GSPT2 - G1 to S phase transition 2 Gene

Also Known as GST2; ERF3B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23708

About GSPT2

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:51,743,442-51,746,232 (from NCBI)

This gene has 1 transcript (splice variant), 80 orthologues, 18 paralogues and is associated with 1 phenotype.

Summary

This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]

GSPT2 Products (1)

mRNA	Protein	Name
NM_018094.5	NP_060564.2	eukaryotic peptide chain release factor GTP-binding subunit ERF3B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	15987998	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9712840	GOA
enables translation release factor activity	IDA IDA: Inferred from direct assay	15987998	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in translational termination	IDA IDA: Inferred from direct assay	15987998	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSPT2 Protein Structure

PAM2

GTP_EFTU

GTP_EFTU_D2

GTP_EFTU_D3

0
100
200
300
400
500
628 a.a.

Protein Preferred Names	Protein Names
eukaryotic peptide chain release factor GTP-binding subunit ERF3B	eukaryotic peptide chain release factor subunit 3b

GSPT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GSPT2	Q8IYD1	UPF1	Homo sapiens	Q92900	Anti Bait CoIP	18447585
Intra	GSPT2	Q8IYD1	UPF1	Homo sapiens	Q92900	Anti Tag CoIP	33961781
Intra	GSPT2	Q8IYD1	ETF1	Homo sapiens	P62495	Anti Tag CoIP	33961781
Intra	GSPT2	Q8IYD1	ETF1	Homo sapiens	P62495	Anti Tag CoIP	28514442
Intra	GSPT2	Q8IYD1	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	23340509
Intra	GSPT2	Q8IYD1	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	33961781
Intra	GSPT2	Q8IYD1	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	18447585
Intra	GSPT2	Q8IYD1	PABPC1	Homo sapiens	P11940	ITC	14685257
Intra	GSPT2	Q8IYD1	PABPC1	Homo sapiens	P11940	Anti Bait CoIP	18447585
Intra	GSPT2	Q8IYD1	PABPC1	Homo sapiens	P11940	Pull Down	18447585

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Treacher Collins Syndrome 3	TCS3 Mandibulofacial Dysostosis, Treacher Collins Type, Autosomal Recessive Mandibulofacial Dysostosis Treacher Collins Type Autosomal Recessive
Leukodystrophy, Hypomyelinating, 11	Hypomyelinating Leukodystrophy 11 HLD11 4h Leukodystrophy 3 Leukodystrophy, Hypomyelinating, Type 11
Chromosome Xp11.22 Duplication Syndrome	Mrx17 Mental Retardation, X-Linked 31 Mrx31 Xp11.22 Microduplication Syndrome X-Linked Mental Retardation 31 Mental Retardation, X-Linked 17
Brugada Syndrome 5	BRGDA5 Cardiac Conduction Defect, Nonspecific Brugada Syndrome, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148837	GT19630		98.85%	Unkown
HY-150259	MDEG-541	Degrader	98.68%	Unkown
HY-161101	MG degrader 1	Degrader	99.30%	Unkown
HY-172770	KMG-1068		99.73%	Unkown
HY-177744	GSPT2 degrader-1		/	Unkown
HY-RS05869	GSPT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-177777	FL2-14		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GSPT2	MGD	MGI:1316727
Rattus norvegicus	GSPT2	RGD	RGD:1563213
Bos taurus	GSPT2	VGNC	VGNC:106763
Others	GSPT2	NCBI