Cnot6l - CCR4-NOT transcription complex, subunit 6-like Gene

Also Known as 4932442K20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231464

Summary

Enables poly(A)-specific ribonuclease activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and positive regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and white fat. Orthologous to human CNOT6L (CCR4-NOT transcription complex subunit 6 like). [provided by Alliance of Genome Resources, Apr 2022]

Cnot6l Products (4)

mRNA Protein Name
NM_001285511.1 NP_001272440.1 CCR4-NOT transcription complex subunit 6-like isoform 1
NM_001285514.1 NP_001272443.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_144910.2 NP_659159.1 CCR4-NOT transcription complex subunit 6-like isoform 1
NM_178854.4 NP_849185.2 CCR4-NOT transcription complex subunit 6-like isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables poly(A)-specific ribonuclease activity IMP
IMP: Inferred from mutant phenotype
17452450 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17452450 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within mRNA destabilization IMP
IMP: Inferred from mutant phenotype
17452450 MGI
acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
IMP: Inferred from mutant phenotype
17452450 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17452450 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17452450 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 6-like

Cnot6l Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cnot6l Q8VEG6 Cnot7 Mus musculus Q60809
Anti Bait CoIP
17452450
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02906 CNOT6L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cnot6l NCBI NCBI:246175