2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF)
  4. m7GpppAmpG ammonium solution (100 mM) (GMP like)

m7GpppAmpG ammonium solution (100 mM) (GMP like)  (Synonyms: m7G(5')ppp(5')(2'OMeA)pG solution (100 mM) (GMP like))

Cat. No.: HY-145974AGL
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m7GpppAmpG ammonium solution (100 mM) (GMP-like) (m7G(5')ppp(5')(2'OMeA)pG solution (100 mM) (GMP-like)) is a GMP-like grade of m7GpppAmpG ammonium. m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research.

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m7GpppAmpG ammonium solution (100 mM) (GMP like)

m7GpppAmpG ammonium solution (100 mM) (GMP like) Chemical Structure

CAS No. : 3080642-79-8

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m7GpppAmpG ammonium solution (100 mM) (GMP like) Related Antibodies

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Description

m7GpppAmpG ammonium solution (100 mM) (GMP-like) (m7G(5')ppp(5')(2'OMeA)pG solution (100 mM) (GMP-like)) is a GMP-like grade of m7GpppAmpG ammonium. m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research[1][2][3].

In Vitro

m7GpppAmpG ammonium enables efficient capping of RNA with 90% efficiency[1].
m7GpppAmpG ammonium binds eIF4E with a KD value of 45.6 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m7GpppAmpG ammonium solution (100 mM) (GMP like) Related Antibodies
In Vivo

m7GpppAmpG (10 μg mRNA per mouse; intramuscular injection) ammonium demonstrates lower translational efficiency and IgG antibody levels compared to novel cap analogs YK-CAP-02~04 in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1145.66 (free base)

Formula

C32H43N15O24P4·xNH3
CAS No.
SMILES

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](OC)[C@@H]4OP(OC[C@H]7O[C@@H](N(C=N8)C9=C8C(NC(N)=N9)=O)[C@H](O)[C@@H]7O)(O)=O)(O)=O)(O)=O)([O-])=O)O3)C=[N+]2C)N=C(N)N1.[x].N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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m7GpppAmpG ammonium solution (100 mM) (GMP like) Related Classifications

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Keywords:

m7GpppAmpG ammonium solution (100 mM) (GMP like)3080642-79-8m7G(5')ppp(5')(2'OMeA)pG solution (100 mM) (GMP like)DNA/RNA SynthesisEukaryotic Initiation Factor (eIF)capRNAmRNAInhibitorinhibitorinhibit

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