-45835	Inhibitor	/	Unkown
HY-119271A	(-)-CMLD010509		/	Unkown
HY-139098	7-Methyl-diguanosine triphosphate		/	Unkown
HY-145974	m7GpppAmpG		/	Unkown
HY-168326	Antiproliferative agent-64	Inhibitor	/	Unkown
HY-172457	NUCC-0200808	Inhibitor	/	Unkown
HY-182704	SBI-5844	Inhibitor	/	Unkown
HY-RS17829	Eif4e Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24297	Eif4e Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EIF4E	VGNC	VGNC:100221
Canis familiaris	EIF4E	VGNC	VGNC:40283
Bos taurus	EIF4E	VGNC	VGNC:28408
Mus musculus	EIF4E	MGD	MGI:95305
Rattus norvegicus	EIF4E	RGD	RGD:69647
Felis catus	EIF4E	VGNC	VGNC:78484
Others	EIF4E	NCBI