m7GpppAmpG ammonium solution (100 mM) (GMP like)
m7GpppAmpG ammonium solution (100 mM) (GMP-like) (m7G(5')ppp(5')(2'OMeA)pG solution (100 mM) (GMP-like)) is a GMP-like grade of m7GpppAmpG ammonium. m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research.
For research use only. We do not sell to patients.
- CAS No.: 3080642-79-8
- Formula: C32H43N15O24P4·xNH3
- Molecular Weight:1145.66 (free base)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3080642-79-8
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Molecular Weight 1145.66 (free base)
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Formula C32H43N15O24P4·xNH3
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SMILES
O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](OC)[C@@H]4OP(OC[C@H]7O[C@@H](N(C=N8)C9=C8C(NC(N)=N9)=O)[C@H](O)[C@@H]7O)(O)=O)(O)=O)(O)=O)([O-])=O)O3)C=[N+]2C)N=C(N)N1.[x].N
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Synonyms
m7G(5')ppp(5')(2'OMeA)pG solution (100 mM) (GMP like)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sikorski PJ, Warminski M, Kubacka D, et al. The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells. Nucleic Acids Res. 2020;48(4):1607-1626. [Content Brief]
[3]. Raab M, et al. Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer. Cancer Commun (Lond). 2024 Jan;44(1):101-126. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
m7GpppAmpG ammonium solution (100 mM) (GMP like) Related Classifications
HY-145974AGL Related Classifications
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