NR1D1 - nuclear receptor subfamily 1 group D member 1 Gene

Also Known as EAR1; hRev; THRA1; THRAL; ear-1; REVERBA; REVERBalpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9572

About NR1D1

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:40,092,793-40,100,589 (from NCBI)

This gene has 1 transcript (splice variant), 378 orthologues and 18 paralogues. Ubiquitous expression in ovary (RPKM 21.5), brain (RPKM 21.4) and 24 other tissues.

Summary

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor Aryl Hydrocarbon Receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]

NR1D1 Products (1)

mRNA Protein Name
NM_021724.5 NP_068370.1 nuclear receptor subfamily 1 group D member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8622974 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15761026 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
8622974 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19955433 GOA
enables heme binding IDA
IDA: Inferred from direct assay
18006707 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17892483 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
18511497 GOA
enables transcription corepressor binding IDA
IDA: Inferred from direct assay
15761026 GOA
enables transcription corepressor binding IMP
IMP: Inferred from mutant phenotype
18006707 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
18511497 GOA
NOT involved in cholesterol homeostasis IDA
IDA: Inferred from direct assay
18511497 GOA
involved in intracellular glucose homeostasis IMP
IMP: Inferred from mutant phenotype
18006707 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15761026 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18006707 GOA
involved in negative regulation of toll-like receptor 4 signaling pathway IMP
IMP: Inferred from mutant phenotype
18511497 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19955433 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8622974 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18511497 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
18511497 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR1D1 Protein Structure

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (131 - 200)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (435 - 606)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 614 a.a.
Protein Preferred Names Protein Names

nuclear receptor subfamily 1 group D member 1

  • Rev-ErbAalpha

NR1D1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NR1D1 P20393 APOA4 Homo sapiens P06727
Confocal
24311788
Intra
NR1D1 P20393 APOA4 Homo sapiens P06727
Anti Tag CoIP
24311788
Intra
NR1D1 P20393 APOA4 Homo sapiens P06727
PLA
24311788
Intra
NR1D1 P20393 NCOR1 Homo sapiens O75376
Y2H
20581824
Intra
NR1D1 P20393 NCOR1 Homo sapiens O75376
X-Ray Diffraction
20581824
Intra
NR1D1 P20393 NCOR1 Homo sapiens O75376
FRET
20581824
Intra
NR1D1 P20393 HUWE1 Homo sapiens Q7Z6Z7
Anti Bait CoIP
20534529
Intra
NR1D1 P20393 HUWE1 Homo sapiens Q7Z6Z7
Anti Tag CoIP
20534529
Intra
NR1D1 P20393 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
NR1D1 P20393 TDO2 Homo sapiens P48775
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

NR1D1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81681 NR1D1 Antibody (YA1426) WB, ICC/IF Human, Mouse, Rat
HY-P81681A NR1D1 Antibody (YA1426)(PBS only) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Hypothyroidism, Congenital, Nongoitrous, 6

  • CHNG6

  • Congenital Nongoitrous Hypothyroidism 6

  • Hypothyroidism, Congenital, Non-Goitrous, 6

  • Hypothyroidism, Congenital, Nongoitrous, Type 6
Rem Sleep Behavior Disorder

  • Rapid Eye Movement Sleep Behavior Disorder

  • Rem Sleep Behaviour Disorder

  • Rapid Eye Movement Sleep Behaviour Disorder

  • Rem - [Rapid Eye Movement] Behaviour Disorder
Delayed Sleep Phase Disorder

  • Delayed Sleep Phase Syndrome

  • Delayed Sleep Phase Syndrome, Susceptibility To

  • DSPD

  • Delayed Sleep Phase Disorder, Susceptibility To

  • DSPS

  • Sleep Phase, Delayed, Disorder

  • Sleep Phase Syndrome, Delayed, Susceptibility To
Advanced Sleep Phase Syndrome

  • Fasps

  • Familial Advanced Sleep-Phase Syndrome

  • Advanced Sleep Phase Syndrome, Familial

  • Familial Advanced Sleep Phase Syndrome

  • Sleep Phase Syndrome, Advanced, Familial

  • Advanced Sleep-Phase Syndrome, Familial
Brachydactyly, Type E1

  • Brachydactyly Type E1

  • Brachydactyly Type E

  • BDE1

  • Brachydactyly, Type E

  • Bde

  • Type E Brachydactyly

  • Brachydactyly E1

  • Brachydactyly Syndrome Type E
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Sleep Disorder

  • Sleep Disorders

  • Non-Organic Sleep Disorder
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09527 NR1D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18073 Nr1d1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24548 Nr1d1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NR1D1 VGNC VGNC:32228
Mus musculus NR1D1 MGD MGI:2444210
Rattus norvegicus NR1D1 RGD RGD:628827
Macaca mulatta NR1D1 VGNC VGNC:75502
Canis familiaris NR1D1 VGNC VGNC:43940
Felis catus NR1D1 VGNC VGNC:68542
Others NR1D1 NCBI