PAIP2 - poly(A) binding protein interacting protein 2 Gene

Also Known as PAIP-2; PAIP2A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51247

About PAIP2

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,341,854-139,369,717 (from NCBI)

This gene has 8 transcripts (splice variants), 192 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 45.2), adrenal (RPKM 41.5) and 25 other tissues.

Summary

Enables translation repressor activity. Involved in negative regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PAIP2 Products (2)

mRNA Protein Name
NM_001033112.3 NP_001028284.1 polyadenylate-binding protein-interacting protein 2
NM_016480.5 NP_057564.3 polyadenylate-binding protein-interacting protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11172725 GOA
enables translation repressor activity IDA
IDA: Inferred from direct assay
11172725 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of translational initiation IDA
IDA: Inferred from direct assay
11172725 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11172725 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAIP2 Protein Structure

PAM2

PAM2: Ataxin-2 C-terminal region (108 - 123)

  • 0
  • 100
  • 127 a.a.
Protein Preferred Names Protein Names

polyadenylate-binding protein-interacting protein 2

  • PABC1-interacting protein 2

PAIP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAIP2 Q9BPZ3 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32814053
Intra
PAIP2 Q9BPZ3 NUP58 Homo sapiens Q9BVL2
Y2H Array
32814053
Intra
PAIP2 Q9BPZ3 NUP58 Homo sapiens Q9BVL2
Y2H Pooling
32814053
Intra
PAIP2 Q9BPZ3 UBR5 Homo sapiens O95071
Enzymatic Study
16601676
Intra
PAIP2 Q9BPZ3 UBR5 Homo sapiens O95071
NMR
16601676
Intra
PAIP2 Q9BPZ3 UBR5 Homo sapiens O95071
Anti Bait CoIP
16601676
Intra
PAIP2 Q9BPZ3 NDN Homo sapiens Q99608
Anti Tag CoIP
32529326
Intra
PAIP2 Q9BPZ3 PABPC1 Homo sapiens P11940
Anti Tag CoIP
35511136
Intra
PAIP2 Q9BPZ3 PABPC1 Homo sapiens P11940
SPR
14685257
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myoclonic Epilepsy, Juvenile 3

  • Myoclonic Epilepsy, Juvenile, Susceptibility To, 3

  • EJM3

  • Epilepsy, Juvenile Myoclonic 3

  • Juvenile Myoclonic Epilepsy 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09982 PAIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PAIP2 MGD MGI:1915119
Rattus norvegicus PAIP2 RGD RGD:1359176
Bos taurus PAIP2 VGNC VGNC:53573
Felis catus PAIP2 VGNC VGNC:102278
Macaca mulatta PAIP2 VGNC VGNC:110446
Others PAIP2 NCBI