MG degrader 1
Based on 1 Customer Validation
MG degrader 1 (Compd E14) is a PROTAC degrader of IKZF3, GSPT1, and GSPT2 with an EC50 value of 1.385 nM in MM.1S cells.
For research use only. We do not sell to patients.
- Purity: 99.30%
- Formula: C31H37N5O7
- Molecular Weight:591.65
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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IKZF3 1.385 nM (EC50) |
Chemical Information
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Appearance Solid
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Molecular Weight 591.65
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Formula C31H37N5O7
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Color Light yellow to yellow
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SMILES
O=C1N(C2CCC(NC2=O)=O)C(C3=C(NCCCCNC(C(C4=CC=CC(OC)=C4)N(CC(C)C)C=O)=O)C=CC=C31)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (211.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6902 mL | 8.4509 mL | 16.9019 mL | 42.2547 mL |
| 5 mM | 0.3380 mL | 1.6902 mL | 3.3804 mL | 8.4509 mL | |
| 10 mM | 0.1690 mL | 0.8451 mL | 1.6902 mL | 4.2255 mL | |
| 15 mM | 0.1127 mL | 0.5634 mL | 1.1268 mL | 2.8170 mL | |
| 20 mM | 0.0845 mL | 0.4225 mL | 0.8451 mL | 2.1127 mL | |
| 25 mM | 0.0676 mL | 0.3380 mL | 0.6761 mL | 1.6902 mL | |
| 30 mM | 0.0563 mL | 0.2817 mL | 0.5634 mL | 1.4085 mL | |
| 40 mM | 0.0423 mL | 0.2113 mL | 0.4225 mL | 1.0564 mL | |
| 50 mM | 0.0338 mL | 0.1690 mL | 0.3380 mL | 0.8451 mL | |
| 60 mM | 0.0282 mL | 0.1408 mL | 0.2817 mL | 0.7042 mL | |
| 80 mM | 0.0211 mL | 0.1056 mL | 0.2113 mL | 0.5282 mL | |
| 100 mM | 0.0169 mL | 0.0845 mL | 0.1690 mL | 0.4225 mL |
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