PABPC1 - poly(A) binding protein cytoplasmic 1 Gene

Homo sapiens

Also known as PAB1; PABP; PABP1; PABPC2; PABPL1

Gene ID: 26986 | Gene type: protein coding

About PABPC1

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:100,702,916-100,722,088 (from NCBI)

This gene has 40 transcripts (splice variants), 148 orthologues, 24 paralogues and is associated with 73 phenotypes. Ubiquitous expression in esophagus (RPKM 345.6), urinary bladder (RPKM 280.1) and 25 other tissues.

Summary

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

PABPC1 Products(1)

mRNA	Protein	Name
NM_002568.4	NP_002559.2	polyadenylate-binding protein 1

PABPC1 Protein Structure

RRM_1

PABP

0
100
200
300
400
500
600
636 a.a.

Protein Preferred Names

Protein Names

polyadenylate-binding protein 1

poly(A) binding protein, cytoplasmic 2

Related Diseases

Diseases

Alias

Rift Valley Fever

Rfv - [Rift Valley Fever]

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Lymphocytic Choriomeningitis

Lcm	Lymphocytic Meningitis
Lymphocytic Choriomeningitis Virus Encephalomyelitis	Lymphocytic Meningoencephalitis
Non-Arthropod Borne Lymphocytic Choriomeningitis	Lcm - [Lymphocytic Choriomeningitis]
Benign Lymphocytic Meningitis	Meningitis Due To Lymphocytic Choriomeningitis Virus

Multisystem Proteinopathy

Waardenburg Syndrome, Type 4a

Waardenburg-Shah Syndrome	Shah-Waardenburg Syndrome
Waardenburg Syndrome Type 4a	WS4A
Ws4	Waardenburg Syndrome Type 4
Waardenburg Syndrome Type Iva	Waardenburg Syndrome With Hirschsprung Disease Type 4a
Hirschsprung Disease With Pigmentary Anomaly	Waardenburg-Hirschsprung Syndrome
Waardenburg Syndrome, Type Iva	Waardenburg Syndrome With Hirschsprung Disease, Type 4a
Waardenburg-Hirschsprung Disease	Waardenburg Syndrome, Type 4
Waardenburg Syndrome 4a

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09948	PABPC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PABPC1	VGNC	VGNC:81701
Canis familiaris	PABPC1	VGNC	VGNC:51778
Bos taurus	PABPC1	VGNC	VGNC:53870
Macaca mulatta	PABPC1	VGNC	VGNC:84098
Mus musculus	PABPC1	MGD	MGI:1349722
Rattus norvegicus	PABPC1	RGD	RGD:619838

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