BTG2 - BTG anti-proliferation factor 2 Gene

Also Known as PC3; APRO1; TIS21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7832

About BTG2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,305,519-203,309,602 (from NCBI)

This gene has 2 transcripts (splice variants), 158 orthologues, 3 paralogues and is associated with 46 phenotypes. Ubiquitous expression in ovary (RPKM 185.2), esophagus (RPKM 183.2) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]

BTG2 Products (1)

mRNA	Protein	Name
NM_006763.3	NP_006754.1	protein BTG2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9712883	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	8944033	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23236473	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	23236473	GOA
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	18773938	GOA
acts upstream of or within positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	18337750	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTG2 Protein Structure

BTG

0
100
158 a.a.

Protein Preferred Names	Protein Names
protein BTG2	B-cell translocation gene 2

BTG2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	BTG2	P78543	Cnot7	Mus musculus	Q60809	Y2H	18337750
Cross	BTG2	P78543	Cnot7	Mus musculus	Q60809	Y2H	9712883
Intra	BTG2	P78543	CNOT7	Homo sapiens	Q9UIV1	Y2H Array	32296183
Intra	BTG2	P78543	CNOT7	Homo sapiens	Q9UIV1	Pull Down	11136725
Intra	BTG2	P78543	CNOT7	Homo sapiens	Q9UIV1	Y2H	11136725
Intra	BTG2	P78543	CNOT7	Homo sapiens	Q9UIV1	Y2H Prey Pooling	25416956
Intra	BTG2	P78543	CNOT7	Homo sapiens	Q9UIV1	Validated Y2H	25416956
Intra	BTG2	P78543	CNOT7	Homo sapiens	Q9UIV1	Y2H Prey Pooling	32296183
Intra	BTG2	P78543	CNOT7	Homo sapiens	Q9UIV1	Validated Y2H	32296183
Intra	BTG2	P78543	CNOT7	Homo sapiens	Q9UIV1	Y2H Array	25416956
Intra	BTG2	P78543	AR	Homo sapiens	P10275	Pull Down	21172304
Intra	BTG2	P78543	AR	Homo sapiens	P10275	Anti Bait CoIP	21172304
Intra	BTG2	P78543	CNOT8	Homo sapiens	Q9UFF9	Y2H Prey Pooling	25416956
Intra	BTG2	P78543	CNOT8	Homo sapiens	Q9UFF9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Diffuse Large B-Cell Lymphoma Activated B-Cell Type	Dlbcl Abc Type
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113455	9(S)-HODE	Inducer	98.0%	Unkown
HY-RS01663	BTG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20698	Btg2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27209	Btg2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BTG2	VGNC	VGNC:70288
Bos taurus	BTG2	VGNC	VGNC:26598
Rattus norvegicus	BTG2	RGD	RGD:2225
Felis catus	BTG2	VGNC	VGNC:107845
Mus musculus	BTG2	MGD	MGI:108384
Canis familiaris	BTG2	VGNC	VGNC:54278
Others	BTG2	NCBI