Cnot7 - CCR4-NOT transcription complex, subunit 7 Gene

Also Known as Caf1; Pop2; CAF-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18983

Summary

Enables poly(A)-specific ribonuclease activity. Involved in gene silencing by RNA; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Acts upstream of or within P-body assembly and positive regulation of RNA metabolic process. Located in P-body and nucleus. Part of CCR4-NOT complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and skeleton. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]

Cnot7 Products (5)

mRNA	Protein	Name
NM_001271542.1	NP_001258471.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001271543.1	NP_001258472.1	CCR4-NOT transcription complex subunit 7 isoform 2
NM_001361938.1	NP_001348867.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001361939.1	NP_001348868.1	CCR4-NOT transcription complex subunit 7 isoform 3
NM_011135.5	NP_035265.1	CCR4-NOT transcription complex subunit 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables piRNA binding	IDA IDA: Inferred from direct assay	24787618	MGI
enables poly(A)-specific ribonuclease activity	IMP IMP: Inferred from mutant phenotype	18625844	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9712883	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within P-body assembly	IGI IGI: Inferred from genetic interaction	18625844	MGI
acts upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA	IGI IGI: Inferred from genetic interaction	18625844	MGI
acts upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA	IMP IMP: Inferred from mutant phenotype	18625844	MGI
acts upstream of or within nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: Inferred from mutant phenotype	18625844	MGI
involved in piRNA-mediated gene silencing by mRNA destabilization	IPI IPI: Inferred from physical interaction	24787618	MGI
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP IMP: Inferred from mutant phenotype	19716330	MGI
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: Inferred from mutant phenotype	19716330	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7791755	MGI
involved in regulatory ncRNA-mediated gene silencing	IMP IMP: Inferred from mutant phenotype	19716330	MGI
involved in spermatogenesis	EXP EXP: Inferred from Experiment	24787618	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of CCR4-NOT complex	IPI IPI: Inferred from physical interaction	7791755	MGI
located in P-body	IDA IDA: Inferred from direct assay	18625844	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	18625844	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18625844	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
CCR4-NOT transcription complex subunit 7	CCR4-associated factor 1 POP2 homolog catabolite repressor protein (CCR4)-associative factor 1

Cnot7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Cnot7	Q60809	BTG2	Homo sapiens	P78543	Pull Down	9712883
Cross	Cnot7	Q60809	BTG2	Homo sapiens	P78543	Y2H	9712883
Intra	Cnot7	Q60809	Btg4	Mus musculus	O70552	Anti Tag CoIP	27065194
Intra	Cnot7	Q60809	Cnot6l	Mus musculus	Q8VEG6	Anti Bait CoIP	21897366
Cross	Cnot7	Q60809	CNOT11	Homo sapiens	Q9UKZ1	Pull Down	23232451
Cross	Cnot7	Q60809	CNOT11	Homo sapiens	Q9UKZ1	TAP	23232451
Cross	Cnot7	Q60809	EIF4E	Homo sapiens	P06730	Anti Tag CoIP	27065194
Cross	Cnot7	Q60809	BTG1	Homo sapiens	P62324	Y2H	9712883
Intra	Cnot7	Q60809	Btg2	Mus musculus	Q04211	Pull Down	18337750

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02907	CNOT7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22451	Cnot7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28974	Cnot7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cnot7	NCBI	NCBI:29883