IDO1

IDO1 Related Products (31):

By Type:	Pan (8) Selective (19)

Cat. No.	Product Name	Effect	Purity

HY-15689

Epacadostat	Inhibitor	99.66%
Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC₅₀ of 71.8 nM.

HY-101560

Linrodostat	Inhibitor	99.89%
Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ value of 1.1 nM in IDO1-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers.

HY-N0110

Palmatine chloride	Inhibitor	99.77%
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.

HY-13983

IDO-IN-7	Inhibitor	99.98%
IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC₅₀ of 38 nM.

HY-101111

PF-06840003	Inhibitor	99.95%
PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC₅₀s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively.

HY-120742

MMG-0358	Inhibitor
MMG-0358 is a potent IDO1 inhibitor. MMG-0358 shows IC₅₀ values of 2 nM in a cellular assay on mIDO1, 80 nM in a cellular assay on hIDO1, 330 nM in an enzymatic assay on hIDO1 at pH 6.5, and 71 nM in an enzymatic assay on hIDO1 at pH 7.4.

HY-161348

AT-0174	Inhibitor
AT-0174 is an orally active dual inhibitor of IDO1/TDO2 (tryptophan 2,3-dioxygenase-2) with IC₅₀ values of 0.17 and 0.25 μM, respectively. AT-0174 has antitumor activity.

HY-148383

DP00477	Inhibitor	99.03%
DP00477 is a potent IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor with an IC₅₀ value of 7.0 µM. DP00477 has the potential for the research of cancer.

HY-151108

IDO1/TDO-IN-4	Inhibitor	99.23%
IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC₅₀ values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π−π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders.

HY-111540

LY-3381916	Inhibitor	99.54%
LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

HY-131911

PROTAC IDO1 Degrader-1	Inhibitor	98.17%
PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC₅₀=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells.

HY-151093

IDO2-IN-1	Inhibitor	98.86%
IDO2-IN-1 is an orally active and potent Indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with an IC₅₀ value of 112 nM. IDO2-IN-1 can be used for inflammatory autoimmunity research.

HY-N0110B

Palmatine hydroxide	Inhibitor	99.64%
Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.

HY-18769

BMS-978587	Inhibitor	99.92%
BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

HY-139204

BMS-986242	Inhibitor	99.42%
BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer.

HY-112147

IDO1 and HDAC1 Inhibitor	Inhibitor
IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC₅₀s of 69.0 nM and 66.5 nM, respectively.

HY-145280

IDO1/2-IN-1	Inhibitor	98.06%
IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC₅₀s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active.

HY-144468

IDO1-IN-17	Inhibitor
IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC₅₀ of 0.44 μM in hela cells.

HY-147772

ZC0101	Inhibitor
ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC₅₀ values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells.

HY-D0033

Roxyl-9	Inhibitor	99.22%
Roxyl-9 is a IDO1 (Indoleamine 2,3-dioxygenase 1) inhibitor.

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