IDO1/2-IN-1
Based on 1 Customer Validation
IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active.
For research use only. We do not sell to patients.
- Purity: 98.06%
- CAS No.: 2310286-45-2
- Formula: C16H18BrFN8O4
- Molecular Weight:485.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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IDO1 28 nM (IC50) |
IDO2 144 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CT26 | IC50 |
61.96 μM
Compound: 4t
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Cytotoxicity against mouse CT26 cells assessed as reduction in cell viability by CCK8 assay
Cytotoxicity against mouse CT26 cells assessed as reduction in cell viability by CCK8 assay
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[PMID: 34854662] |
| HCT-116 | IC50 |
56.13 μM
Compound: 4t
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by CCK8 assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by CCK8 assay
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[PMID: 34854662] |
| HT-29 | IC50 |
8325 μM
Compound: 4t
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Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by CCK8 assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by CCK8 assay
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[PMID: 34854662] |
Chemical Information
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CAS No. 2310286-45-2
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Appearance Solid
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Molecular Weight 485.27
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Formula C16H18BrFN8O4
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Color Off-white to light yellow
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SMILES
FC1=CC=C(C=C1Br)/N=C(C2=NON=C2NCCN3N=NC(COCCO)=C3)/NO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (206.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0607 mL | 10.3035 mL | 20.6071 mL | 51.5177 mL |
| 5 mM | 0.4121 mL | 2.0607 mL | 4.1214 mL | 10.3035 mL | |
| 10 mM | 0.2061 mL | 1.0304 mL | 2.0607 mL | 5.1518 mL | |
| 15 mM | 0.1374 mL | 0.6869 mL | 1.3738 mL | 3.4345 mL | |
| 20 mM | 0.1030 mL | 0.5152 mL | 1.0304 mL | 2.5759 mL | |
| 25 mM | 0.0824 mL | 0.4121 mL | 0.8243 mL | 2.0607 mL | |
| 30 mM | 0.0687 mL | 0.3435 mL | 0.6869 mL | 1.7173 mL | |
| 40 mM | 0.0515 mL | 0.2576 mL | 0.5152 mL | 1.2879 mL | |
| 50 mM | 0.0412 mL | 0.2061 mL | 0.4121 mL | 1.0304 mL | |
| 60 mM | 0.0343 mL | 0.1717 mL | 0.3435 mL | 0.8586 mL | |
| 80 mM | 0.0258 mL | 0.1288 mL | 0.2576 mL | 0.6440 mL | |
| 100 mM | 0.0206 mL | 0.1030 mL | 0.2061 mL | 0.5152 mL |
IDO1/2-IN-1 Related Classifications
HY-145280 Related Classifications
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