2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO1/2-IN-1

IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active.

For research use only. We do not sell to patients.

IDO1/2-IN-1 Chemical Structure

IDO1/2-IN-1 Chemical Structure

CAS No. : 2310286-45-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 662 In-stock
Solution
10 mM * 1 mL in DMSO USD 662 In-stock
Solid
5 mg USD 620 In-stock
10 mg USD 980 In-stock
25 mg USD 1950 In-stock
50 mg USD 3250 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of IDO1/2-IN-1:

IDO1/2-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

View All Isoforms
IDO1 IDO2 IDO

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Description

IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active[1].

IC50 & Target[1]

IDO1

28 nM (IC50)

IDO2

144 nM (IC50)

Molecular Weight

485.27

Formula

C16H18BrFN8O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC1=CC=C(C=C1Br)/N=C(C2=NON=C2NCCN3N=NC(COCCO)=C3)/NO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0607 mL 10.3035 mL 20.6071 mL
5 mM 0.4121 mL 2.0607 mL 4.1214 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0607 mL 10.3035 mL 20.6071 mL 51.5177 mL
5 mM 0.4121 mL 2.0607 mL 4.1214 mL 10.3035 mL
10 mM 0.2061 mL 1.0304 mL 2.0607 mL 5.1518 mL
15 mM 0.1374 mL 0.6869 mL 1.3738 mL 3.4345 mL
20 mM 0.1030 mL 0.5152 mL 1.0304 mL 2.5759 mL
25 mM 0.0824 mL 0.4121 mL 0.8243 mL 2.0607 mL
30 mM 0.0687 mL 0.3435 mL 0.6869 mL 1.7173 mL
40 mM 0.0515 mL 0.2576 mL 0.5152 mL 1.2879 mL
50 mM 0.0412 mL 0.2061 mL 0.4121 mL 1.0304 mL
60 mM 0.0343 mL 0.1717 mL 0.3435 mL 0.8586 mL
80 mM 0.0258 mL 0.1288 mL 0.2576 mL 0.6440 mL
100 mM 0.0206 mL 0.1030 mL 0.2061 mL 0.5152 mL
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IDO1/2-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1/2-IN-12310286-45-2Indoleamine 2,3-Dioxygenase (IDO)antitumorCT26 xenograft mouse modelsIDO1IDO2oralInhibitorinhibitorinhibit

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