m7GpppAmpG ammonium solution (100 mM)
Based on 1 Customer Validation
m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research.
The product specifications provided below indicate the total amount only; they do not represent the actual content of m7GpppAmpG ammonium.
For research use only. We do not sell to patients.
- Purity : 99.96%
- CAS No.: 3080642-79-8
- Formula: C32H43N15O24P4·xNH3
- Molecular Weight:1145.67 (free base)
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
The product specifications provided below indicate the total amount only; they do not represent the actual content of m7GpppAmpG ammonium.
IC50 & Target
[1]|
eIF4E 45.6 nM (Kd) |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3080642-79-8
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Appearance Liquid
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Molecular Weight 1145.67 (free base)
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Formula C32H43N15O24P4·xNH3
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Color Colorless to light yellow
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SMILES
O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](OC)[C@@H]4OP(OC[C@H]7O[C@@H](N(C=N8)C9=C8C(NC(N)=N9)=O)[C@H](O)[C@@H]7O)(O)=O)(O)=O)(O)=O)([O-])=O)O3)C=[N+]2C)N=C(N)N1.[x].N
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Synonyms
m7G(5')ppp(5')(2'OMeA)pG ammonium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (286 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sikorski PJ, Warminski M, Kubacka D, et al. The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells. Nucleic Acids Res. 2020;48(4):1607-1626. [Content Brief]
[3]. Raab M, et al. Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer. Cancer Commun (Lond). 2024 Jan;44(1):101-126. [Content Brief]
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