CNOT6L - CCR4-NOT transcription complex subunit 6 like Gene

Also Known as CCR4b

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 246175

About CNOT6L

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:77,713,387-77,820,269 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 12.1), spleen (RPKM 8.9) and 25 other tissues.

Summary

Predicted to enable poly(A)-specific ribonuclease activity. Involved in positive regulation of cell population proliferation and positive regulation of cytoplasmic mRNA processing body assembly. Located in cytosol and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT6L Products (13)

mRNA Protein Name
NM_001286790.2 NP_001273719.1 CCR4-NOT transcription complex subunit 6-like isoform 1
NM_001365006.1 NP_001351935.1 CCR4-NOT transcription complex subunit 6-like isoform 2
NM_001365007.2 NP_001351936.1 CCR4-NOT transcription complex subunit 6-like isoform 2
NM_001387835.1 NP_001374764.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387836.1 NP_001374765.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387837.1 NP_001374766.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387838.1 NP_001374767.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387839.1 NP_001374768.1 CCR4-NOT transcription complex subunit 6-like isoform 4
NM_001387840.1 NP_001374769.1 CCR4-NOT transcription complex subunit 6-like isoform 4
NM_001387841.1 NP_001374770.1 CCR4-NOT transcription complex subunit 6-like isoform 5
NM_001387842.1 NP_001374771.1 CCR4-NOT transcription complex subunit 6-like isoform 6
NM_001387843.1 NP_001374772.1 CCR4-NOT transcription complex subunit 6-like isoform 6
NM_144571.3 NP_653172.2 CCR4-NOT transcription complex subunit 6-like isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
17452450 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21233283 GOA
involved in positive regulation of cytoplasmic mRNA processing body assembly IMP
IMP: Inferred from mutant phenotype
21233283 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
19558367 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21233283 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21233283 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT6L Protein Structure

LRR_8

LRR_8: Leucine rich repeat (56 - 114)

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (192 - 529)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 555 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 6-like

  • carbon catabolite repressor protein 4 homolog B

CNOT6L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CNOT6L Q96LI5 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
33961781
Intra
CNOT6L Q96LI5 CNOT1 Homo sapiens A5YKK6
Anti Bait CoIP
21984185
Intra
CNOT6L Q96LI5 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
22977175
Intra
CNOT6L Q96LI5 TNKS1BP1 Homo sapiens Q9C0C2
Anti Tag CoIP
17452450
Intra
CNOT6L Q96LI5 TNKS1BP1 Homo sapiens Q9C0C2
Anti Tag CoIP
33961781
Intra
CNOT6L Q96LI5 CNOT7 Homo sapiens Q9UIV1
Anti Tag CoIP
33961781
Intra
CNOT6L Q96LI5 CNOT7 Homo sapiens Q9UIV1
Validated Y2H
32296183
Intra
CNOT6L Q96LI5 CNOT7 Homo sapiens Q9UIV1
Y2H Prey Pooling
32296183
Intra
CNOT6L Q96LI5 CNOT7 Homo sapiens Q9UIV1
Anti Bait CoIP
21984185
Intra
CNOT6L Q96LI5 CNOT7 Homo sapiens Q9UIV1
Y2H Array
32296183
Intra
CNOT6L Q96LI5 CNOT9 Homo sapiens Q92600
Anti Tag CoIP
33961781
Intra
CNOT6L Q96LI5 TOB1 Homo sapiens P50616
TAP
18377426
Intra
CNOT6L Q96LI5 TOB1 Homo sapiens P50616
Anti Tag CoIP
18377426
Intra
CNOT6L Q96LI5 CNOT8 Homo sapiens Q9UFF9
Validated Y2H
32296183
Intra
CNOT6L Q96LI5 CNOT8 Homo sapiens Q9UFF9
Anti Tag CoIP
33961781
Intra
CNOT6L Q96LI5 CNOT8 Homo sapiens Q9UFF9
Y2H Array
32296183
Intra
CNOT6L Q96LI5 CNOT8 Homo sapiens Q9UFF9
Y2H Prey Pooling
32296183
Intra
CNOT6L Q96LI5 CNOT2 Homo sapiens Q9NZN8
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02906 CNOT6L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CNOT6L VGNC VGNC:39417
Felis catus CNOT6L VGNC VGNC:61029
Bos taurus CNOT6L VGNC VGNC:27521
Rattus norvegicus CNOT6L RGD RGD:1309128
Mus musculus CNOT6L MGD MGI:2443154
Macaca mulatta CNOT6L VGNC VGNC:100211
Others CNOT6L NCBI