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SJ6986 

Cat. No.: HY-132199
Handling Instructions

SJ6986 is a potent, selective and orally active GSPT1/2 degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1.

For research use only. We do not sell to patients.

SJ6986 Chemical Structure

SJ6986 Chemical Structure

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Description

SJ6986 is a potent, selective and orally active GSPT1/2 degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1[1].

IC50 & Target

DC50: 2.1 nM (GSPT1)[1].

In Vitro

SJ6986 exhibits EC50 values of 1.5 nM, 0.4 nM, 726 nM, 336 nM and 3583 nM in MV4-11, MHH-CALL-4, MB002, MB004 and HD-MB03 cell lines, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MV4-11 cells.
Concentration: 0-100 μM.
Incubation Time: 3 days.
Result: Exhibited EC50 of 1.5 nM.

Western Blot Analysis[1]

Cell Line: MV4-11 cells.
Concentration: 0-10 μM.
Incubation Time: 4 and 24 h.
Result: Dose- and time-dependently decreased the protein levels of GSPT1.
In Vivo

SJ6986 exhibits t1/2 of 3.44 h by iv injection of 3 mg/kg and tmax of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

497.40

Formula

C₂₀H₁₄F₃N₃O₇S

SMILES

O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SJ6986SJ 6986SJ-6986OthersGSPTLeukemiaCRBNInhibitorinhibitorinhibit

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SJ6986
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