AGO4 - argonaute RISC component 4 Gene

Homo sapiens

Also known as EIF2C4

Gene ID: 192670 | Gene type: protein coding

About AGO4

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,807,636-35,857,890 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 3 paralogues. Ubiquitous expression in skin (RPKM 10.1), bone marrow (RPKM 8.1) and 25 other tissues.

Summary

This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]

AGO4 Products(1)

mRNA	Protein	Name
NM_017629.4	NP_060099.2	protein argonaute-4

AGO4 Protein Structure

ArgoL1

PAZ

Piwi

0
200
400
600
800
861 a.a.

Protein Preferred Names

Protein Names

protein argonaute-4

argonaute 4, RISC catalytic component

Related Diseases

Diseases

Alias

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Epiphyseal Dysplasia, Multiple, 2

EDM2	Multiple Epiphyseal Dysplasia 2
Dysplasia, Epiphyseal, Multiple, Type 2

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00455	AGO4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AGO4	VGNC	VGNC:25733
Felis catus	AGO4	VGNC	VGNC:80129
Rattus norvegicus	AGO4	RGD	RGD:1304583
Mus musculus	AGO4	MGD	MGI:1924100
Canis familiaris	AGO4	VGNC	VGNC:37709
Macaca mulatta	AGO4	VGNC	VGNC:81348