2841468-09-3
Chemical Structure
IDO1/TDO-IN-12
- CAS No.: 2841468-09-3
- Formula:C19H17ClF3N3O5S2
- Molecular Weight:523.93
InChIKey: CJRIODMZKXKJCI-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(OC(S(CC3=CC=C(C=C3)Cl)=O)=N2)C=C1)NCCCNS(=O)(C(F)(F)F)=O
Biological Activity: IDO1/TDO-IN-12 is an IDO1/TDO2 inhibitor with IC50 values of 0.825 and 4.04 μM, respectively. IDO1/TDO-IN-12 interacts with the ferrous heme cofactor in IDO1 as a non-competitive tryptophan inhibitor. IDO1/TDO-IN-12 inhibits nitric oxide production in LPS (HY-D1056)-stimulated immune cells. IDO1/TDO-IN-12 relieves pulmonary edema and lung injury in LPS-induced mouse models. IDO1/TDO-IN-12 can be used for the research of acute lung injury (ALI)[1].
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IDO1/TDO-IN-12 | IDO1/TDO-IN-12 is an IDO1/TDO2 inhibitor with IC50 values of 0.825 and 4.04 μM, respectively. IDO1/TDO-IN-12 interacts with the ferrous heme cofactor in IDO1 as a non-competitive tryptophan inhibitor. IDO1/TDO-IN-12 inhibits nitric oxide production in LPS (HY-D1056)-stimulated immune cells. IDO1/TDO-IN-12 relieves pulmonary edema and lung injury in LPS-induced mouse models. IDO1/TDO-IN-12 can be used for the research of acute lung injury (ALI). | |||||||||||||||||||||
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