IDO1/TDO-IN-12
IDO1/TDO-IN-12 is an IDO1/TDO2 inhibitor with IC50 values of 0.825 and 4.04 μM, respectively. IDO1/TDO-IN-12 interacts with the ferrous heme cofactor in IDO1 as a non-competitive tryptophan inhibitor. IDO1/TDO-IN-12 inhibits nitric oxide production in LPS (HY-D1056)-stimulated immune cells. IDO1/TDO-IN-12 relieves pulmonary edema and lung injury in LPS-induced mouse models. IDO1/TDO-IN-12 can be used for the research of acute lung injury (ALI).
For research use only. We do not sell to patients.
- CAS No.: 2841468-09-3
- Formula: C19H17ClF3N3O5S2
- Molecular Weight:523.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IDO1 0.825 μM (IC50) |
TNF-α |
IL-1β |
IDO1/TDO-IN-12 (compound 22) (48 h) inhibits IDO1 activity in IFN-γ-stimulated BxPC-3 cells with an IC50 of 0.854 μM[1].
IDO1/TDO-IN-12 (0.05-5.0 μM; 48 h) inhibits LPS-induced NO production in RAW264.7 cells in a concentration-dependent manner, with 31.3%, 40.2%, and 78.1% inhibition at 0.05, 0.5, and 5.0 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
response and lung injury in a mouse model of ALI[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice (male, 8 weeks old) with LPS-induced acute lung injury)[1]
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Dosage:15; 50; 100 mg/kg
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Administration:i.p.; two doses; 0.5 h pre-LPS and 12 h post-LPS
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Result:Significantly reduced pulmonary edema (lung wet/dry ratio) compared to LPS-only group, with no dose-dependent reduction observed.
Reduced lung tissue levels of TNF-α and IL-1β in a dose-dependent manner.
Protected against lung injury in a dose-dependent manner based on H&E staining lung injury scoring.
Reduced lung tissue expression of myeloperoxidase (MPO) and citrullinated histone H3 (CitH3) in a dose-dependent manner.
Caused no significant changes in mouse body weight across any treatment groups.
Chemical Information
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CAS No. 2841468-09-3
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Molecular Weight 523.93
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Formula C19H17ClF3N3O5S2
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SMILES
O=C(C1=CC2=C(OC(S(CC3=CC=C(C=C3)Cl)=O)=N2)C=C1)NCCCNS(=O)(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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