CNOT3 - CCR4-NOT transcription complex subunit 3 Gene

Also Known as NOT3; LENG2; NOT3H; IDDSADF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4849

About CNOT3

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,137,762-54,155,681 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 270 orthologues, 1 paralogue and is associated with 74 phenotypes. Ubiquitous expression in testis (RPKM 13.9), spleen (RPKM 9.7) and 25 other tissues.

Summary

Involved in regulation of stem cell population maintenance. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT3 Products (1)

mRNA Protein Name
NM_014516.4 NP_055331.1 CCR4-NOT transcription complex subunit 3

CNOT3 Protein Structure

Not3

Not3: Not1 N-terminal domain, CCR4-Not complex component (3 - 233)

NOT2_3_5

NOT2_3_5: NOT2 / NOT3 / NOT5 family (619 - 748)

  • 0
  • 200
  • 400
  • 600
  • 753 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 3

  • CCR4-associated factor 3

CNOT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CNOT3 O75175 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
33961781
Intra
CNOT3 O75175 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
17452450
Intra
CNOT3 O75175 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
CNOT3 O75175 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
CNOT3 O75175 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
CNOT3 O75175 CNOT1 Homo sapiens A5YKK6
Anti Bait CoIP
16778766
Intra
CNOT3 O75175 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
33961781
Intra
CNOT3 O75175 CNOT6 Homo sapiens Q9ULM6
Anti Tag CoIP
33961781
Intra
CNOT3 O75175 DLST Homo sapiens P36957
Validated Y2H
32814053
Intra
CNOT3 O75175 DLST Homo sapiens P36957
Y2H Pooling
32814053
Intra
CNOT3 O75175 DLST Homo sapiens P36957
Y2H Array
32814053
Intra
CNOT3 O75175 VCP Homo sapiens P55072
Y2H Array
32814053
Intra
CNOT3 O75175 VCP Homo sapiens P55072
Y2H Pooling
32814053
Intra
CNOT3 O75175 VCP Homo sapiens P55072
Validated Y2H
32814053
Cross
CNOT3 O75175 Cand2 Mus musculus Q6ZQ73
Y2H
12207886
Intra
CNOT3 O75175 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
CNOT3 O75175 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
CNOT3 O75175 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
CNOT3 O75175 TOB1 Homo sapiens P50616
Anti Tag CoIP
18377426
Intra
CNOT3 O75175 TOB1 Homo sapiens P50616
TAP
18377426
Intra
CNOT3 O75175 CNOT8 Homo sapiens Q9UFF9
Anti Tag CoIP
33961781
Intra
CNOT3 O75175 CNOT8 Homo sapiens Q9UFF9
Anti Bait CoIP
10637334
Intra
CNOT3 O75175 CNOT8 Homo sapiens Q9UFF9
Y2H
10637334
Intra
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8
Anti Bait CoIP
21984185
Intra
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8
Validated Y2H
32296183
Intra
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8
Anti Bait CoIP
16778766
Intra
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8
Anti Tag CoIP
33961781
Intra
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8
Y2H Array
32296183
Intra
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder With Speech Delay, Autism, And Dysmorphic Facies

  • IDDSADF

  • Intellectual Developmental Disorder With Speech Delay, Autism And Dysmorphic Facies
Precursor T-Cell Acute Lymphoblastic Leukemia

  • T-All

  • Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor T-Cell Acute Lymphocytic Leukemia

  • Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Adult T-Cell Lymphoma/Leukemia
Non-Specific Syndromic Intellectual Disability

  • Complex Neurodevelopmental Disorder
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02903 CNOT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CNOT3 VGNC VGNC:27518
Rattus norvegicus CNOT3 RGD RGD:1304771
Mus musculus CNOT3 MGD MGI:2385261
Macaca mulatta CNOT3 VGNC VGNC:71388
Canis familiaris CNOT3 VGNC VGNC:39414
Others CNOT3 NCBI