UBXN11 - UBX domain protein 11 Gene

Also Known as SOC; SOCI; COA-1; UBXD5; PP2243

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91544

About UBXN11

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,282,282-26,318,355 (from NCBI)

This gene has 16 transcripts (splice variants), 187 orthologues and 3 paralogues. Broad expression in testis (RPKM 18.9), spleen (RPKM 17.6) and 25 other tissues.

Summary

This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UBXN11 Products (5)

mRNA Protein Name
NM_001077262.2 NP_001070730.1 UBX domain-containing protein 11 isoform 3
NM_001389556.1 NP_001376485.1 UBX domain-containing protein 11 isoform 2
NM_001389559.1 NP_001376488.1 UBX domain-containing protein 11 isoform 1
NM_145345.3 NP_663320.2 UBX domain-containing protein 11 isoform 1
NM_183008.3 NP_892120.2 UBX domain-containing protein 11 isoform 2

UBXN11 Protein Structure

SEP

SEP: SEP domain (235 - 306)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

UBX domain-containing protein 11

  • UBX domain-containing protein 5

UBXN11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBXN11 Q5T124 PRKAB2 Homo sapiens O43741
Validated Y2H
25416956
Intra
UBXN11 Q5T124 PRKAA1 Homo sapiens Q13131
Y2H Array
25416956
Intra
UBXN11 Q5T124 PRKAA1 Homo sapiens Q13131
Y2H Prey Pooling
25416956
Intra
UBXN11 Q5T124 RHOBTB3 Homo sapiens O94955
Y2H Array
31515488
Intra
UBXN11 Q5T124 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
UBXN11 Q5T124 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra
UBXN11 Q5T124 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra
UBXN11 Q5T124 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
25416956
Intra
UBXN11 Q5T124 PSMA1 Homo sapiens P25786
Y2H Array
25416956
Intra
UBXN11 Q5T124 EIF4E2 Homo sapiens O60573
Validated Y2H
25416956
Intra
UBXN11 Q5T124 EIF4E2 Homo sapiens O60573
Y2H Prey Pooling
25416956
Intra
UBXN11 Q5T124 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
UBXN11 Q5T124 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
UBXN11 Q5T124 EIF4E Homo sapiens P06730
Validated Y2H
25416956
Intra
UBXN11 Q5T124 EIF4E Homo sapiens P06730
Y2H Array
25416956
Intra
UBXN11 Q5T124 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra
UBXN11 Q5T124 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra
UBXN11 Q5T124 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra
UBXN11 Q5T124 ENKD1 Homo sapiens Q9H0I2
Y2H Prey Pooling
25416956
Intra
UBXN11 Q5T124 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
25416956
Intra
UBXN11 Q5T124 SH2D4A Homo sapiens Q9H788
Y2H Array
25416956
Intra
UBXN11 Q5T124 SH2D4A Homo sapiens Q9H788
Y2H Prey Pooling
25416956
Intra
UBXN11 Q5T124 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
Intra
UBXN11 Q5T124 SCNM1 Homo sapiens Q9BWG6
Y2H Prey Pooling
25416956
Intra
UBXN11 Q5T124 SCNM1 Homo sapiens Q9BWG6
Y2H Array
31515488
Intra
UBXN11 Q5T124 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
25416956
Intra
UBXN11 Q5T124 CFAP206 Homo sapiens Q8IYR0
Validated Y2H
25416956
Intra
UBXN11 Q5T124 CFAP206 Homo sapiens Q8IYR0
Y2H Pooling
16189514
Intra
UBXN11 Q5T124 CFAP206 Homo sapiens Q8IYR0
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Thyroid Hurthle Cell Adenoma

  • Benign Oncocytoma Of The Thyroid

  • Thyroid Gland Oncocytic Adenoma
Peroxisome Biogenesis Disorder 2a

  • PBD2A

  • Peroxisome Biogenesis Disorder Complementation Group 2

  • PBD-CG2

  • Cg1

  • Pbd-Cge

  • Peroxisome Biogenesis Disorder Complementation Group E

  • Peroxisome Biogenesis Disorder, Type 2a
Colon Carcinoma In Situ

  • Carcinoma In Situ Of Colon

  • Stage 0 Colonic Carcinoma

  • Stage 0 Carcinoma Of Colon

  • Intraepithelial Neoplasia Of Colon, High Grade

  • Carcinoma In Situ Of Cecum

  • Carcinoma In Situ Of Hepatic Flexure

  • Carcinoma In Situ Of Ileocecal Valve

  • Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15395 UBXN11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus UBXN11 VGNC VGNC:80399
Rattus norvegicus UBXN11 RGD RGD:620769
Bos taurus UBXN11 VGNC VGNC:36624
Mus musculus UBXN11 MGD MGI:1914836
Macaca mulatta UBXN11 VGNC VGNC:79859
Canis familiaris UBXN11 VGNC VGNC:48097
Others UBXN11 NCBI