CNOT1 - CCR4-NOT transcription complex subunit 1 Gene

Also Known as NOT1; CDC39; HPE12; NOT1H; VIBOS; AD-005

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23019

About CNOT1

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,519,951-58,629,826 (from NCBI)

This gene has 22 transcripts (splice variants), 215 orthologues and is associated with 5 phenotypes. Ubiquitous expression in testis (RPKM 56.3), esophagus (RPKM 28.6) and 25 other tissues.

Summary

Enables armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex. Implicated in holoprosencephaly. [provided by Alliance of Genome Resources, Apr 2022]

CNOT1 Products (3)

mRNA	Protein	Name
NM_001265612.2	NP_001252541.1	CCR4-NOT transcription complex subunit 1 isoform c
NM_016284.5	NP_057368.3	CCR4-NOT transcription complex subunit 1 isoform a
NM_206999.3	NP_996882.1	CCR4-NOT transcription complex subunit 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables armadillo repeat domain binding	IPI IPI: Inferred from physical interaction	24768540	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	22977175	GOA
enables nuclear estrogen receptor binding	IDA IDA: Inferred from direct assay	16778766	GOA
enables nuclear retinoic acid receptor binding	IDA IDA: Inferred from direct assay	16778766	GOA
contributes to poly(A)-specific ribonuclease activity	IDA IDA: Inferred from direct assay	21976065	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10637334	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	24768540	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	23172285	GOA
involved in negative regulation of intracellular estrogen receptor signaling pathway	IDA IDA: Inferred from direct assay	16778766	GOA
involved in negative regulation of retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	16778766	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16778766	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	24736845	GOA
involved in positive regulation of cytoplasmic mRNA processing body assembly	IDA IDA: Inferred from direct assay	21976065	GOA
involved in positive regulation of mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	22977175	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP IMP: Inferred from mutant phenotype	21278420	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	23644599	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: Inferred from mutant phenotype	21278420	GOA
involved in regulation of stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	22367759	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	19558367	GOA
located in P-body	IDA IDA: Inferred from direct assay	21976065	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT1 Protein Structure

DUF3819

Not1

0
400
800
1200
1600
2000
2376 a.a.

Protein Preferred Names	Protein Names
CCR4-NOT transcription complex subunit 1	CCR4-associated factor 1

CNOT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CNOT1	A5YKK6	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450
Intra	CNOT1	A5YKK6	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	17452450
Intra	CNOT1	A5YKK6	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	21278420
Intra	CNOT1	A5YKK6	CNOT7	Homo sapiens	Q9UIV1	X-Ray Diffraction	22977175
Intra	CNOT1	A5YKK6	ANXA2R	Homo sapiens	Q3ZCQ2	Pull Down	30833792
Intra	CNOT1	A5YKK6	ANXA2R	Homo sapiens	Q3ZCQ2	Confocal	30833792
Intra	CNOT1	A5YKK6	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	21981923
Intra	CNOT1	A5YKK6	CNOT11	Homo sapiens	Q9UKZ1	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	TNRC6C	Homo sapiens	Q9HCJ0-1	Anti Tag CoIP	23463101
Cross	CNOT1	A5YKK6	Zfp36	Mus musculus	P22893	Anti Tag CoIP	21278420
Intra	CNOT1	A5YKK6	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	21981923
Intra	CNOT1	A5YKK6	TOB1	Homo sapiens	P50616	TAP	18377426
Intra	CNOT1	A5YKK6	TOB1	Homo sapiens	P50616	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	TOB1	Homo sapiens	P50616	Anti Tag CoIP	18377426
Intra	CNOT1	A5YKK6	CNOT8	Homo sapiens	Q9UFF9	Pull Down	22977175
Intra	CNOT1	A5YKK6	CNOT8	Homo sapiens	Q9UFF9	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	CNOT2	Homo sapiens	Q9NZN8	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	26496610
Intra	CNOT1	A5YKK6	TNRC6B	Homo sapiens	Q9UPQ9	Pull Down	21981923

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Holoprosencephaly 12 With Or Without Pancreatic Agenesis	HPE12 Holoprosencephaly 12, With Or Without Pancreatic Agenesis Pancreatic Agenesis-Holoprosencephaly Syndrome
Vissers-Bodmer Syndrome	VIBOS
Alopecia-Intellectual Disability Syndrome 4	Alopecia-Mental Retardation Syndrome 4 APMR4
Pancreatic Agenesis	Partial Pancreatic Agenesis Congenital Pancreatic Agenesis Partial Agenesis Of The Pancreas Agenesis, Pancreatic Pancreatic Agenesis, Congenital
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Spermatogenic Failure 11	SPGF11
Anemia, Congenital Dyserythropoietic, Type Ia	Congenital Dyserythropoietic Anemia Type I Cda I CDAN1A Congenital Dyserythropoietic Anemia Type 1 Congenital Dyserythropoietic Anemia Type Ia Congenital Dyserythropoietic Anemia, Type I Anemia, Congenital Dyserythropoietic, Type I Cda Type 1 Cda Type I Cda Ia Dyserythropoietic Anemia, Congenital Type 1 Anemia, Congenital Dyserythropoietic, Type 1a Dyserythropoietic Anemia, Congenital, Type Ia Cda, Type Ia Congenital Dyserythropoietic Anaemia Type 1 Congenital Dyserythropoietic Anaemia Type I Anemia, Dyserythropoietic, Congenital Type 1 Type I Congenital Dyserythropoietic Anemia Anemia, Congenital Dyserythropoietic, 1a Anemia, Dyserythropoietic, Congenital, Type Ia
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Gaucher Disease, Type Ii	GD2 Gd Ii Gaucher Disease, Acute Neuronopathic Type Gaucher Disease Type 2 Gaucher Disease Type Ii Gaucher'S Disease Type Ii Infantile Cerebral Gaucher Disease Acute Neuronopathic Gaucher Disease Gd 2 Gaucher Disease, Infantile Cerebral Gaucher Disease 2 Type 2 Gaucher Disease Gaucher Disease, Type 2
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS22450	Cnot1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02899	CNOT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28973	Cnot1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CNOT1	VGNC	VGNC:71386
Felis catus	CNOT1	VGNC	VGNC:68516
Bos taurus	CNOT1	VGNC	VGNC:27514
Rattus norvegicus	CNOT1	RGD	RGD:1308009
Mus musculus	CNOT1	MGD	MGI:2442402
Canis familiaris	CNOT1	VGNC	VGNC:39410
Others	CNOT1	NCBI