TDO2 - tryptophan 2,3-dioxygenase Gene

Also Known as TO; TDO; TPH2; TRPO; HYPTRP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6999

About TDO2

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,903,696-155,920,406 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 223 orthologues and is associated with 2 phenotypes. Biased expression in liver (RPKM 202.8) and appendix (RPKM 14.2).

Summary

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in Cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

TDO2 Products (1)

mRNA Protein Name
NM_005651.4 NP_005642.1 tryptophan 2,3-dioxygenase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables heme binding IDA
IDA: Inferred from direct assay
27762317 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
24722188 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables tryptophan 2,3-dioxygenase activity IDA
IDA: Inferred from direct assay
27762317 GOA
Biological Process GO Annotation Evidence References Source
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
27762317 GOA
involved in tryptophan catabolic process to kynurenine IDA
IDA: Inferred from direct assay
27762317 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TDO2 Protein Structure

Trp_dioxygenase

Trp_dioxygenase: Tryptophan 2,3-dioxygenase (27 - 372)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

tryptophan 2,3-dioxygenase

  • tryptamin 2,3-dioxygenase

TDO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TDO2 P48775 NGB Homo sapiens Q9NPG2
Validated Y2H
32296183
Intra
TDO2 P48775 NGB Homo sapiens Q9NPG2
Y2H Array
25416956
Intra
TDO2 P48775 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
TDO2 P48775 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
TDO2 P48775 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
TDO2 P48775 PM20D2 Homo sapiens Q8IYS1
Validated Y2H
32296183
Intra
TDO2 P48775 AHCYL1 Homo sapiens O43865
Validated Y2H
32814053
Intra
TDO2 P48775 AHCYL1 Homo sapiens O43865
Y2H Pooling
32814053
Intra
TDO2 P48775 AHCYL1 Homo sapiens O43865
Y2H Array
32814053
Intra
TDO2 P48775 NR1D1 Homo sapiens P20393
Y2H Array
32296183
Intra
TDO2 P48775 NR1D1 Homo sapiens P20393
Y2H Prey Pooling
32296183
Intra
TDO2 P48775 NMNAT1 Homo sapiens Q9HAN9
Validated Y2H
32296183
Intra
TDO2 P48775 NMNAT1 Homo sapiens Q9HAN9
Y2H Array
32296183
Intra
TDO2 P48775 NMNAT1 Homo sapiens Q9HAN9
Y2H Prey Pooling
32296183
Intra
TDO2 P48775 NMNAT1 Homo sapiens Q9HAN9
Y2H Array
24722188
Intra
TDO2 P48775 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
TDO2 P48775 SDCBP Homo sapiens O00560
Y2H Array
24722188
Intra
TDO2 P48775 CDH1 Homo sapiens P12830
Y2H Array
32814053
Intra
TDO2 P48775 CDH1 Homo sapiens P12830
Y2H Pooling
32814053
Intra
TDO2 P48775 CDH1 Homo sapiens P12830
Validated Y2H
32814053
Intra
TDO2 P48775 EIF4E Homo sapiens P06730
Y2H Prey Pooling
25416956
Intra
TDO2 P48775 EIF4E Homo sapiens P06730
Validated Y2H
25416956
Intra
TDO2 P48775 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TDO2 P48775 SDCBP2 Homo sapiens Q9H190
Y2H Array
31515488
Intra
TDO2 P48775 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
25416956
Intra
TDO2 P48775 SDCBP2 Homo sapiens Q9H190
Validated Y2H
25416956
Intra
TDO2 P48775 SDCBP2 Homo sapiens Q9H190
Y2H Array
25416956
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Anti Tag CoIP
33961781
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Validated Y2H
25416956
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Anti Tag CoIP
28514442
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Y2H Array
25416956
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Y2H Prey Pooling
32296183
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Y2H Array
32296183
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Y2H Array
24722188
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Y2H Pooling
16189514
Intra
TDO2 P48775 TDO2 Homo sapiens P48775
Y2H Array
32296183
Intra
TDO2 P48775 TDO2 Homo sapiens P48775
Y2H Prey Pooling
32296183
Intra
TDO2 P48775 TDO2 Homo sapiens P48775
Y2H Array
24722188
Intra
TDO2 P48775 TDO2 Homo sapiens P48775
Validated Y2H
32296183
Intra
TDO2 P48775 TDO2 Homo sapiens P48775
Y2H Array
25416956
Intra
TDO2 P48775 MOB1A Homo sapiens Q9H8S9
Validated Y2H
32296183
Intra
TDO2 P48775 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
TDO2 P48775 ZFYVE26 Homo sapiens Q68DK2-5
Y2H Prey Pooling
25416956
Intra
TDO2 P48775 ZFYVE26 Homo sapiens Q68DK2-5
Validated Y2H
25416956
Intra
TDO2 P48775 ZFYVE26 Homo sapiens Q68DK2-5
Validated Y2H
32296183
Intra
TDO2 P48775 MOB3C Homo sapiens Q70IA8
Validated Y2H
25416956
Intra
TDO2 P48775 MOB3C Homo sapiens Q70IA8
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypertryptophanemia

  • HYPTRP

  • Hypertryptophanemia, Familial

  • Familial Hypertryptophanemia
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Constipation
Schizophrenia 12

  • Sczd12

  • Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Acute Porphyria

  • Porphyrias, Hepatic

  • Hepatic Porphyria

  • Porphyria Hepatic

  • Acute Intermittent Porphyria
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Variegate Porphyria

  • Porphyria Variegata

  • Protoporphyrinogen Oxidase Deficiency

  • VP

  • Ppox Deficiency

  • Porphyria, South African Type

  • Porphyria Variegata, Susceptibility To

  • Protocoproporphyria

  • Porphyria Variegate

  • Porphyria South African Type

  • Pv

  • Porphyria, Variegate

  • Vp - [Variegate Porphyria]
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133677 Mono(2-ethyl-5-hydroxyhexyl) phthalate 99.03% Unkown
HY-170322 TDO2-IN-1 99.44% Unkown
HY-114319 β-Cembrenediol 98.16% Unkown
HY-161996 IDO1-IN-25 Inhibitor / Unkown
HY-184027 IDO1/TDO-IN-12 Inhibitor / Unkown
HY-184028 IDO1-IN-37 Inhibitor / Unkown
HY-184079 TDO2-IN-2 / Unkown
HY-RS14331 TDO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1011921 TDO2-IN-3 / Unkown
HY-RS18976 Tdo2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25465 Tdo2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TDO2 VGNC VGNC:47217
Rattus norvegicus TDO2 RGD RGD:68370
Mus musculus TDO2 MGD MGI:1928486
Bos taurus TDO2 VGNC VGNC:35712
Macaca mulatta TDO2 VGNC VGNC:78298
Felis catus TDO2 VGNC VGNC:66044
Others TDO2 NCBI