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TNRC6A - trinucleotide repeat containing adaptor 6A Gene

Also Known as GW1; FAME6; GW182; TNRC6; CAGH26

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27327

About TNRC6A

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:24,610,205-24,826,218 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 205 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 11.5), endometrium (RPKM 10.0) and 25 other tissues.

Summary

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and MicroRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes Other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

TNRC6A Products (3)

mRNA	Protein	Name
NM_001330520.3	NP_001317449.1	trinucleotide repeat-containing gene 6A protein isoform 2
NM_001351850.2	NP_001338779.1	trinucleotide repeat-containing gene 6A protein isoform 3
NM_014494.4	NP_055309.2	trinucleotide repeat-containing gene 6A protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19167051	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in P-body assembly	IDA IDA: Inferred from direct assay	31400113	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	17671087	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IMP IMP: Inferred from mutant phenotype	23172285	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in P-body	IDA IDA: Inferred from direct assay	31400113	GOA
located in P-body	IDA IDA: Inferred from direct assay	20616046	GOA
part of RISC complex	IDA IDA: Inferred from direct assay	17671087	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNRC6A Protein Structure

Ago_hook

RRM_5

0
400
800
1200
1600
1962 a.a.

Protein Preferred Names	Protein Names
trinucleotide repeat-containing gene 6A protein	CAG repeat protein 26

TNRC6A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNRC6A	Q8NDV7	CNOT1	Homo sapiens	A5YKK6	Anti Bait CoIP	21981923
Intra	TNRC6A	Q8NDV7	AGO3	Homo sapiens	Q9H9G7	Confocal	19383768
Intra	TNRC6A	Q8NDV7	AGO3	Homo sapiens	Q9H9G7	Pull Down	19324964
Intra	TNRC6A	Q8NDV7	AGO3	Homo sapiens	Q9H9G7	Anti Tag CoIP	19383768
Intra	TNRC6A	Q8NDV7	AGO4	Homo sapiens	Q9HCK5	Confocal	19383768
Intra	TNRC6A	Q8NDV7	AGO4	Homo sapiens	Q9HCK5	Anti Tag CoIP	19383768
Intra	TNRC6A	Q8NDV7	PAN3	Homo sapiens	Q58A45	Anti Bait CoIP	21981923
Intra	TNRC6A	Q8NDV7	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	25416956
Intra	TNRC6A	Q8NDV7	AGO1	Homo sapiens	Q9UL18	Anti Tag CoIP	33961781
Intra	TNRC6A	Q8NDV7	AGO1	Homo sapiens	Q9UL18	Pull Down	19324964
Intra	TNRC6A	Q8NDV7	AGO1	Homo sapiens	Q9UL18	Confocal	19383768
Intra	TNRC6A	Q8NDV7	AGO1	Homo sapiens	Q9UL18	Anti Tag CoIP	19383768
Intra	TNRC6A	Q8NDV7	AGO1	Homo sapiens	Q9UL18	Anti Bait CoIP	22484317
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	28877994
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	PLA	28683311
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Confocal	19383768
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Confocal	28877994
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	19383768
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	22484317
Intra	TNRC6A	Q8NDV7	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	21840310
Intra	TNRC6A	Q8NDV7	PABPC1	Homo sapiens	P11940	Anti Bait CoIP	28877994

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Epilepsy, Familial Adult Myoclonic, 6	FAME6 Benign Adult Familial Myoclonic Epilepsy 6 Bafme6 Fcmte6 Cortical Myoclonic Tremor With Epilepsy, Familial, 6 Familial Adult Myoclonic Epilepsy 6 Familial Cortical Myoclonic Tremor And Epilepsy 6 Epilepsy, Myoclonic, Familial Adult, Type 6
Epilepsy, Familial Adult Myoclonic, 1	FAME1 Benign Adult Familial Myoclonic Epilepsy 1 Bafme1 Fcmte1 Cortical Myoclonic Tremor With Epilepsy, Familial, 1 Familial Adult Myoclonic Epilepsy 1 Familial Cortical Myoclonic Tremor And Epilepsy 1 Epilepsy, Myoclonic, Familial Adult, Type 1
Epilepsy, Familial Adult Myoclonic, 7	FAME7 Bafme7 Fcmte7 Benign Adult Familial Myoclonic Epilepsy 7 Cortical Myoclonic Tremor With Epilepsy, Familial, 7 Familial Adult Myoclonic Epilepsy 7 Familial Cortical Myoclonic Tremor And Epilepsy 7 Benign Adult Familial Myoclonic Epilepsy 27 Epilepsy, Myoclonic, Familial Adult, Type 7
Epilepsy, Familial Adult Myoclonic, 2	FAME2 Benign Adult Familial Myoclonic Epilepsy 2 Bafme2 Fcmte2 Adcme Cortical Myoclonic Tremor With Epilepsy, Familial, 2 Cortical Myoclonus And Epilepsy, Autosomal Dominant Familial Adult Myoclonic Epilepsy 2 Epilepsy, Myoclonic, Benign Adult Familial, Type 2 Autosomal Dominant Cortical Myoclonus And Epilepsy Familial Cortical Myoclonic Tremor And Epilepsy 2 Epilepsy, Myoclonic, Familial Adult, Type 2
Epilepsy, Familial Adult Myoclonic, 3	FAME3 Fcmte3 Cortical Myoclonic Tremor With Epilepsy, Familial, 3 Familial Adult Myoclonic Epilepsy 3 Familial Cortical Myoclonic Tremor And Epilepsy 3 Epilepsy, Myoclonic, Familial Adult, Type 3
Epilepsy, Familial Adult Myoclonic, 4	FAME4 Fcmte4 Cortical Myoclonic Tremor With Epilepsy, Familial, 4 Familial Adult Myoclonic Epilepsy 4 Epilepsy, Myoclonic, Familial Adult, 4 Familial Cortical Myoclonic Tremor And Epilepsy 4 Epilepsy, Myoclonic, Familial Adult, Type 4
Familial Adult Myoclonic Epilepsy	Benign Adult Familial Myoclonus Epilepsy Bafme Benign Adult Familial Myoclonic Epilepsy Fame Familial Cortical Myoclonic Tremor And Epilepsy Fcmte Adcme Autosomal Dominant Cortical Myoclonus And Epilepsy Fam Epilepsy, Myoclonic, Familial Adult Epilepsy, Myoclonic, Benign Adult Familial, Type 2
Cervical Non-Keratinizing Squamous Cell Carcinoma
Granulomatous Disease, Chronic, Autosomal Recessive, 3	CGD3 Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii Granulomatous Disease, Chronic, Due To Ncf4 Deficiency Chronic Granulomatous Disease 3, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 3 Autosomal Recessive Cytochrome B-Positive Cgd Type Iii Cdg3 Chronic Granulomatous Disease Due To Ncf4 Deficiency Cgd Autosomal Recessive Cytochrome B-Positive Type Iii Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii Granulomatous Disease Chronic Due To Ncf4 Deficiency Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3
Mild Cognitive Impairment
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Adolescence-Adult Electroclinical Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14864	TNRC6A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNRC6A	VGNC	VGNC:36204
Felis catus	TNRC6A	VGNC	VGNC:80697
Canis familiaris	TNRC6A	VGNC	VGNC:47699
Macaca mulatta	TNRC6A	VGNC	VGNC:78611
Mus musculus	TNRC6A	MGD	MGI:2385292
Rattus norvegicus	TNRC6A	RGD	RGD:1307268
Others	TNRC6A	NCBI