CNOT8 - CCR4-NOT transcription complex subunit 8 Gene

Also Known as CAF1; POP2; CALIF; Caf1b; hCAF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9337

About CNOT8

Cytogenetic location: 5q33.2 Genomic coordinates (GRCh38): 5:154,858,249-154,876,792 (from NCBI)

This gene has 25 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 22.1), lymph node (RPKM 19.7) and 25 other tissues.

Summary

Enables poly(A)-specific ribonuclease activity. Involved in exonucleolytic catabolism of deadenylated mRNA and positive regulation of cell population proliferation. Located in nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT8 Products (9)

mRNA Protein Name
NM_001301073.2 NP_001288002.1 CCR4-NOT transcription complex subunit 8 isoform 1
NM_001301074.2 NP_001288003.1 CCR4-NOT transcription complex subunit 8 isoform 2
NM_001301075.2 NP_001288004.1 CCR4-NOT transcription complex subunit 8 isoform 3
NM_001301077.2 NP_001288006.1 CCR4-NOT transcription complex subunit 8 isoform 3
NM_001301080.2 NP_001288009.1 CCR4-NOT transcription complex subunit 8 isoform 3
NM_001301082.1 NP_001288011.1 CCR4-NOT transcription complex subunit 8 isoform 3
NM_001301083.1 NP_001288012.1 CCR4-NOT transcription complex subunit 8 isoform 3
NM_001301086.2 NP_001288015.1 CCR4-NOT transcription complex subunit 8 isoform 4
NM_004779.6 NP_004770.4 CCR4-NOT transcription complex subunit 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5'-RNA exonuclease activity IDA
IDA: Inferred from direct assay
15769875 GOA
enables poly(A)-specific ribonuclease activity IDA
IDA: Inferred from direct assay
15769875 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10637334 GOA
Biological Process GO Annotation Evidence References Source
involved in miRNA-mediated gene silencing by mRNA destabilization IDA
IDA: Inferred from direct assay
20065043 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19605561 GOA
involved in positive regulation of mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
22977175 GOA
Cellular Component GO Annotation Evidence References Source
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
19558367 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9820826 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT8 Protein Structure

CAF1

CAF1: CAF1 family ribonuclease (14 - 239)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 8

  • CAF1-like protein

CNOT8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CNOT8 Q9UFF9 BTG1 Homo sapiens Q6IBC8
Validated Y2H
25416956
Intra
CNOT8 Q9UFF9 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
17452450
Intra
CNOT8 Q9UFF9 BTG2 Homo sapiens P78543
Validated Y2H
25416956
Intra
CNOT8 Q9UFF9 BTG2 Homo sapiens P78543
Y2H
11136725
Intra
CNOT8 Q9UFF9 BTG2 Homo sapiens P78543
Pull Down
11136725
Intra
CNOT8 Q9UFF9 CNOT1 Homo sapiens A5YKK6
Anti Bait CoIP
16778766
Intra
CNOT8 Q9UFF9 CNOT1 Homo sapiens A5YKK6
Anti Bait CoIP
17353931
Intra
CNOT8 Q9UFF9 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
22977175
Intra
CNOT8 Q9UFF9 CNOT1 Homo sapiens A5YKK6
Y2H
10637334
Intra
CNOT8 Q9UFF9 CNOT6 Homo sapiens Q9ULM6
Y2H
11747467
Intra
CNOT8 Q9UFF9 CNOT6 Homo sapiens Q9ULM6
Anti Tag CoIP
17452450
Intra
CNOT8 Q9UFF9 TOB2 Homo sapiens Q14106
Y2H Array
25416956
Intra
CNOT8 Q9UFF9 BTG1 Homo sapiens P62324
Pull Down
11136725
Intra
CNOT8 Q9UFF9 BTG1 Homo sapiens P62324
Y2H Array
31515488
Intra
CNOT8 Q9UFF9 CNOT2 Homo sapiens Q9NZN8
Anti Bait CoIP
16778766
Intra
CNOT8 Q9UFF9 CNOT3 Homo sapiens O75175
Anti Bait CoIP
16778766
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02908 CNOT8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CNOT8 VGNC VGNC:71391
Mus musculus CNOT8 MGD MGI:1916375
Bos taurus CNOT8 VGNC VGNC:27523
Rattus norvegicus CNOT8 RGD RGD:1306401
Felis catus CNOT8 VGNC VGNC:68960
Canis familiaris CNOT8 VGNC VGNC:39419
Others CNOT8 NCBI