ZNF331 - zinc finger protein 331 Gene

Also Known as RITA; ZNF361; ZNF463

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55422

About ZNF331

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:53,503,235-53,580,269 (from NCBI)

This gene has 28 transcripts (splice variants), 67 orthologues, 174 paralogues and is associated with 75 phenotypes. Broad expression in adrenal (RPKM 22.0), placenta (RPKM 9.5) and 20 other tissues.

Summary

This gene encodes a Zinc Finger Protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in Cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015]

ZNF331 Products (16)

mRNA Protein Name
NM_001079906.2 NP_001073375.1 zinc finger protein 331
NM_001079907.1 NP_001073376.1 zinc finger protein 331
NM_001253798.2 NP_001240727.1 zinc finger protein 331
NM_001253799.2 NP_001240728.1 zinc finger protein 331
NM_001253800.3 NP_001240729.1 zinc finger protein 331
NM_001253801.2 NP_001240730.1 zinc finger protein 331
NM_001317113.2 NP_001304042.1 zinc finger protein 331
NM_001317114.2 NP_001304043.1 zinc finger protein 331
NM_001317115.2 NP_001304044.1 zinc finger protein 331
NM_001317116.2 NP_001304045.1 zinc finger protein 331
NM_001317117.1 NP_001304046.1 zinc finger protein 331
NM_001317118.1 NP_001304047.1 zinc finger protein 331
NM_001317119.1 NP_001304048.1 zinc finger protein 331
NM_001317120.2 NP_001304049.1 zinc finger protein 331
NM_001317121.1 NP_001304050.1 zinc finger protein 331
NM_018555.6 NP_061025.5 zinc finger protein 331

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26496610 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF331 Protein Structure

KRAB

KRAB: KRAB box (6 - 46)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (146 - 168)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (174 - 196)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (201 - 225)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (230 - 254)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (260 - 280)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (286 - 310)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (314 - 336)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (341 - 365)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (369 - 392)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (397 - 422)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (426 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 463 a.a.
Protein Preferred Names Protein Names

zinc finger protein 331

  • C2H2-like zinc finger protein rearranged in thyroid adenomas

ZNF331 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF331 Q9NQX6 IPO8 Homo sapiens O15397
Anti Tag CoIP
33961781
Intra
ZNF331 Q9NQX6 IPO8 Homo sapiens O15397
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16126 ZNF331 Human Pre-designed siRNA Set A Pre-designed Set / Unkown