CNOT6 - CCR4-NOT transcription complex subunit 6 Gene

Also Known as CCR4; Ccr4a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57472

About CNOT6

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:180,494,379-180,578,358 (from NCBI)

This gene has 7 transcripts (splice variants), 235 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 8.0), urinary bladder (RPKM 6.4) and 25 other tissues.

Summary

This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]

CNOT6 Products (3)

mRNA	Protein	Name
NM_001370472.1	NP_001357401.1	CCR4-NOT transcription complex subunit 6 isoform 1
NM_001370473.1	NP_001357402.1	CCR4-NOT transcription complex subunit 6 isoform 2
NM_001370474.1	NP_001357403.1	CCR4-NOT transcription complex subunit 6 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA exonuclease activity	IDA IDA: Inferred from direct assay	11889047	GOA
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	18180299	GOA
enables poly(A)-specific ribonuclease activity	IDA IDA: Inferred from direct assay	11889047	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11747467	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	20065043	GOA
involved in nuclear-transcribed mRNA catabolic process, no-go decay	IMP IMP: Inferred from mutant phenotype	15314026	GOA
involved in nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: Inferred from mutant phenotype	20595389	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21233283	GOA
involved in positive regulation of cytoplasmic mRNA processing body assembly	IMP IMP: Inferred from mutant phenotype	21233283	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	19558367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT6 Protein Structure

LRR_8

Exo_endo_phos

0
100
200
300
400
500
557 a.a.

Protein Preferred Names	Protein Names
CCR4-NOT transcription complex subunit 6	carbon catabolite repression 4 protein

CNOT6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CNOT6	Q9ULM6	CNOT10	Homo sapiens	Q9H9A5	Anti Tag CoIP	17452450
Intra	CNOT6	Q9ULM6	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	22977175
Intra	CNOT6	Q9ULM6	CNOT7	Homo sapiens	Q9UIV1	Far-WB	11747467
Intra	CNOT6	Q9ULM6	CNOT7	Homo sapiens	Q9UIV1	Y2H	11747467
Intra	CNOT6	Q9ULM6	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	21981923
Intra	CNOT6	Q9ULM6	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	17452450

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02905	CNOT6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02906	CNOT6L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CNOT6	VGNC	VGNC:61028
Bos taurus	CNOT6	VGNC	VGNC:27520
Macaca mulatta	CNOT6	VGNC	VGNC:71175
Mus musculus	CNOT6	MGD	MGI:2144529
Rattus norvegicus	CNOT6	RGD	RGD:1310783
Canis familiaris	CNOT6	VGNC	VGNC:39416