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4EGI-1 

Cat. No.: HY-19831 Purity: >98.0%
Data Sheet SDS Handling Instructions

4EGI-1 is an inhibitor of the cap-dependent translation initiation through disturbing the interaction between eIF4E and eIF4G, HNE1 cell line is the most sensitive one to 4EGI-1, and the IC50 of 4EGI-1 was about 50μM at 72h.

For research use only. We do not sell to patients.
4EGI-1 Chemical Structure

4EGI-1 Chemical Structure

CAS No. : 315706-13-9

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10 mM * 1 mL in DMSO $99 In-stock
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10 mg $120 In-stock
25 mg $220 In-stock
50 mg $350 In-stock
100 mg $560 In-stock
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Customer Review

    4EGI-1 purchased from MCE. Usage Cited in: Nat Commun. 2017 Jun 8;8:15617.

    Immunoblot analysis of KRAS protein levels in parental (P) and resistant derivatives (R1 and R2) following 4 h treatment with the corresponding inhibitors Rapamycin, AZD2014, MLN0128, BEZ235 and 4EGI-1. Images are cropped for clarity from the same exposure of the same membrane.

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    Description

    4EGI-1 is an inhibitor of the cap-dependent translation initiation through disturbing the interaction between eIF4E and eIF4G, HNE1 cell line is the most sensitive one to 4EGI-1, and the IC50 of 4EGI-1 was about 50μM at 72h. IC50 value: 50μM (72h, for HNE1 cell) [1] Target: eIF4E/eIF4G in vitro: 4EGI-1 induces apoptosis in NPC cells through the DR5-caspase-8 axis on 4E-BP1 and eIF4E dephosphorylation exerting positive influence on their anti-tumor activities. 4EGI-1 inhibits proliferation and induces apoptosis in human NPC cell lines. 4EGI-1 induces apoptosis in NPC cell line via DR5 induction on 4E-BP1 dephosphorylation. GI-1 sensitizes NPC cell line to radiation therapy through upregulating expression of DR5. [1] The eIF4E/eIF4G interaction inhibitor 1 (4EGI-1) dissociates eIF4G but enhances 4E-BP1 binding and has antitumor activity. The eIF4E/eIF4G interaction inhibitor 1 (4EGI-1) disrupts the eIF4E/eIF4G interaction and promotes binding of 4E-BP1 to eIF4E. [2]

    References
    Molecular Weight

    451.28

    Formula

    C₁₈H₁₂Cl₂N₄O₄S

    CAS No.

    315706-13-9

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    DMSO: ≥ 35 mg/mL

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    4EGI-1
    Cat. No.:
    HY-19831
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