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RHOBTB3 - Rho related BTB domain containing 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22836

About RHOBTB3

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:95,717,624-95,796,361 (from NCBI)

This gene has 16 transcripts (splice variants), 120 orthologues and 22 paralogues. Ubiquitous expression in fat (RPKM 37.7), ovary (RPKM 32.7) and 24 other tissues.

Summary

RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM, Apr 2004]

RHOBTB3 Products (1)

mRNA	Protein	Name
NM_014899.4	NP_055714.3	rho-related BTB domain-containing protein 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	19490898	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	19490898	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19490898	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	19490898	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	19490898	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOBTB3 Protein Structure

Ras

BTB

0
100
200
300
400
500
611 a.a.

Protein Preferred Names	Protein Names
rho-related BTB domain-containing protein 3

RHOBTB3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RHOBTB3	O94955	TBX15	Homo sapiens	Q96SF7	Y2H Prey Pooling	32296183
Intra	RHOBTB3	O94955	TBX15	Homo sapiens	Q96SF7	Validated Y2H	32296183
Intra	RHOBTB3	O94955	TBX15	Homo sapiens	Q96SF7	Y2H Array	32296183
Intra	RHOBTB3	O94955	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	RHOBTB3	O94955	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	RHOBTB3	O94955	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	RHOBTB3	O94955	USP54	Homo sapiens	Q70EL1-9	Validated Y2H	32296183
Intra	RHOBTB3	O94955	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	RHOBTB3	O94955	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	RHOBTB3	O94955	L3MBTL3	Homo sapiens	Q96JM7-2	Validated Y2H	32296183
Intra	RHOBTB3	O94955	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Array	32296183
Intra	RHOBTB3	O94955	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Prey Pooling	32296183
Intra	RHOBTB3	O94955	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	RHOBTB3	O94955	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	RHOBTB3	O94955	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	RHOBTB3	O94955	PLAGL2	Homo sapiens	Q9UPG8	Y2H Prey Pooling	32296183
Intra	RHOBTB3	O94955	PLAGL2	Homo sapiens	Q9UPG8	Validated Y2H	32296183
Intra	RHOBTB3	O94955	PLAGL2	Homo sapiens	Q9UPG8	Y2H Array	32296183
Intra	RHOBTB3	O94955	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	RHOBTB3	O94955	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	RHOBTB3	O94955	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	RHOBTB3	O94955	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	25416956
Intra	RHOBTB3	O94955	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	32296183
Intra	RHOBTB3	O94955	BHLHE40	Homo sapiens	O14503	Y2H Array	32296183
Intra	RHOBTB3	O94955	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	RHOBTB3	O94955	RBPMS	Homo sapiens	Q93062	Y2H Prey Pooling	25416956
Intra	RHOBTB3	O94955	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	RHOBTB3	O94955	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	RHOBTB3	O94955	UBXN11	Homo sapiens	Q5T124	Y2H Prey Pooling	25416956
Intra	RHOBTB3	O94955	UBXN11	Homo sapiens	Q5T124	Validated Y2H	25416956
Intra	RHOBTB3	O94955	UBXN11	Homo sapiens	Q5T124	Y2H Array	25416956
Intra	RHOBTB3	O94955	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	32296183
Intra	RHOBTB3	O94955	IHO1	Homo sapiens	Q8IYA8	Y2H Array	32296183
Intra	RHOBTB3	O94955	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	32296183
Cross	RHOBTB3	O94955	RAB9A	Canis familiaris	P24408	ATPase Assay	19490898
Cross	RHOBTB3	O94955	RAB9A	Canis familiaris	P24408	Pull Down	19490898
Cross	RHOBTB3	O94955	RAB9A	Canis familiaris	P24408	Y2H	19490898

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Proprotein Convertase 1/3 Deficiency	Obesity Due To Prohormone Convertase I Deficiency Obesity With Impaired Prohormone Processing Obesity And Endocrinopathy Due To Impaired Processing Of Prohormones Pci Deficiency Proprotein Convertase 1 3 Deficiency Endocrinopathy Due To Proprotein Convertase 1/3 Deficiency Proprotein Convertase 1 Deficiency PC1 DEFICIENCY

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11949	RHOBTB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RHOBTB3	VGNC	VGNC:76773
Felis catus	RHOBTB3	VGNC	VGNC:64615
Canis familiaris	RHOBTB3	VGNC	VGNC:53200
Mus musculus	RHOBTB3	MGD	MGI:1920546
Bos taurus	RHOBTB3	VGNC	VGNC:33946
Rattus norvegicus	RHOBTB3	RGD	RGD:1311683
Others	RHOBTB3	NCBI