PABPC1 - poly(A) binding protein cytoplasmic 1 Gene

Also Known as PAB1; PABP; PABP1; PABPC2; PABPL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26986

About PABPC1

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:100,702,916-100,722,088 (from NCBI)

This gene has 40 transcripts (splice variants), 148 orthologues, 24 paralogues and is associated with 73 phenotypes. Ubiquitous expression in esophagus (RPKM 345.6), urinary bladder (RPKM 280.1) and 25 other tissues.

Summary

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

PABPC1 Products (1)

mRNA Protein Name
NM_002568.4 NP_002559.2 polyadenylate-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
25225333 GOA
enables RNA binding IPI
IPI: Inferred from physical interaction
23041282 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
16126846 GOA
enables mRNA binding EXP
EXP: Inferred from Experiment
23041282 GOA
enables poly(A) binding IDA
IDA: Inferred from direct assay
16804161 GOA
enables poly(U) RNA binding IDA
IDA: Inferred from direct assay
21984414 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11051545 GOA
Biological Process GO Annotation Evidence References Source
involved in CRD-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
11051545 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
11051545 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
IDA: Inferred from direct assay
18447585 GOA
involved in positive regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
11051545 GOA
involved in positive regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
26735137 GOA
Cellular Component GO Annotation Evidence References Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in cell leading edge IDA
IDA: Inferred from direct assay
28733330 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
28733330 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: Inferred from direct assay
15121898 GOA
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
21883093 GOA
located in cytosol IDA
IDA: Inferred from direct assay
11051545 GOA
part of mCRD-mediated mRNA stability complex IPI
IPI: Inferred from physical interaction
11051545 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21940797 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17289661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PABPC1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (13 - 83)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (101 - 168)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (193 - 261)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (296 - 363)

PABP

PABP: Poly-adenylate binding protein, unique domain (543 - 614)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 636 a.a.
Protein Preferred Names Protein Names

polyadenylate-binding protein 1

  • poly(A) binding protein, cytoplasmic 2

PABPC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PABPC1 P11940 LARP4B Homo sapiens Q92615
Phage Display
35044719
Intra
PABPC1 P11940 PABPN1 Homo sapiens Q86U42
Anti Tag CoIP
23665581
Intra
PABPC1 P11940 TNRC6A Homo sapiens Q8NDV7
Anti Bait CoIP
28877994
Intra
PABPC1 P11940 TNRC6A Homo sapiens Q8NDV7
Anti Tag CoIP
21063388
Intra
PABPC1 P11940 PAN3 Homo sapiens Q58A45
Pull Down
17595167
Intra
PABPC1 P11940 PAN3 Homo sapiens Q58A45
NMR
17595167
Cross
PABPC1 P11940 N SARS-CoV-2 P0DTC9
Y2H Array
36217030
Intra
PABPC1 P11940 TOB2 Homo sapiens Q14106
Phage Display
35044719
Intra
PABPC1 P11940 PAIP2 Homo sapiens Q9BPZ3
NMR
14685257
Intra
PABPC1 P11940 PAIP2 Homo sapiens Q9BPZ3
Pull Down
14685257
Intra
PABPC1 P11940 PAIP2 Homo sapiens Q9BPZ3
Anti Bait CoIP
16601676
Intra
PABPC1 P11940 PAIP2 Homo sapiens Q9BPZ3
FPS
37100772
Intra
PABPC1 P11940 PAIP2 Homo sapiens Q9BPZ3
ITC
14685257
Intra
PABPC1 P11940 DDX3X Homo sapiens O00571
Pull Down
21883093
Intra
PABPC1 P11940 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
PABPC1 P11940 GSPT2 Homo sapiens Q8IYD1
Pull Down
14685257
Intra
PABPC1 P11940 GSPT2 Homo sapiens Q8IYD1
Phage Display
35044719
Intra
PABPC1 P11940 GSPT2 Homo sapiens Q8IYD1
SPR
14685257
Intra
PABPC1 P11940 HNRNPD Homo sapiens Q14103-4
Pull Down
16556936
Intra
PABPC1 P11940 NCBP1 Homo sapiens Q09161
Anti Tag CoIP
23665581
Intra
PABPC1 P11940 TNRC6C Homo sapiens Q9HCJ0-1
Anti Tag CoIP
21063388
Intra
PABPC1 P11940 TNRC6C Homo sapiens Q9HCJ0
Pull Down
19716330
Intra
PABPC1 P11940 TNRC6C Homo sapiens Q9HCJ0
X-Ray Diffraction
20181956
Intra
PABPC1 P11940 TNRC6C Homo sapiens Q9HCJ0
NMR
20181956
Intra
PABPC1 P11940 ATXN2 Homo sapiens Q99700
X-Ray Diffraction
20181956
Intra
PABPC1 P11940 ATXN2 Homo sapiens Q99700
IF
15663938
Intra
PABPC1 P11940 TOB1 Homo sapiens P50616
ITC
20595394
Intra
PABPC1 P11940 TOB1 Homo sapiens P50616
NMR
20595394
Intra
PABPC1 P11940 EIF4E Homo sapiens P06730
Anti Tag CoIP
23665581
Intra
PABPC1 P11940 EIF4G1 Homo sapiens Q04637
ITC
12086624
Intra
PABPC1 P11940 EIF4G1 Homo sapiens Q04637
CoIP
9857202
Intra
PABPC1 P11940 PAIP1 Homo sapiens Q9H074
MST
33876849
Intra
PABPC1 P11940 PAIP1 Homo sapiens Q9H074
Far-WB
11997512
Intra
PABPC1 P11940 PAIP1 Homo sapiens Q9H074
SPR
11997512
Intra
PABPC1 P11940 PAIP1 Homo sapiens Q9H074
Pull Down
9548260
Intra
PABPC1 P11940 PAIP1 Homo sapiens Q9H074
Pull Down
11997512
Intra
PABPC1 P11940 PAIP1 Homo sapiens Q9H074
NMR
14685257
Intra
PABPC1 P11940 PAIP1 Homo sapiens Q9H074
Pull Down
14685257
Intra
PABPC1 P11940 PAIP1 Homo sapiens Q9H074
FPS
37100772
Intra
PABPC1 P11940 PAIP1 Homo sapiens Q9H074
Anti Tag CoIP
33876849
Cross
PABPC1 P11940 N Human coronavirus 229E P15130
X-Ray Diffraction
37100772
Cross
PABPC1 P11940 N Human coronavirus 229E P15130
Pull Down
37100772
Intra
PABPC1 P11940 GSPT1 Homo sapiens P15170-2
X-Ray Diffraction
20418951
Intra
PABPC1 P11940 TNRC6B Homo sapiens Q9UPQ9
Pull Down
21063388
Cross
PABPC1 P11940 L Lymphocytic choriomeningitis virus P14240
Anti Tag CoIP
29261807
Cross
PABPC1 P11940 P/V/C Hendra virus O55778
FPS
37100772
Cross
PABPC1 P11940 P/V/C Hendra virus O55778
Pull Down
37100772
Cross: Cross-species interaction Intra: Intraspecies interaction

PABPC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87003 PABP Antibody (YA6696) WB, ICC/IF, IHC-P, FC, IF-Tissue Human, Mouse, Monkey

Related Diseases

Diseases Alias
Rift Valley Fever

  • Rfv - [Rift Valley Fever]
Dengue Virus

  • Dengue Virus, Susceptibility To

  • Dengue Fever, Protection Against

  • Dengue Fever
Motor Neuron Disease

  • Anterior Horn Cell Disease

  • Motor Neuron Diseases

  • Mnd - [Motor Neurone Disease]

  • Lou Gehrig Disease

  • Creeping Palsy

  • Creeping Paralysis

  • Bulbar Motor Neuron Disease

  • Bulbar Syndrome

  • Anterior Horn Cell Disorder

  • Hereditary Motor Neuron Disease
Lymphocytic Choriomeningitis

  • Lcm

  • Lymphocytic Meningitis

  • Lymphocytic Choriomeningitis Virus Encephalomyelitis

  • Lymphocytic Meningoencephalitis

  • Non-Arthropod Borne Lymphocytic Choriomeningitis

  • Lcm - [Lymphocytic Choriomeningitis]

  • Benign Lymphocytic Meningitis

  • Meningitis Due To Lymphocytic Choriomeningitis Virus
Multisystem Proteinopathy
Waardenburg Syndrome, Type 4a

  • Waardenburg-Shah Syndrome

  • Shah-Waardenburg Syndrome

  • Waardenburg Syndrome Type 4a

  • WS4A

  • Ws4

  • Waardenburg Syndrome Type 4

  • Waardenburg Syndrome Type Iva

  • Waardenburg Syndrome With Hirschsprung Disease Type 4a

  • Hirschsprung Disease With Pigmentary Anomaly

  • Waardenburg-Hirschsprung Syndrome

  • Waardenburg Syndrome, Type Iva

  • Waardenburg Syndrome With Hirschsprung Disease, Type 4a

  • Waardenburg-Hirschsprung Disease

  • Waardenburg Syndrome, Type 4

  • Waardenburg Syndrome 4a
Autosomal Dominant Cerebellar Ataxia

  • Spinocerebellar Ataxia

  • Adca

  • Pierre Marie Cerebellar Ataxia

  • Ataxia, Spinocerebellar

  • Sca

  • Autosomal Dominant Spinocerebellar Ataxia

  • Spinocerebellar Ataxias
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09948 PABPC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19518 Pabpc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26013 Pabpc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990727 Alextatug / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PABPC1 VGNC VGNC:81701
Canis familiaris PABPC1 VGNC VGNC:51778
Bos taurus PABPC1 VGNC VGNC:53870
Macaca mulatta PABPC1 VGNC VGNC:84098
Mus musculus PABPC1 MGD MGI:1349722
Rattus norvegicus PABPC1 RGD RGD:619838
Others PABPC1 NCBI