eIF4E-IN-2
Based on 1 Customer Validation
eIF4E-IN-2 is a potent inhibitor of eukaryotic initiation factor 4e (eIF4e) with an IC50 of 13 nM. eIF4E-IN-2 inhibits MDA-MB-361 cells proliferation. eIF4E-IN-2 can be used for the study of breast cancer.
For research use only. We do not sell to patients.
- Purity: 98.91%
- CAS No.: 2575840-38-7
- Formula: C37H33ClF2N8O4S2
- Molecular Weight:791.29
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
eIF4 13 nM () |
eIF4E-IN-2 (Compound 1188) inhibits MDA-MB-361 cells proliferation with an IC50 of 46.8 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2575840-38-7
-
Appearance Solid
-
Molecular Weight 791.29
-
Formula C37H33ClF2N8O4S2
-
Color Light yellow to yellow
-
SMILES
N#CC1=C(N(C2CCN(C3CC(F)(C3)F)CC2)C)N=CC(N=C(C)N4CC#CC5=CC=C(C=C5C6=CC=NC7=C6SC=C7C(NS(=O)(C)=O)=O)Cl)=C1C4=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (63.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2638 mL | 6.3188 mL | 12.6376 mL | 31.5940 mL |
| 5 mM | 0.2528 mL | 1.2638 mL | 2.5275 mL | 6.3188 mL | |
| 10 mM | 0.1264 mL | 0.6319 mL | 1.2638 mL | 3.1594 mL | |
| 15 mM | 0.0843 mL | 0.4213 mL | 0.8425 mL | 2.1063 mL | |
| 20 mM | 0.0632 mL | 0.3159 mL | 0.6319 mL | 1.5797 mL | |
| 25 mM | 0.0506 mL | 0.2528 mL | 0.5055 mL | 1.2638 mL | |
| 30 mM | 0.0421 mL | 0.2106 mL | 0.4213 mL | 1.0531 mL | |
| 40 mM | 0.0316 mL | 0.1580 mL | 0.3159 mL | 0.7898 mL | |
| 50 mM | 0.0253 mL | 0.1264 mL | 0.2528 mL | 0.6319 mL | |
| 60 mM | 0.0211 mL | 0.1053 mL | 0.2106 mL | 0.5266 mL |
Powered by Bioz