CNOT10 - CCR4-NOT transcription complex subunit 10 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25904

About CNOT10

This gene has 18 transcripts (splice variants) and 209 orthologues. Broad expression in testis (RPKM 18.8), thyroid (RPKM 7.6) and 24 other tissues.

Summary

Predicted to be involved in mRNA catabolic process and negative regulation of translation. Located in membrane. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT10 Products (7)

mRNA Protein Name
NM_001256741.2 NP_001243670.1 CCR4-NOT transcription complex subunit 10 isoform 2
NM_001256742.2 NP_001243671.1 CCR4-NOT transcription complex subunit 10 isoform 3
NM_001393366.1 NP_001380295.1 CCR4-NOT transcription complex subunit 10 isoform 4
NM_001393367.1 NP_001380296.1 CCR4-NOT transcription complex subunit 10 isoform 5
NM_001393368.1 NP_001380297.1 CCR4-NOT transcription complex subunit 10 isoform 6
NM_001393369.1 NP_001380298.1 CCR4-NOT transcription complex subunit 10 isoform 7
NM_015442.3 NP_056257.1 CCR4-NOT transcription complex subunit 10 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17452450 GOA
Cellular Component GO Annotation Evidence References Source
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
19558367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT10 Protein Structure

TPR_1

TPR_1: Tetratricopeptide repeat (296 - 324)

TPR_1

TPR_1: Tetratricopeptide repeat (646 - 669)

  • 0
  • 200
  • 400
  • 600
  • 744 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 10

CNOT10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CNOT10 Q9H9A5 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
33961781
Intra
CNOT10 Q9H9A5 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
17452450
Intra
CNOT10 Q9H9A5 CNOT6 Homo sapiens Q9ULM6
Anti Tag CoIP
33961781
Intra
CNOT10 Q9H9A5 CNOT11 Homo sapiens Q9UKZ1
Y2H
23232451
Intra
CNOT10 Q9H9A5 CNOT11 Homo sapiens Q9UKZ1
Anti Tag CoIP
33961781
Intra
CNOT10 Q9H9A5 CNOT11 Homo sapiens Q9UKZ1
Pull Down
23232451
Intra
CNOT10 Q9H9A5 TOB1 Homo sapiens P50616
TAP
18377426
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mayer-Rokitansky-Kuster-Hauser Syndrome Type 1

  • Rokitansky Sequence

  • Congenital Absence Of Uterus And Vagina

  • Mrkh Syndrome Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02900 CNOT10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CNOT10 VGNC VGNC:27515
Canis familiaris CNOT10 VGNC VGNC:39411
Rattus norvegicus CNOT10 RGD RGD:1359219
Mus musculus CNOT10 MGD MGI:1926143
Felis catus CNOT10 VGNC VGNC:61026
Macaca mulatta CNOT10 VGNC VGNC:71327
Others CNOT10 NCBI