IPO8 - importin 8 Gene

Also Known as VISS; RANBP8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10526

About IPO8

Cytogenetic location: 12p11.21 Genomic coordinates (GRCh38): 12:30,628,988-30,695,869 (from NCBI)

This gene has 11 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 11.8), testis (RPKM 10.7) and 25 other tissues.

Summary

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

IPO8 Products (2)

mRNA	Protein	Name
NM_001190995.2	NP_001177924.1	importin-8 isoform 2
NM_006390.4	NP_006381.2	importin-8 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17785517	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IPO8 Protein Structure

IBN_N

Cse1

0
200
400
600
800
1037 a.a.

Protein Preferred Names	Protein Names
importin-8	RAN binding protein 8

IPO8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IPO8	O15397	ZNF774	Homo sapiens	Q6NX45	Validated Y2H	32296183
Intra	IPO8	O15397	ZNF331	Homo sapiens	Q9NQX6	Anti Tag CoIP	26496610
Intra	IPO8	O15397	AGO3	Homo sapiens	Q9H9G7	Anti Tag CoIP	19167051
Intra	IPO8	O15397	AGO3	Homo sapiens	Q9H9G7	Confocal	19167051
Intra	IPO8	O15397	AGO4	Homo sapiens	Q9HCK5	Anti Tag CoIP	19167051
Intra	IPO8	O15397	AGO4	Homo sapiens	Q9HCK5	Pull Down	19167051
Intra	IPO8	O15397	ZNF264	Homo sapiens	O43296	Validated Y2H	32296183
Intra	IPO8	O15397	AGO1	Homo sapiens	Q9UL18	Anti Tag CoIP	19167051
Intra	IPO8	O15397	AGO1	Homo sapiens	Q9UL18	Pull Down	19167051
Intra	IPO8	O15397	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	19167051
Intra	IPO8	O15397	AGO2	Homo sapiens	Q9UKV8	Pull Down	19167051
Intra	IPO8	O15397	ZFP2	Homo sapiens	Q6ZN57	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Viss Syndrome	VISS Vascular Aneurysm, Immune Dysregulation, Skeletal Anomalies, And Skin And Joint Laxity
Aortic Aneurysm	Aortic Rupture Thoracoabdominal Aortic Aneurysm, Ruptured Ruptured Aortic Aneurysm Aortic Aneurysms Aortic Aneurysm Without Mention Of Rupture Nos Ruptured Abdominal Aortic Aneurysm Aortic Aneurysm, Ruptured Ruptured Thoracic Aortic Aneurysm
Autosomal Recessive Nonsyndromic Deafness 32	Deafness, Autosomal Recessive 32 Autosomal Recessive Deafness 105 Autosomal Recessive Deafness 32 Dfnb32 Hearing Impairment Infertile Male Syndrome Hiims Deafness, Autosomal Recessive, Type 32

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06871	IPO8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IPO8	VGNC	VGNC:73815
Mus musculus	IPO8	MGD	MGI:2444611
Bos taurus	IPO8	VGNC	VGNC:30245
Felis catus	IPO8	VGNC	VGNC:69234
Canis familiaris	IPO8	VGNC	VGNC:42068
Rattus norvegicus	IPO8	RGD	RGD:1593688
Others	IPO8	NCBI