1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)
  3. (Z)-4EGI-1

(Z)-4EGI-1 

Cat. No.: HY-19831A Purity: 98.01%
Handling Instructions

(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity.

For research use only. We do not sell to patients.

(Z)-4EGI-1 Chemical Structure

(Z)-4EGI-1 Chemical Structure

CAS No. : 901787-88-0

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Based on 1 publication(s) in Google Scholar

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Description

(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2].

IC50 & Target

IC50: 43.5 μM (eIF4E)[2]
Kd: 8.74 μM (eIF4E)[1]

In Vitro

(Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected[1].
(Z)-4EGI-1 inhibits cancer cells proliferation with IC50 values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively[2].

Western Blot Analysis[1]

Cell Line: CRL-2813 melanoma cells
Concentration: 15 µM, 30 µM
Incubation Time: 6 hours
Result: Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin.
Molecular Weight

451.28

Formula

C₁₈H₁₂Cl₂N₄O₄S

CAS No.

901787-88-0

SMILES

O=C(O)/C(CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(C3=CC=C(Cl)C(Cl)=C3)=CS2.[(Z)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (110.80 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2159 mL 11.0796 mL 22.1592 mL
5 mM 0.4432 mL 2.2159 mL 4.4318 mL
10 mM 0.2216 mL 1.1080 mL 2.2159 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(Z)-4EGI-1Eukaryotic Initiation Factor (eIF)Protein-proteininteractioneIF4EeIF4GtranslationZ-isomerhydrophobicitycyclin D1cyclin ESurvivinanti-proliferationInhibitorinhibitorinhibit

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Product name:
(Z)-4EGI-1
Cat. No.:
HY-19831A
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