2. Gene
  3. CNOT6L - CCR4-NOT transcription complex subunit 6 like Gene

CNOT6L - CCR4-NOT transcription complex subunit 6 like Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CCR4b

Gene ID: 246175 | Gene type: protein coding

About CNOT6L

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:77,713,387-77,820,269 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 12.1), spleen (RPKM 8.9) and 25 other tissues.

Summary

Predicted to enable poly(A)-specific ribonuclease activity. Involved in positive regulation of cell population proliferation and positive regulation of cytoplasmic mRNA processing body assembly. Located in cytosol and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT6L Products(13)

mRNA Protein Name
NM_001286790.2 NP_001273719.1 CCR4-NOT transcription complex subunit 6-like isoform 1
NM_001365006.1 NP_001351935.1 CCR4-NOT transcription complex subunit 6-like isoform 2
NM_001365007.2 NP_001351936.1 CCR4-NOT transcription complex subunit 6-like isoform 2
NM_001387835.1 NP_001374764.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387836.1 NP_001374765.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387837.1 NP_001374766.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387838.1 NP_001374767.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387839.1 NP_001374768.1 CCR4-NOT transcription complex subunit 6-like isoform 4
NM_001387840.1 NP_001374769.1 CCR4-NOT transcription complex subunit 6-like isoform 4
NM_001387841.1 NP_001374770.1 CCR4-NOT transcription complex subunit 6-like isoform 5
NM_001387842.1 NP_001374771.1 CCR4-NOT transcription complex subunit 6-like isoform 6
NM_001387843.1 NP_001374772.1 CCR4-NOT transcription complex subunit 6-like isoform 6
NM_144571.3 NP_653172.2 CCR4-NOT transcription complex subunit 6-like isoform 1

CNOT6L Protein Structure

LRR_8

LRR_8: Leucine rich repeat (56 - 114)

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (192 - 529)

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  • 555 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 6-like

carbon catabolite repressor protein 4 homolog B

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02906 CNOT6L Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CNOT6L VGNC VGNC:39417
Felis catus CNOT6L VGNC VGNC:61029
Bos taurus CNOT6L VGNC VGNC:27521
Rattus norvegicus CNOT6L RGD RGD:1309128
Mus musculus CNOT6L MGD MGI:2443154
Macaca mulatta CNOT6L VGNC VGNC:100211