TNRC6C - trinucleotide repeat containing adaptor 6C Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57690

About TNRC6C

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:77,957,557-78,108,835 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 4.2), testis (RPKM 3.1) and 25 other tissues.

Summary

Predicted to enable RNA binding activity. Involved in gene silencing by miRNA; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNRC6C Products (7)

mRNA Protein Name
NM_001142640.2 NP_001136112.2 trinucleotide repeat-containing gene 6C protein isoform 1
NM_001395508.1 NP_001382437.1 trinucleotide repeat-containing gene 6C protein isoform 3
NM_001395509.1 NP_001382438.1 trinucleotide repeat-containing gene 6C protein isoform 4
NM_001395510.1 NP_001382439.1 trinucleotide repeat-containing gene 6C protein isoform 5
NM_001395511.1 NP_001382440.1 trinucleotide repeat-containing gene 6C protein isoform 6
NM_001395512.1 NP_001382441.1 trinucleotide repeat-containing gene 6C protein isoform 7
NM_018996.3 NP_061869.2 trinucleotide repeat-containing gene 6C protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19383768 GOA
Biological Process GO Annotation Evidence References Source
involved in miRNA-mediated post-transcriptional gene silencing IGI
IGI: Inferred from genetic interaction
23172285 GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
21984185 GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
IDA: Inferred from direct assay
21984185 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNRC6C Protein Structure

Ago_hook

Ago_hook: Argonaute hook (818 - 942)

UBA

UBA: UBA/TS-N domain (943 - 973)

M_domain

M_domain: M domain of GW182 (991 - 1249)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (1530 - 1584)

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  • 1690 a.a.
Protein Preferred Names Protein Names

trinucleotide repeat-containing gene 6C protein

  • trinucleotide repeat containing 6C

TNRC6C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNRC6C Q9HCJ0 CNOT6L Homo sapiens Q96LI5
Pull Down
21984185
Intra
TNRC6C Q9HCJ0 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
21981923
Intra
TNRC6C Q9HCJ0 CNOT10 Homo sapiens Q9H9A5
Pull Down
21984185
Intra
TNRC6C Q9HCJ0 CNOT10 Homo sapiens Q9H9A5
Anti Tag CoIP
21981923
Intra
TNRC6C Q9HCJ0 CNOT1 Homo sapiens A5YKK6
Pull Down
21984185
Intra
TNRC6C Q9HCJ0 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
21981923
Intra
TNRC6C Q9HCJ0 CNOT6 Homo sapiens Q9ULM6
Anti Tag CoIP
21981923
Intra
TNRC6C Q9HCJ0 CNOT7 Homo sapiens Q9UIV1
Anti Tag CoIP
21981923
Intra
TNRC6C Q9HCJ0 CNOT7 Homo sapiens Q9UIV1
Pull Down
21984185
Intra
TNRC6C Q9HCJ0 AGO4 Homo sapiens Q9HCK5
Confocal
19383768
Intra
TNRC6C Q9HCJ0 PAN3 Homo sapiens Q58A45
Anti Tag CoIP
21981923
Cross
TNRC6C Q9HCJ0 Ago2 Mus musculus Q8CJG0
Anti Tag CoIP
23340509
Intra
TNRC6C Q9HCJ0 CNOT2 Homo sapiens Q9NZN8
Pull Down
21984185
Intra
TNRC6C Q9HCJ0 CNOT2 Homo sapiens Q9NZN8
Anti Tag CoIP
21981923
Intra
TNRC6C Q9HCJ0 CNOT3 Homo sapiens O75175
Pull Down
21984185
Intra
TNRC6C Q9HCJ0 CNOT3 Homo sapiens O75175
Anti Tag CoIP
21981923
Intra
TNRC6C Q9HCJ0 PABPC1 Homo sapiens P11940
X-Ray Diffraction
20098421
Intra
TNRC6C Q9HCJ0 PABPC1 Homo sapiens P11940
ITC
20181956
Intra
TNRC6C Q9HCJ0 PABPC1 Homo sapiens P11940
Anti Tag CoIP
23340509
Intra
TNRC6C Q9HCJ0 PABPC1 Homo sapiens P11940
GMS
20098421
Intra
TNRC6C Q9HCJ0 PABPC1 Homo sapiens P11940
Anti Tag CoIP
21981923
Intra
TNRC6C Q9HCJ0 PABPC1 Homo sapiens P11940
NMR
20181956
Intra
TNRC6C Q9HCJ0 PABPC1 Homo sapiens P11940
Pull Down
19716330
Intra
TNRC6C Q9HCJ0 PABPC1 Homo sapiens P11940
Pull Down
20098421
Intra
TNRC6C Q9HCJ0 PABPC1 Homo sapiens P11940
Anti Tag CoIP
19716330
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14866 TNRC6C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TNRC6C VGNC VGNC:47700
Rattus norvegicus TNRC6C RGD RGD:1310027
Macaca mulatta TNRC6C VGNC VGNC:79800
Mus musculus TNRC6C MGD MGI:2443265
Bos taurus TNRC6C VGNC VGNC:36206
Felis catus TNRC6C VGNC VGNC:99564
Others TNRC6C NCBI