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LARP4B - La ribonucleoprotein 4B Gene

Also Known as LARP5; KIAA0217

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23185

About LARP4B

Cytogenetic location: 10p15.3 Genomic coordinates (GRCh38): 10:806,914-988,341 (from NCBI)

This gene has 17 transcripts (splice variants), 268 orthologues, 6 paralogues and is associated with 70 phenotypes. Ubiquitous expression in thyroid (RPKM 6.7), testis (RPKM 6.0) and 25 other tissues.

Summary

This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]

LARP4B Products (2)

mRNA	Protein	Name
NM_001351277.2	NP_001338206.1	la-related protein 4B isoform 2
NM_015155.3	NP_055970.1	la-related protein 4B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	26001795	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of 3'-UTR-mediated mRNA stabilization	IMP IMP: Inferred from mutant phenotype	26001795	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	20573744	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	20573744	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20573744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LARP4B Protein Structure

0
200
400
600
738 a.a.

Protein Preferred Names	Protein Names
la-related protein 4B	La ribonucleoprotein domain family member 4B

LARP4B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LARP4B	Q92615	SARS1	Homo sapiens	P49591	Validated Y2H	32814053
Intra	LARP4B	Q92615	SARS1	Homo sapiens	P49591	Y2H Array	32814053
Intra	LARP4B	Q92615	SARS1	Homo sapiens	P49591	Y2H Pooling	32814053
Intra	LARP4B	Q92615	EIF2S3	Homo sapiens	P41091	Validated Y2H	32814053
Intra	LARP4B	Q92615	EIF2S3	Homo sapiens	P41091	Y2H Array	32814053
Intra	LARP4B	Q92615	EIF2S3	Homo sapiens	P41091	Y2H Pooling	32814053
Intra	LARP4B	Q92615	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	LARP4B	Q92615	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	LARP4B	Q92615	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	LARP4B	Q92615	BACE2	Homo sapiens	Q9Y5Z0	Y2H Array	32814053
Intra	LARP4B	Q92615	BACE2	Homo sapiens	Q9Y5Z0	Y2H Pooling	32814053
Intra	LARP4B	Q92615	BACE2	Homo sapiens	Q9Y5Z0	Validated Y2H	32814053
Intra	LARP4B	Q92615	ERN1	Homo sapiens	O75460-2	Y2H Pooling	32814053
Intra	LARP4B	Q92615	ERN1	Homo sapiens	O75460-2	Validated Y2H	32814053
Intra	LARP4B	Q92615	ERN1	Homo sapiens	O75460-2	Y2H Array	32814053
Intra	LARP4B	Q92615	RACK1	Homo sapiens	P63244	Anti Tag CoIP	33961781
Intra	LARP4B	Q92615	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	LARP4B	Q92615	F11R	Homo sapiens	Q9Y624	Validated Y2H	32814053
Intra	LARP4B	Q92615	F11R	Homo sapiens	Q9Y624	Y2H Pooling	32814053
Intra	LARP4B	Q92615	F11R	Homo sapiens	Q9Y624	Y2H Array	32814053
Intra	LARP4B	Q92615	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	33961781
Intra	LARP4B	Q92615	e9kl35_human	Homo sapiens	E9KL35	Y2H Prey Pooling	25416956
Intra	LARP4B	Q92615	e9kl35_human	Homo sapiens	E9KL35	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nephronophthisis 3	NPHP3 Nph3 Adolescent Nephronophthisis Nephronophthisis, Type 3
Hypoparathyroidism-Deafness-Renal Disease Syndrome	Barakat Syndrome Hypoparathyroidism, Deafness, Renal Disease Syndrome Hdr Syndrome Hypoparathyroidism, Sensorineural Deafness, And Renal Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07529	LARP4B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LARP4B	RGD	RGD:1310713
Felis catus	LARP4B	VGNC	VGNC:63194
Bos taurus	LARP4B	VGNC	VGNC:30792
Mus musculus	LARP4B	MGD	MGI:106330
Macaca mulatta	LARP4B	VGNC	VGNC:74153
Others	LARP4B	NCBI