AGO4 - argonaute RISC component 4 Gene

Also Known as EIF2C4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 192670

About AGO4

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,807,636-35,857,890 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 3 paralogues. Ubiquitous expression in skin (RPKM 10.1), bone marrow (RPKM 8.1) and 25 other tissues.

Summary

This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]

AGO4 Products (1)

mRNA	Protein	Name
NM_017629.4	NP_060099.2	protein argonaute-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	19966796	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	15260970	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15766526	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	19966796	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RISC complex assembly	IDA IDA: Inferred from direct assay	19966796	GOA
involved in RNA secondary structure unwinding	IDA IDA: Inferred from direct assay	19966796	GOA
involved in RNA secondary structure unwinding	IMP IMP: Inferred from mutant phenotype	22795694	GOA
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	18771919	GOA
involved in miRNA processing	IMP IMP: Inferred from mutant phenotype	22795694	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	18771919	GOA
NOT involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	15260970	GOA
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	19966796	GOA
NOT involved in siRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	15260970	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RISC complex	IDA IDA: Inferred from direct assay	15260970	GOA
part of RISC-loading complex	IDA IDA: Inferred from direct assay	19966796	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15260970	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGO4 Protein Structure

ArgoL1

PAZ

Piwi

0
200
400
600
800
861 a.a.

Protein Preferred Names	Protein Names
protein argonaute-4	argonaute 4, RISC catalytic component

AGO4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AGO4	Q9HCK5	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	19167051
Intra	AGO4	Q9HCK5	TNRC6A	Homo sapiens	Q8NDV7	Pull Down	19324964
Intra	AGO4	Q9HCK5	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	33961781
Intra	AGO4	Q9HCK5	IPO8	Homo sapiens	O15397	Anti Tag CoIP	19167051
Intra	AGO4	Q9HCK5	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	33961781
Intra	AGO4	Q9HCK5	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	19383768

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia
Epiphyseal Dysplasia, Multiple, 2	EDM2 Multiple Epiphyseal Dysplasia 2 Dysplasia, Epiphyseal, Multiple, Type 2
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00455	AGO4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AGO4	VGNC	VGNC:25733
Felis catus	AGO4	VGNC	VGNC:80129
Rattus norvegicus	AGO4	RGD	RGD:1304583
Mus musculus	AGO4	MGD	MGI:1924100
Canis familiaris	AGO4	VGNC	VGNC:37709
Macaca mulatta	AGO4	VGNC	VGNC:81348
Others	AGO4	NCBI