IPO8 - importin 8 Gene

Homo sapiens

Also known as VISS; RANBP8

Gene ID: 10526 | Gene type: protein coding

About IPO8

Cytogenetic location: 12p11.21 Genomic coordinates (GRCh38): 12:30,628,988-30,695,869 (from NCBI)

This gene has 11 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 11.8), testis (RPKM 10.7) and 25 other tissues.

Summary

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

IPO8 Products(2)

mRNA	Protein	Name
NM_001190995.2	NP_001177924.1	importin-8 isoform 2
NM_006390.4	NP_006381.2	importin-8 isoform 1

IPO8 Protein Structure

IBN_N

Cse1

0
200
400
600
800
1037 a.a.

Protein Preferred Names

Protein Names

importin-8

RAN binding protein 8

Related Diseases

Diseases

Alias

Viss Syndrome

VISS	Vascular Aneurysm, Immune Dysregulation, Skeletal Anomalies, And Skin And Joint Laxity

Aortic Aneurysm

Aortic Rupture	Thoracoabdominal Aortic Aneurysm, Ruptured
Ruptured Aortic Aneurysm	Aortic Aneurysms
Aortic Aneurysm Without Mention Of Rupture Nos	Ruptured Abdominal Aortic Aneurysm
Aortic Aneurysm, Ruptured	Ruptured Thoracic Aortic Aneurysm

Autosomal Recessive Nonsyndromic Deafness 32

Deafness, Autosomal Recessive 32	Autosomal Recessive Deafness 105
Autosomal Recessive Deafness 32	Dfnb32
Hearing Impairment Infertile Male Syndrome	Hiims
Deafness, Autosomal Recessive, Type 32

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06871	IPO8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IPO8	VGNC	VGNC:73815
Mus musculus	IPO8	MGD	MGI:2444611
Bos taurus	IPO8	VGNC	VGNC:30245
Felis catus	IPO8	VGNC	VGNC:69234
Canis familiaris	IPO8	VGNC	VGNC:42068
Rattus norvegicus	IPO8	RGD	RGD:1593688